Synthesis of carbamate derivatives of iejimalides. Retention of normal antiproliferative activity and localization of binding in cancer cells

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3208-3216

  Schweitzer, Dirk ^a,b   Zhu, Junyi ^a,b   Jarori, Gotam ^a,b   Tanaka, Junichi ^b,c   Higa, Tatsuo ^b,c   Davisson, V Jo ^a,b   Helquist, Paul ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Cancer; Cell imaging microscopy; Cellular localization; Coumarin; Growth inhibition; Iejimalide; Microtubules

Indexed keywords

CARBAMIC ACID DERIVATIVE; FLUORESCENT DYE; IEJIMALIDE A; IEJIMALIDE B; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; DRUG SYNTHESIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; PROSTATE CANCER; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CARBAMATES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROLIDES; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UROCHORDATA;

EID: 33947588806     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.046     Document Type: Article

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