Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses

Acta Haematologica

Volumn 117, Issue 3, 2007, Pages 149-155

  Albisetti, Manuela ^a   Moeller, Alexander ^a   Waldvogel, Katharina ^a   Bernet Buettiker, Vera ^a   Cannizzaro, Vincenzo ^a   Anagnostopoulos, Alexia ^a   Balmer, Christian ^a   Schmugge, Markus ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Artery; Children; Deep vein thrombosis; Thrombophilia; Thrombosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTITHROMBIN; BLOOD CLOTTING FACTOR 5; LIPOPROTEIN A; PROTEIN C; PROTEIN S;

ADOLESCENT; ANTITHROMBIN DEFICIENCY; ARTERY THROMBOSIS; ARTICLE; BLOOD CLOTTING FACTOR 5 DEFICIENCY; CATHETER; CHILD; CLINICAL ARTICLE; GENE MUTATION; HOMOZYGOSITY; HUMAN; INFANT; PREVALENCE; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RISK FACTOR; VEIN THROMBOSIS;

ADOLESCENT; ARTERIES; BLOOD COAGULATION DISORDERS, INHERITED; CHILD; CHILD, PRESCHOOL; FACTOR V; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LIPOPROTEIN(A); MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POINT MUTATION; PREVALENCE; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; PROTHROMBIN; RISK FACTORS; THROMBOPHILIA; VEINS; VENOUS THROMBOSIS;

EID: 33947686718     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000097462     Document Type: Article

References (38)

1. Andrew M, David M, Adams M, Ali K, Anderson R, Barnard D, Berstein M, Brisson L, Cairney B, DeSai D, Grant R, Israels S, Jardine L, Luke B, Massicotte P, Silva M: Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood 1994;83:1251-1257.
2. Albisetti M, Schmugge M, Haas R, Eckhardt BP, Bauersfeld U, Baenziger O, Hug MI: Arterial thromboembolic complications in critically ill children. J Crit Care 2005;20:296-300.
3. Massicotte MP, Dix D, Monagle P, Adams M, Andrew M: Central venous catheter related thrombosis in children: analysis of the Canadian Registry of Venous Thromboembolic Complications. J Pediatr 1998;133:770-776.
4. Price V, Massicotte MP: Arterial thromboembolism in the pediatric population. Semin Thromb Hemost 2003;29:557-565.
5. Martinelli I: Risk factors in venous thromboembolism. Thromb Haemost 2001;86:395-403.
6. Bauer KA, Rosendaal FR, Heit JA: Hypercoagulability: too many tests, too much conflicting data. Hematology Am Soc Hematol Educ Program 2002, pp 353-368.
7. Nowak-Gottl U, von Kries R, Gobel U: Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed 1997;76:F163-F167.
8. Schmidt B, Andrew M: Neonatal thrombosis: report of a prospective Canadian and International Registry. Pediatrics 1995;96:939-943.
9. van Ommen CH, Heijboer H, Büller HR, Hirasing RA, Heijmans HSA, Peters M: Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr 2001;139:676-681.
10. Nowak-Göttl U, Dübbers A, Kececioglu D, Koch HG, Kotthoff S, Runde J, Vielhaber H: Factor V Leiden, protein C, and lipoprotein (a) in catheter-related thrombosis in childhood: a prospective study. J Pediatr 1997;131:608-612.
11. Manco-Johnson M, Sifontes M, Nuss R, Hunger S, Loutzenhiser J, Jacobson L, Drose J, Manco-Johnson M: Coagulation abnormalities in neonatal catheter-related thrombosis (abstract). Thromb Haemost 1999;82(suppl):384.
12. Salonvaara M, Riikonen P, Kekomaki R, Heinonen K: Clinically symptomatic central venous catheter-related deep venous thrombosis in newborns. Acta Paediatr 1999;88:642-646.
13. Knöfler R, Siegert E, Lauterbach I, Taut-Sack H, Siegert G, Gehrisch S, Müller D, Rupprecht E, Kabus M: Clinical importance of prothrombotic risk factors in pediatric patients with malignacy - impact of central venous lines. Eur J Pediatr 1999;158(suppl 3):S147-S150.
14. Hagstrom N, Colangelo S, Knight S, Knag K, Tsongalis G: Inherited prothrombotic risk factors and central venous catheter complications in children with cancer (abstract). Blood 2001;98:90b.
15. Chalmers EA: Heritable thrombophilia and childhood thrombosis. Blood Rev 2001;15:181-189.
16. Monagle P, Michelson AD, Bovill E, Andrew M: Antithrombotic therapy in children. Chest 2001;119:344S-370S.
17. Bernard PS, Lay MJ, Wittwer CT: Integrated amplification and detection of the C677T point mutation in the methylenetetrahydrofolate reductase gene by fluorescence resonance energy transfer and probe melting curves. Anal Biochem 1998;255:101-107.
18. Araki A, Sako Y: Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43-52.
19. Andrew M, Paes B, Johnston M: Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 1990;12:95-104.
20. Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L: Maturation of the hemostatic system during childhood. Blood 1992; 80:1998-2005.
21. Nowak-Göttl U, Junker R, Hartmeier M, Koch HG, Munchow N, Assmann G, von Eckardstein A: Increased lipoprotein (a) is an important risk factor for venous thromboembolism in childhood. Circulation 1999;100:743-748.
22. Revel-Vilk S, Chan AK, Bauman M, Massicotte P: Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. J Thromb Haemost 2003;1:915-921.
23. Bonduel M, Hepner M, Sciuccati G, Pieroni G, Pieroni G, Feliú-Torres A, Mardaraz C, Frontroth JP: Factor V Leiden and prothrombin gene G20210A mutation in children with venous thromboembolism. Thromb Haemost 2002;87:972-977.
24. Korte W, Greiner J, Feldges A, Riesen WF: Increased lipoprotein (a) levels are not a steady prothrombotic defect. Blood 2001;98:1993-1994.
25. Lawson SE, Butler D, Enayat MS, Williams MD: Congenital thrombophilia and thrombosis: a study in a single centre. Arch Dis Child 1999;81:176-178.
26. Ehrenforth S, Junker R, Koch HG, Kreuz W, Münchow N, Scharrer I, Nowak-Göttl U: Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Eur J Pediatr 1999;158(suppl 3):S97-S104.
27. Schobess R, Junker R, Auberger K, Münchow N, Burdach S, Nowak-Göttl U: Factor V G1691A and prothrombin G20210A in childhood spontaneous venous thrombosis - evidence of an age-dependent thrombotic onset in carriers of factor V G1691A and prothrombin G20210A mutation. Eur J Pediatr 1999;158(suppl 3):S105-108.
28. Aschka I, Aumann V, Bergmann F, Budde U, Eberl W, Eckhof-Donovan S, Krey S, Nowak-Göttl U, Schobess R, Sutor AH, Wendisch J, Schneppenheim R: Prevalence of factor V Leiden in children with thrombo-embolism. Eur J Pediatr 1996;155:1009-1014.
29. Herrmann W: The importance of hyperhomocysteinemia as a risk factor for diseases: an overview. Clin Chem Lab Med 2001;39:666-674.
30. Cattaneo M: Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost 1999;81:165-176.
31. Mainou Cid C, Garcia Giralt N, Vilaseca Busca MA, Ferrer Codina I, Meco Lopez JF, Mainou Pinto A, Pinto Sala X, Grinberg Vaisman D, Balcells Comas S: Hyperhomocysteinemia and 677C T methylenetetrahydrofolate reductase polymorphism as a cardiovascular risk factor in childhood. An Esp Pediatr 2002;56:402-408.
32. Koch HG, Nabel P, Junker R, Auberger K, Schobess R, Homberger A, Linnebank M, Nowak-Göttl U: The 677T genotype of the common MTHFR thermolabile variant and fasting homocysteine in childhood venous thrombosis. Eur J Pediatr 1999;158(suppl):S113-S116.
33. Balasa VV, Gruppo RA, Glueck CJ, Stroop D, Becker A, Pillow A, Wang P: The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocystein, prothrombin, and PAI-1 in children and adults. Thromb Haemost 1999;81:739-744.
34. Alessio AC, Annichino-Bizzacchi JM, Bydlowski SP, Eberlin MN, Vellasco AP, Fenalti Höehr N: Polymorphism in the methylenetrahydrofolate reductase and methionine synthase reductase genes and homocystein levels in Brazilian children. Am J Med Genet 2004;128A:256-260.
35. Rees DC, Cox M, Clegg JB: World distribution of factor V Leiden. Lancet 1995;346:1133-1134.
36. Rosendaal FR, Doggen CJ, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH: Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998;79:706-708.
37. Reiner AP, Siscovick DS, Rosendaal FR: Hemostatic risk factors and arterial thrombotic disease. Thromb Haemost 2001;85:584-595.
38. Münchow N, Kosch A, Schobess R, Junker R, Auberger K, Nowak-Göttl U: Role of genetic prothrombotic risk factors in childhood caval vein thrombosis. Eur J Pediatr 1999;158(suppl 3):S109-S112.