Environmentally benign N-Boc protection under solvent- and catalyst-free conditions

Synlett

Volumn , Issue 5, 2007, Pages 806-808

  Jia, Xueshun ^a   Huang, Qing ^a   Li, Jian ^a   Li, Shaoyu ^a   Yang, Qiushi ^a  

^a SHANGHAI UNIVERSITY   (China)

Author keywords

Catalyst free; Environmentally benign; N Boc protection; Solvent free

Indexed keywords

AMINE; CARBONYL DERIVATIVE; SOLVENT; TERT BUTOXYCARBONYL; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; ELECTRON; STEREOCHEMISTRY;

EID: 33947712193     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-970755     Document Type: Article

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27. 2O (1 mmol) that was being magnetically stirred in oven-dried glassware at r.t. was added the amine (1 mmol). Rapid heat evolution and bubbling was then observed. The mixture was stirred until completion of the reaction. The product was purified using silica gel column chromatography eluting with hexane-EtOAc (5:1) to afford the corresponding N-Boc protected product. All of the products are known and were characterized by comparison of their spectral data with those of authentic samples.
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