In vitro antiplasmodial and cytotoxicity activities of 14 medicinal plants from Kenya

South African Journal of Botany

Volumn 73, Issue 2, 2007, Pages 204-207

  Irungu, Beatrice N ^a   Rukunga, Geoffrey M ^a   Mungai, Geoffrey M ^b   Muthaura, Charles N ^a  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b INSTITUTE OF PRIMATE RESEARCH   (Kenya)

Author keywords

Antiplasmodial; Cytotoxicity; Medicinal plants; Plasmodium

Indexed keywords

ANTIBIOTICS; ANTIMALARIAL AGENT; ANTIMICROBIAL ACTIVITY; MEDICINAL PLANT; METHANOL; PLANT EXTRACT; PROTOZOAN; TOXICITY TEST;

AFRICA; EAST AFRICA; KENYA; SUB-SAHARAN AFRICA;

MAMMALIA; PLASMODIUM FALCIPARUM; TURRAEA; VERNONIA; VERNONIA LASIOPUS;

EID: 33947727979     PISSN: 02546299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sajb.2006.11.004     Document Type: Article

References (17)

1. Ahmed S.A., Gogal R.M., and Walsh J.E. A new rapid and simple non-radioactive assay to monitor and determine proliferation of lymphocytes. An alternative to [3H]thymidine incorporation assay. Journal of Immunology Methods 170 (1994) 211-224
2. Atindehov K.K., Schmid C., Brun R., Kone M.W., and Traore D. Antitrypanosomal and antiplasmodial activities of medicinal plants from Cote D'Ivore. Journal of Ethnopharmacology 90 (2004) 221-227
3. Bentje H. The Kenya Trees, Shrubs and Lianas (1994), National Museums of Kenya
4. Clarkson C., Maharaj V.J., Crouch N.R., Olwen M.G., Pillay P., Matsabisa M.G., Bhagwandin N., Smith P.J., and Folb P.I. In vitro antiplasmodial activity of medicinal plants native to or naturalized in South Africa. Journal of Ethnopharmacology 92 (2004) 177-191
5. Desjardins R.E., Canfield C.J., Haynes J.D., and Chulay J.D. Quantitative assessment of antimalarial activity in vitro by semi automated microdilution technique. Antimicrobial Agents and Chemotherapy 16 (1979) 710-718
6. Kirira P.G., Rukunga G.M., Wanyonyi A.W., Muregi F.M., Gathirwa J.W., Muthaura C.N., Omar S.A., Tolo F., Mungai G.M., and Ndiege I.O. Antiplasmodial activity and toxicity of extracts of plants used in traditional malaria therapy in Meru and Kilifi districts of Kenya. Journal of Ethnopharmacology 106 (2006) 403-407
7. Koch A., Tamez P., Pezzuto J., and Soejarto D. Evaluation of plants used for antimalarial treatment by Maasai of Kenya. Journal of Ethnophamacology 101 (2005) 95-99
8. Kuria K.A., De coster, Muriuki S., Masengo C., Kibwage W., Hoogmartens I., and Laekeman G.M. Antimalarial activity of Ajuga remota Benth (Labiatae) and Caesalpinia volkensii Harms (Caesalpiniaceae). In vitro confirmation of ethnopharmacological use. Journal of Ethnopharamacology 74 (2001) 141-148
9. Maria do Ceu de M., Martins A.P., Gomes M., Paira J., Prorerica da Cunha A., and Virgilio do R. Antimalarial activity of medicinal plants used in traditional medicine in S. Tome and Principle Island. Journal of Ethnopharmacology 81 (2002) 23-29
10. Muregi F.W., Chhabra S.C., Njagi E.N.W., Lang'at-Thoruwa C., Njue W.M., Orago A.S.S., Omar S., and Ndiege I.O. In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects. Journal of Ethnopharmacology 84 (2003) 235-239
11. Page C., Page M., and Noel C. A new flourimetric assay for cytotoxicity measurements in vitro. International Journal of Oncology 3 (1993) 473-476
12. Ridley R.G. Medical need, scientific opportunity and the drive for antimalarial drugs. Nature 415 (2002) 686-693
13. Tagbota S., and Townson S. Antiparasitic properties of medicinal plants and other naturally occurring products. Advanced Parasitology 50 (2001) 199-295
14. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
15. WHO. Traditional medicine Fact sheet No. 134 (2003)
16. Willox M.L., and Bodeker G. Traditional herbal medicines for malaria. British Medical Journal 329 (2004) 1156-1159
17. Zirihi G.N., Mambu L., Guede-Guina F., Bodo B., and Grellier P. In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology 98 (2005) 281-285