Cloning, characterization and mapping of porcine CD14 reveals a high conservation of mammalian CD14 structure, expression and locus organization

Developmental and Comparative Immunology

Volumn 31, Issue 7, 2007, Pages 729-737

  Petersen, Cathrine Bie ^a   Nygård, Ann Britt ^a   Fredholm, Merete ^a   Aasted, Bent ^a   Salomonsen, Jan ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

CD14; Innate immunity; LPS receptor; Porcine

Indexed keywords

AMINO ACID; CD14 ANTIGEN; CYTOKINE; LIPOPOLYSACCHARIDE; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CHROMOSOME 2; CHROMOSOME 5Q; CYTOKINE RELEASE; GENE LOCUS; GENE MAPPING; GENETIC CONSERVATION; GENETIC ORGANIZATION; GENETIC TRANSCRIPTION; INNATE IMMUNITY; MEDIATOR RELEASE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SWINE; SYNTENY;

MAMMALIA; SUS;

EID: 33947721512     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2006.05.016     Document Type: Article

References (49)

1. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., and Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 (1990) 1431-1433
2. Medzhitov R., and Janeway Jr. C. Innate immune recognition: mechanisms and pathways. Immunol Rev 173 (2000) 89-97
3. Bazil V., Baudys M., Hilgert I., Stefanova I., Low M.G., Zbrozek J., et al. Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14. Mol Immunol 26 7 (1989) 657-662
4. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
5. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189 11 (1999) 1777-1782
6. Zhang F.X., Kirschning C.J., Mancinelli R., Xu X.P., Jin Y., Faure E., et al. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 274 12 (1999) 7611-7614
7. Fujihara M., Muroi M., Tanamoto K., Suzuki T., Azuma H., and Ikeda H. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther 100 (2003) 171-194
8. Kaisho T., Takeuchi O., Kawai T., Hoshino K., and Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol 166 (2001) 5688-5694
9. Cohen J. The immunopathogenesis of sepsis. Nature 420 (2002) 885-891
10. Haziot A., Ferrero E., Kontgen F., Hijiya N., Yamamoto S., Silver J., et al. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity 4 (1996) 407-414
11. Frey E.A., Miller D.S., Jahr T.G., Sundan A., Bazil V., Espevik T., et al. Soluble CD14 participates in the response of cells to lipopolysaccharide. J Exp Med 176 (1992) 1665-1671
12. Kitchens R.L., Thompson P.A., Viriyakosol S., O'Keefe G.E., and Munford R.S. Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins. J Clin Invest 108 (2001) 485-493
13. Bas S., Gauthier B.R., Spenato U., Stingelin S., and Gabay C. CD14 is an acute-phase protein. J Immunol 172 (2004) 4470-4479
14. Schwandner R., Dziarski R., Wesche H., Rothe M., and Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 274 (1999) 17406-17409
15. Jiang Z., Georgel P., Du X., Shamel L., Sovath S., Mudd S., et al. CD14 is required for MyD88-independent LPS signaling. Nat Immunol 6 6 (2005) 565-570
16. Devitt A., Moffatt O.D., Raykundalia C., Capra J.D., Simmons D.L., and Gregory C.D. Human CD14 mediates recognition and phagocytosis of apoptotic cells. Nature 392 (1998) 505-509
17. Alvarez B., Revilla C., Chamorro S., Lopez-Fraga M., Alonso F., Dominguez J., et al. Molecular cloning, characterization and tissue expression of porcine toll-like receptor 4. Dev Comp Immunol 30 (2006) 345-355
18. Shi X.W., and Tuggle C.K. Rapid communication: genetic linkage and physical mapping of the porcine lipopolysaccharide-binding protein (LBP) gene. J Anim Sci 79 (2001) 556-557
19. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16 3 (1988) 1215
20. Hawken R.J., Murtaugh J., Flickinger G.H., Yerle M., Robic A., Milan D., et al. A first-generation porcine whole-genome radiation hybrid map. Mamm Genome 10 (1999) 824-830
21. Milan D., Hawken R., Cabau C., Leroux S., Genet C., Lahbib Y., et al. IMpRH server: an RH mapping server available on the Web. Bioinformatics 16 6 (2000) 558-559
22. Tregaskes C.A., and Young J.R. Immunology methods manual. Chapter 32.12: cloning of chicken lymphocyte marker cDNAs from eukaryotic expression libraries. In: Lefkovits I. (Ed). Immunological methods manual (1996), Academic Press Ltd, New York 2295-2314
23. Koskinen R., Gobel T.W., Tregaskes C.A., Young J.R., and Vainio O. The structure of avian CD5 implies a conserved function. J Immunol 160 (1998) 4943-4950
24. Ferrero E., Hsieh C.L., Francke U., and Goyert S.M. CD14 is a member of the family of leucine-rich proteins and is encoded by a gene synthetic with multiple receptor genes. J Immunol 145 (1990) 331-336
25. Matsuura K., Setoguchi M., Nasu N., Higuchi Y., Yoshida S., Akizuki S., et al. Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res 17 5 (1989) 2132
26. Ikeda A., Takata M., Taniguchi T., and Sekikawa K. Molecular cloning of bovine CD14 gene. J Vet Med Sci 59 8 (1997) 715-719
27. Athanasou N.A., Alvarez J.I., Ross F.P., Quinn J.M., and Teitelbaum S.L. Species differences in the immunophenotype of osteoclasts and mononuclear phagocytes. Calcif Tissue Int 50 (1992) 427-432
28. Eisenhaber B., Bork P., and Eisenhaber F. Sequence properties of GPI-anchored proteins near the omega-site: constraints for the polypeptide binding site of the putative transamidase. Protein Eng 11 2 (1998) 1155-1161
29. Kajava A.V., Vassart G., and Wodak S.J. Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats. Structure 3 (1995) 867-877
30. Kim J.I., Lee C.J., Jin M.S., Lee C.H., Paik S.G., Lee H., et al. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem 280 12 (2005) 11347-11351
31. Viriyakosol S., and Kirkland T.N. A region of human CD14 required for lipopolysaccharide binding. J Biol Chem 270 1 (1995) 361-368
32. Stelter F., Bernheiden M., Menzel R., Jack R.S., Witt S., Fan X., et al. Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli. Eur J Biochem 243 (1997) 100-109
33. Muroi M., Ohnishi T., and Tanamoto K. Regions of the mouse CD14 molecule required for toll-like receptor 2- and 4-mediated activation of NF-kappa B. J Biol Chem 277 44 (2002) 42372-42379
34. McGinley M.D., Narhi L.O., Kelley M.J., Davy E., Robinson J., Rohde M.F., et al. CD14: physical properties and identification of an exposed site that is protected by lipopolysaccharide. J Biol Chem 270 10 (1995) 5213-5218
35. Juan T.S., Hailman E., Kelley M.J., Busse L.A., Davy E., Empig C.J., et al. Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64. J Biol Chem 270 10 (1995) 5219-5224
36. Juan T.S., Hailman E., Kelley M.J., Wright S.D., and Lichenstein H.S. Identification of a domain in soluble CD14 essential for lipopolysaccharide (LPS) signaling but not LPS binding. J Biol Chem 270 29 (1995) 17237-17242
37. Juan T.S., Kelley M.J., Johnson D.A., Busse L.A., Hailman E., Wright S.D., et al. Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS. J Biol Chem 270 3 (1995) 1382-1387
38. Stelter F., Loppnow H., Menzel R., Grunwald U., Bernheiden M., Jack R.S., et al. Differential impact of substitution of amino acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide. J Immunol 163 (1999) 6035-6044
39. Viriyakosol S., Mathison J.C., Tobias P.S., and Kirkland T.N. Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide. J Biol Chem 275 5 (2000) 3144-3149
40. Iwaki D., Nishitani C., Mitsuzawa H., Hyakushima N., Sano H., and Kuroki Y. The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular toll-like receptor 2 domain. Biochem Biophys Res Commun 328 (2005) 173-176
41. Cepica S., Prochazka R., Civanova K., Knoll A., Nemcova L., Masopust M., et al. Partial molecular characterization and mapping of the GDF9 gene to porcine chromosome 2. Anim Genet 35 (2004) 261-262
42. Buitkamp J., Schwaiger F.W., Solinas-Toldo S., Fries R., and Epplen J.T. The bovine interleukin-4 gene: genomic organization, localization, and evolution. Mamm Genome 6 (1995) 350-356
43. Musilova P., Kubickova S., Vychodilova-Krenkova L., Kralik P., Matiasovic J., Hubertova D., et al. Cytogenetic mapping of immunity-related genes in the domestic horse. Anim Genet 36 (2005) 507-510
44. Nishimura M., and Naito S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull 28 5 (2005) 886-892
45. Fearns C., Kravchenko V.V., Ulevitch R.J., and Loskutoff D.J. Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med 181 (1995) 857-866
46. Su G.L., Dorko K., Strom S.C., Nussler A.K., and Wang S.C. CD14 expression and production by human hepatocytes. J Hepatol 31 (1999) 435-442
47. Haverson K., Bailey M., Higgins V.R., Bland P.W., and Stokes C.R. Characterization of monoclonal antibodies specific for monocytes, macrophages and granulocytes from porcine peripheral blood and mucosal tissues. J Immunol Methods 170 (1994) 233-245
48. Setoguchi M., Nasu N., Yoshida S., Higuchi Y., Akizuki S., and Yamamoto S. Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. Biochim Biophys Acta 1008 (1989) 213-222
49. Takai N., Kataoka M., Higuchi Y., Matsuura K., and Yamamoto S. Primary structure of rat CD14 and characteristics of rat CD14, cytokine, and NO synthase mRNA expression in mononuclear phagocyte system cells in response to LPS. J Leukocyte Biol 61 (1997) 736-744