Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations

International Journal of Pharmaceutics

Volumn 335, Issue 1-2, 2007, Pages 12-19

  Sakata, Yukoh ^a   Tanabe, Eishi ^b   Sumikawa, Toshiharu ^a   Shiraishi, Sumihiro ^a   Tokudome, Yoshihiro ^c   Otsuka, Makoto ^c  

^a WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

^b Western Hiroshima Prefecture Industrial Research Institute   (Japan)

^c Department of Pharmaceutical Technology   (Japan)

Author keywords

Cloperastine hydrochloride; Eutectic mixture; Interaction; Paracetamol; Vertical granulation

Indexed keywords

CLOPERASTINE; CLOPERASTINE PLUS PARACETAMOL; PARACETAMOL; PARACETAMOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SYNTHESIS; HARDNESS; PRIORITY JOURNAL; TABLET FORMULATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANTITUSSIVE AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG COMBINATIONS; DRUG STABILITY; HARDNESS; HYDROGEN BONDING; MICROSCOPY, ELECTRON, SCANNING; PHASE TRANSITION; PIPERIDINES; POWDERS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS;

EID: 33947694780     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.10.038     Document Type: Article

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