Reduced production of RNA transcripts from individual DNA plasmids given in a multivalent DNA vaccine formula

Human Vaccines

Volumn 3, Issue 2, 2007, Pages 48-53

  Bacon, David J ^a,b   Sedegah, Martha ^a  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b California   (Peru)

Author keywords

Abrogation; DNA vaccine; Malaria; mRNA; Promoter; Surface proteins

Indexed keywords

DNA VACCINE; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PLASMODIUM FALCIPARUM C SURFACE PROTEIN; PLASMODIUM FALCIPARUM S SURFACE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LYSATE; GENE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MELANOMA CELL; NONHUMAN; PFCSP GENE; PFSSP2 GENE; PLASMID; PLASMODIUM FALCIPARUM; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; RNA TRANSCRIPTION; RNA TRANSLATION; WESTERN BLOTTING;

EID: 33947661390     PISSN: 15548600     EISSN: 15548619     Source Type: Journal    
DOI: 10.4161/hv.3.2.3833     Document Type: Article

References (25)

1. Chen L, Shao HJ, SuYB. Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. Int Immunopharmacol 2004; 4:403-9.
2. Karin N. Induction of protective therapy for autoimmune diseases by targeted DNA vaccines encoding pro-inflammatory cytokines and chemokines. Curr Opin Mol Ther 2004; 6:27-33.
3. Sedegah M, Charoenvit Y, Minh L, Belmonte M, Majam VF, Abot S, Ganeshan H, Kumar S, Bacon DJ, Stowers A, Narum DL, Carucci DJ, Rogers WO. Reduced immunogenicity of DNA vaccine plasmids in mixtures. Gene Ther 2004; 11:448-56.
4. Rotondaro L, Mele A, Rovera G. Efficiency of different viral promoters in directing gene expression in mammalian cells: Effect of 3′-untranslated sequences. Gene 1996; 168:195-8.
5. Yew NS, Wysokenski DM, Wang KX, Ziegler RJ, Marshall J, McNeilly D, Cherry M, Osburn W, Cheng SH. Optimization of plasmid vectors for high-level expression in lung epithelial cells. Hum Gene Ther 1997; 8:575-84.
6. Derrick SC, Repique C, Snoy P, Yang AL, Morris S. Immunization with a DNA vaccine cocktail protects mice lacking CD4 cells against an aerogenic infection with Mycobacterium tuberculosis. Infect Immun 2004; 72:1685-92.
7. Konopka K, Lee NS, Rossi J, Duzgunes N. Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication. Gene 2000; 255:235-44.
8. Sasaki S, Takeshita F, Oikawa T, Kojima Y, Xin KQ, Okuda K, Ishii N. Improvement of DNA vaccine immunogenicity by a dual antigen expression system. Biochem Biophys Res Commun 2004; 315:38-43.
9. Parker SE, Monteith D, Horton H, Hof R, Hernandez P, Vilalta A, Hartikka J, Hobart P, Bentley CE, Chang A, Hedstrom R, Rogers WO, Kumar S, Hoffman SL, Norman JA. Safety of a GM-CSF adjuvant-plasmid DNA malaria vaccine. Gene Ther 2001; 8:1011-23.
10. Price BM, Galloway DR, Baker NR, Gilleland LB, Staczek J, Gilleland Jr HE. Protection against Pseudomonas aeruginosa chronic lung infection in mice by genetic immunization against outer membrane protein F (OprF) of P. aeruginosa. Infect Immun 2001; 69:3510-5.
11. Mellouk S, Berbiguier N, Druilhe P, Sedegah M, Galey B, Yuan L, Leef M, Charoenvit Y, Paul C, Hoffman S, et al. Evaluation of an in vitro assay aimed at measuring protective antibodies against sporozoites. Bull World Health Organ 1990; 68:52-9.
12. Gardner MJ, Tettelin H, Carucci DJ, Cummings LM, Smith HO, Fraser CM, Venter JC, Hoffman SL. The malaria genome sequencing project: Complete sequence of Plasmodium falciparum chromosome 2. Parassitologia 1999; 41:69-75.
13. Chen RW, Piiparinen H, Seppanen M, Koskela P, Sarna S, Lappalainen M. Real-time PCR for detection and quantitation of hepatitis B virus DNA. J Med Virol 2001; 65:250-6.
14. Gardner MJ, Doolan DL, Hedstrom RC, Wang R, Sedegah M, Gramzinski RA, Aguiar JC, Wang H, Margalith M, Hobart P, Hoffman SL. DNA vaccines against malaria: Immunogenicity and protection in a rodent model. J Pharm Sci 1996; 85:1294-300.
15. Kim JJ, Yang J, Manson KH, Weiner DB. Modulation of antigen-specific cellular immune responses to DNA vaccination in rhesus macaques through the use of IL-2, IFN-gamma, or IL-4 gene adjuvants. Vaccine 2001; 19:2496-505.
16. Haga T, Kumabe S, Ikejiri A, Shimizu Y, Li H, Goto Y, Matsui H, Miyata H, Miura T. In vitro and in vivo stability of plasmids in attenuated Salmonella enterica serovar typhimurium used as a carrier of DNA vaccine is associated with its replication origin. Exp Anim 2006; 55:405-9.
17. Doolan DL, Hoffman SL. The complexity of protective immunity against liver-stage malaria. J Immunol 2000; 165:1453-62.
18. Matis C, Chomez P, Picard J, Rezsohazy R. Differential and opposed transcriptional effects of protein fusions containing the VP16 activation domain. FEBS Lett 2001; 499(:92-6.
19. Raadsma H, O'Meara TJ, Egerton JR, Lehrbach PR, Schwartzkoff CL. Protective antibody titers and antigenic competition in multivalent Dichelobacter nodosus fimbrial vaccines using characterised rDNA antigens. Vet Immunol Immunopathol 1994; 40:253-74.
20. Rodriguez F, Harkins S, Slifka MK, Whitton JL. Immunodominance in virus-induced CD8+ T-cell responses is dramatically modified by DNA immunization and is regulated by gamma Interferon. J Virol 2002; 76:4251-9.
21. Dean DA, Dean BS, Muller S, Smith LC. Sequence requirements for plasmid nuclear import. Exp Cell Res 1999; 253:713-22.
22. Heintz NH. Transcription factors and the control of DNA replication. Curr Opin Cell Biol 1992; 4:459-67.
23. Chen PH, Tseng WB, Chu Y, Hsu MT. Interference of the simian virus 40 origin of replication by the cytomegalovirus immediate early gene enhancer: Evidence for competition of active regulatory chromatin conformation in a single domain. Mol Cell Biol 2000; 20:4062-74.
24. Norman JA, Hobart P, Manthorpe M, Felgner P, Wheeler C. Development of improved vectors for DNA-based immunization and other gene therapy applications. Vaccine 1997; 15:801-3.
25. Adam GIR, Miller SJ, Ulleras E, Franklin GC. Cell-type-specific modulation of PDGF-B regulatory elements via viral enhancer competition: A caveat for the use of reference plasmids in transient transfection assays. Gene 1996; 178:25-9.