Male serum Chlamydia trachomatis IgA and IgG, but not heat shock protein 60 IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple

International Journal of Andrology

Volumn 30, Issue 2, 2007, Pages 99-107

  Idahl, A ^a,b   Abramsson, L ^b   Kumlin, U ^b   Liljeqvist, J A ^c   Olofsson, J I ^d  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d Fertility Center Scandinavia   (Sweden)

Author keywords

Chlamydia trachomatis; Infertility; Pregnancy rate; Semen characteristics; Serology; Spermatozoa; Tubal factor

Indexed keywords

BACTERIUM ANTIBODY; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ANTIBODY DETECTION; ARTICLE; CELL DEATH; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FEMALE INFERTILITY; FERTILITY; HUMAN; HUMAN CELL; INFERTILITY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PREGNANCY OUTCOME; PREGNANCY RATE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SEMEN ANALYSIS; SERUM; SEX DIFFERENCE; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TERATOZOOSPERMIA;

ADULT; ANTIBODIES, BACTERIAL; CHAPERONINS; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; FEMALE; FERTILITY; FOLLOW-UP STUDIES; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFERTILITY, MALE; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREGNANCY; PREGNANCY RATE; RETROSPECTIVE STUDIES; SEMEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA;

EID: 33947632946     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2006.00718.x     Document Type: Article

References (44)

1. Ankum, W. M., Mol, B. W., Van der Veen, F. & Bossuyt, P. M. (1996) Risk factors for ectopic pregnancy: a meta-analysis. Fertility and Sterility 65, 1093-1099.
2. Ault, K. A., Statland, B. D., King, M. M., Dozier, D. I., Joachims, M. L. & Gunter, J. (1998) Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility. Infectious Diseases in Obstetrics and Gynecology 6, 163-167.
3. Bjercke, S. & Purvis, K. (1992) Chlamydial serology in the investigation of infertility. Human Reproduction 7, 621-624.
4. Claman, P., Honey, L., Peeling, R. W., Jessamine, P. & Toye, B. (1997) The presence of serum antibody to the chlamydial heat shock protein (CHSP60) as a diagnostic test for tubal factor infertility. Fertility and Sterility 67, 501-504.
5. Dadamessi, I., Eb, F. & Betsou, F. (2005) Combined detection of Chlamydia trachomatis-specific antibodies against the 10 and 60-kDa heat shock proteins as a diagnostic tool for tubal factor infertility: results from a case-control study in Cameroon. FEMS Immunology and Medical Microbiology 45, 31-35.
6. Devroey, P. & Van Steirteghem, A. (2004) A review of ten years experience of ICSI. Human Reproduction Update 10, 19-28.
7. Dieterle, S. & Wollenhaupt, J. (1996) Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. Human Reproduction 11, 1352-1356.
8. Dieterle, S., Mahony, J. B., Luinstra, K. E. & Stibbe, W. (1995) Chlamydial immunoglobulin IgG and IgA antibodies in serum and semen are not associated with the presence of Chlamydia trachomatis DNA or rRNA in semen from male partners of infertile couples. Human Reproduction 10, 315-319.
9. Eggert-Kruse, W., Gerhard, I., Naher, H., Tilgen, W. & Runnebaum, B. (1990) Chlamydial infection - a female and/or male infertility factor? Fertility and Sterility 53, 1037-1043.
10. Eggert-Kruse, W., Buhlinger-Gopfarth, N., Rohr, G., Probst, S., Aufenanger, J., Naher, H. & Runnebaum, B. (1996) Antibodies to Chlamydia trachomatis in semen and relationship with parameters of male fertility. Human Reproduction 11, 1408-1417.
11. Eley, A., Pacey, A. A., Galdiero, M., Galdiero, M. & Galdiero, F. (2005) Can Chlamydia trachomatis directly damage your sperm? Lancet Infectious Diseases 5, 53-57.
12. Fujisawa, M., Nakano, Y., Matsui, T., Okada, H., Arakawa, S. & Kamidono, S. (1999) Chlamydia trachomatis detected by ligase chain reaction in the semen of asymptomatic patients without pyospermia or pyuria. Archives of Andrology 42, 41-44.
13. Gdoura, R., Keskes-Ammar, L., Bouzid, F., Eb, F., Hammami, A. & Orfila, J. (2001) Chlamydia trachomatis and male infertility in Tunisia. European Journal of Contraception and Reproductive Health Care 6, 102-107.
14. Gonzales, G. F., Munoz, G., Sanchez, R., Henkel, R., Gallegos-Avila, G., Diaz-Gutierrez, O. et al. (2004) Update on the impact of Chlamydia trachomatis infection on male fertility. Andrologia 36, 1-23.
15. Habermann, B. & Krause, W. (1999) Altered sperm function or sperm antibodies are not associated with chlamydial antibodies in infertile men with leucocytospermia. Journal of the European Academy of Dermatology and Venereology 12, 25-29.
16. Hosseinzadeh, S., Brewis, I. A., Eley, A. & Pacey, A. A. (2001) Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction 16, 293-299.
17. Hosseinzadeh, S., Pacey, A. A. & Eley, A. (2003) Chlamydia trachomatis-induced death of human spermatozoa is caused primarily by lipopolysaccharide. Journal of Medical Microbiology 52, 193-200.
18. Hosseinzadeh, S., Eley, A. & Pacey, A. A. (2004) Semen quality of men with asymptomatic chlamydial infection. Journal of Andrology 25, 104-109.
19. Idahl, A., Boman, J., Kumlin, U. & Olofsson, J. I. (2004) Demonstration of Chlamydia trachomatis IgG antibodies in the male partner of the infertile couple is correlated with a reduced likelihood of achieving pregnancy. Human Reproduction 19, 1121-1126.
20. Joyner, J. L., Douglas, J. M., Jr, Foster, M. & Judson, F. N. (2002) Persistence of Chlamydia trachomatis infection detected by polymerase chain reaction in untreated patients. Sexually Transmitted Diseases 29, 196-200.
21. Jungwirth, A., Straberger, A., Esterbauer, B., Fink, K. & Schmeller, N. (2003) Acrosome reaction in Chlamydia-positive and negative patients. Andrologia 35, 314-316.
22. Karinen, L., Pouta, A., Hartikainen, A. L., Bloigu, A., Paldanius, M., Leinonen, M., Saikku, P. & Jarvelin, M. R. (2004a) Antibodies to Chlamydia trachomatis heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31. American Journal of Reproductive Immunology 52, 291-297.
23. Karinen, L., Pouta, A., Hartikainen, A. L., Bloigu, A., Paldanius, M., Leinonen, M., Saikku, P. & Jarvelin, M. R. (2004b) Association between Chlamydia trachomatis antibodies and subfertility in the Northern Finland Birth Cohort 1966 (NFBC 1966), at the age of 31 years. Epidemiology and Infection 132, 977-984.
24. Krause, W. & Bohring, C. (2003) Male infertility and genital chlamydial infection: victim or perpetrator? Andrologia 35, 209-216.
25. Krieger, J. N., Riley, D. E., Roberts, M. C. & Berger, R. E. (1996) Prokaryotic DNA sequences in patients with chronic idiopathic prostatitis. Journal of Clinical Microbiology 34, 3120-3128.
26. Kvist, U. & Björndahl, L. (2002) Manual on Basic Semen Analysis. ESHRE Monographs. Oxford University Press, Oxford, UK.
27. Meinhardt, A., Parvinen, M., Bacher, M., Aumuller, G., Hakovirta, H., Yagi, A. & Seitz, J. (1995) Expression of mitochondrial heat shock protein 60 in distinct cell types and defined stages of rat seminiferous epithelium. Biology of Reproduction 52, 798-807.
28. Menkveld, R., Stander, F. S., Kotze, T. J., Kruger, T. F. & van Zyl, J. A. (1990) The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Human Reproduction 5, 586-592.
29. Neuer, A., Spandorfer, S. D., Giraldo, P., Dieterle, S., Rosenwaks, Z. & Witkin, S. S. (2000) The role of heat shock proteins in reproduction. Human Reproduction Update 6, 149-159.
30. Nyboe Andersen, A., Gianaroli, L. & Nygren, K. G. (2004) Assisted reproductive technology in Europe, 2000. Results generated from European registers by ESHRE. Human Reproduction 19, 490-503.
31. Penna Videau, S., Cermeno Vivas, J. & Salazar, N. (2001) IgA antibodies to Chlamydia trachomatis and seminal parameters in asymptomatic infertile males. Archives of Andrology 46, 189-195.
32. Satta, A., Stivala, A., Garozzo, A., Morello, A., Perdichizzi, A., Vicari, E., Salmeri, M. & Calogero, A. E. (2006) Experimental Chlamydia trachomatis infection causes apoptosis in human sperm. Human Reproduction 21, 134-137.
33. Steptoe, P. C. & Edwards, R. G. (1978) Birth after the reimplantation of a human embryo. Lancet 2, 366.
34. Taylor-Robinson, D. (2002) Mycoplasma genitalium - an update. International Journal of STD and AIDS 13, 145-151.
35. Templeton, A., Morris, J. K. & Parslow, W. (1996) Factors that affect outcome of in-vitro fertilisation treatment. Lancet 348, 1402-1406.
36. Tiitinen, A., Surcel, H. M., Halttunen, M., Birkelund, S., Bloigu, A., Christiansen, G., Koskela, P., Morrison, S. G., Morrison, R. P. & Paavonen, J. (2006) Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility. Human Reproduction 21, 1533-1538.
37. Veznik, Z., Pospisil, L., Svecova, D., Zajicova, A. & Unzeitig, V. (2004) Chlamydiae in the ejaculate: their influence on the quality and morphology of sperm. Acta Obstetricia et Gynecologica Scandinavica 83, 656-660.
38. Wagenlehner, F. M. E., Weldner, W. & Naber, K. G. (2006) Chlamydial infections in urology. World Journal of Urology 24, 4-12.
39. Weidner, W., Floren, E., Zimmermann, O., Thiele, D. & Ludwig, M. (1996) Chlamydial antibodies in semen: search for "silent" chlamydial infections in asymptomatic andrological patients. Infection 24, 309-313.
40. Werner, A., Meinhardt, A., Seitz, J. & Bergmann, M. (1997) Distribution of heat-shock protein 60 immunoreactivity in testes of infertile men. Cell and Tissue Research 288, 539-544.
41. Witkin, S. S., Kligman, I. & Bongiovanni, A. M. (1995) Relationship between an asymptomatic male genital tract exposure to Chlamydia trachomatis and an autoimmune response to spermatozoa. Human Reproduction 10, 2952-2955.
42. Wolff, H. (1995) The biologic significance of white blood cells in semen. Fertility and Sterility 63, 1143-1157.
43. World Health Organization (1999) WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Cambridge University Press, Cambridge, UK.
44. Zhang, X. S., Lue, Y. H., Guo, S. H., Yuan, J. X., Hu, Z. Y., Han, C. S., Hikim, A. P., Swerdloff, R. S., Wang, C. & Liu, Y. X. (2005) Expression of HSP105 and HSP60 during germ cell apoptosis in the heat-treated testes of adult cynomolgus monkeys (Macaca fascicularis). Frontiers in Bioscience 10, 3110-3121.