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33947633734
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note
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The use of 4Å MS was found to be advantageous in the rainy season. Otherwise a 10-20% drop in product yield was observed, though no decline in enantioselectivity was observed.
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38
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0033576992
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40
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33947696421
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note
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The use of the corresponding tert-butyl ester required 7 h for completion of the reaction to give tert-butyl 3-phenylindan-1-one-2-carboxyl ate in 88% yield, which, upon removal of the ester group, produced (R)-la in 90% yield with 30% ee.
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33947704932
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45
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33947661143
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note
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The preferred absolute stereochemistry of 1b was assigned by analogy.
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