A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes

Journal of Biomechanics

Volumn 40, Issue 6, 2007, Pages 1405-1409

  Michalek, Arthur J ^a   Iatridis, James C ^a  

^a University of Vermont   (United States)

Author keywords

Chondrocyte; Intervertebral disc cell; Mechanotransduction; Pericellular matrix; Strain

Indexed keywords

BIOSYNTHESIS; BONE; CELLS; ELASTIC CONSTANTS; FINITE ELEMENT METHOD; MATHEMATICAL MODELS; NUMERICAL METHODS;

CHONDROCYTES; INTERVERTEBRAL DISC CELL; MECHANOTRANSDUCTION; PERICELLULAR MATRIX;

BIOMECHANICS;

ARTICLE; BIOMECHANICS; CARTILAGE CELL; CARTILAGE MATRIX; CELL STRAIN; CELL STRUCTURE; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; MICROENVIRONMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STUDY; SENSITIVITY ANALYSIS; YOUNG MODULUS;

ANIMALS; BIOMECHANICS; CELLS, CULTURED; CHONDROCYTES; CHONDROGENESIS; COMPUTER SIMULATION; ELASTICITY; EXTRACELLULAR MATRIX; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; STRESS, MECHANICAL;

EID: 33947675353     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2006.05.025     Document Type: Article

References (15)

1. Alexopoulos L.G., Setton L.A., and Guilak F. The biomechanical role of chondrocyte pericellular matrix in normal and osteoarthritic human cartilage. Acta Biomaterialia 1 (2005) 317-325
2. Alexopoulos L.G., Haider M.A., Vail T.P., and Guilak F. Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. Journal of Biomechanical Engineering 125 3 (2003) 323-333
3. Baer A.E., Laursen T.A., Guilak F., and Setton L.A. The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. Journal of Biomechanical Engineering 125 1 (2003) 1-11
4. Bruehlmann S.B., Matyas J.R., and Duncan N.A. Issls prize winner: collagen fibril sliding governs cell mechanics in the anulus fibrosus: an in situ confocal microscopy study of bovine discs. Spine 29 23 (2004) 2612-2620
5. Freeman P.M., Natarajan R.N., Kimura J.H., and Andriacchi T.P. Chondrocyte cells respond mechanically to compressive loads. Journal of Orthopaedic Research 12 3 (1994) 311-320
6. Guilak F., Jones W.R., Ting-Beall H.P., and Lee G.M. The deformation behavior and mechanical properties of chondrocytes in articular cartilage. Osteoarthritis Cartilage 7 1 (1999) 59-70
7. Huang C.Y., Stankiewicz A., Ateshian G.A., and Mow V.C. Anisotropy, inhomogeneity, and tension-compression nonlinearity of human glenohumeral cartilage in finite deformation. Journal of Biomechanics 38 4 (2005) 799-809
8. Hunter C.J., Matyas J.R., and Duncan N.A. Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison. Journal of Anatomy 205 5 (2004) 357-362
9. Jones W.R., Ting-Beall H.P., Lee G.M., Kelley S.S., Hochmuth R.M., and Guilak F. Alterations in the young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. Journal of Biomechanics 32 2 (1999) 119-127
10. Kelly T.A., Wang C.C., Mauck R.L., Ateshian G.A., and Hung C.T. Role of cell-associated matrix in the development of free-swelling and dynamically loaded chondrocyte-seeded agarose gels. Biorheology 41 3-4 (2004) 223-237
11. Knight M.M., Ross J.M., Sherwin A.F., Lee D.A., Bader D.L., and Poole C.A. Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochimica et Biophysica Acta 1526 2 (2001) 141-146
12. Knight M.M., van de Breevaart Bravenboer J., Lee D.A., van Osch G.J., Weinans H., and Bader D.L. Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus. Biochimica et Biophysica Acta 1570 1 (2002) 1-8
13. Nettles D.L., Richardson W.J., and Setton L.A. Integrin expression in cells of the intervertebral disc. Journal of Anatomy 204 6 (2004) 515-520
14. Poole C.A. Articular cartilage chondrons: form, function and failure. Journal of Anatomy 191 1 (1997) 1-13
15. Sheih A., and Athanasiou K.A. Principles of cell mechanics for cartilage tissue engineering. Annals of Biomedical Engineering 31 (2003) 1-11