Inhibition of the gastric H+,K+-ATPase by plectrinone A, a diterpenoid isolated from Plectranthus barbatus Andrews

Journal of Ethnopharmacology

Volumn 111, Issue 1, 2007, Pages 1-7

  Schultz, Carla ^a   Bossolani, Myllene P ^a   Torres, Luce M B ^b   Lima Landman, Maria Teresa R ^a   Lapa, Antonio J ^a   Souccar, Caden ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Pós graduação em Biodiversidade Vegetal e Meio Ambiente   (Brazil)

Author keywords

Acid secretion; H+,K+ ATPase; Lamiaceae; Plectranthus barbatus; Plectrinone A; Rabbit gastric glands

Indexed keywords

AMINOPHENAZONE; ANTAK; BETHANECHOL; CARBON 14; DITERPENOID; HISTAMINE; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; PLANT EXTRACT; PLECTRANTHUS BARBATUS ANDREWS EXTRACT; PLECTRINONE A; PROTON PUMP; RANITIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DUODENUM; ENZYME INHIBITION; IC 50; MALE; MEDICINAL PLANT; MOUSE; MOUSE STRAIN; NONHUMAN; PLECTRANTHUSBARBATUS ANDREWS; PYLORUS LIGATION; RABBIT; STOMACH ACID SECRETION; STOMACH GLAND;

AMINOPYRINE; ANIMALS; ANTI-ULCER AGENTS; BETHANECHOL; BRAZIL; CHEMICAL FRACTIONATION; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; HISTAMINE; LAMIACEAE; MALE; MICE; MUSCARINIC AGONISTS; PLANT LEAVES; RABBITS; STOMACH;

LAMIACEAE; MUS; ORYCTOLAGUS CUNICULUS; PEUMUS BOLDUS; PLECTRANTHUS BARBATUS;

EID: 33947586102     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.09.046     Document Type: Article

References (36)

1. Abdel-Mogib M., Albar A.A., and Batterjee S.M. Chemistry of the genus Plectranthus. Molecules (2002) 271-301
2. +-ATPase. The Journal of Biological Chemistry 265 (1990) 22167-22173
3. Battochio A.P., Sartori M.S., and Coelho C.A. Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats. Acta Cirurgica Brasileira 20 (2005) 229-236
4. Berglindh T., and Öbrink K.J. A method for preparing isolated glands from the rabbit gastric mucosa. Acta Physiologica Scandinavica 96 (1976) 150-159
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1976) 248-254
6. Câmara C.C., Nascimento N.R., Macedo-Filho C.L., Almeida F.B., and Fonteles M.C. Antispasmodic effect of the essential oil of Plectranthus barbatus and some major constituents on the guinea-pig ileum. Planta Medica 69 (2003) 1080-1085
7. Costa M.C.C.D., and Nascimento S.C. Atividade citotóxica de Plectranthus barbatus Andr. (Lamiaceae). Acta Farmacêutica Bonaerense 22 (2003) 155-158
8. Fischman L.A., Skorupa L.A., Souccar C., and Lapa A.J. The water extract of Coleus barbatus Benth decreases gastric secretion in rats. Memórias do Instituto Oswaldo Cruz 86 Suppl. 2 (1991) 141-143
9. Fiske C.H., and Subbarow Y. The colorimetric determination of phosphorus. The Journal of Biological Chemistry 66 (1925) 375-400
10. - transport. Annual Review of Physiology 42 (1980) 111-126
11. +-ATPase from Scoparia dulcis, and its structure-activity relationships. Journal of Natural Products 54 (1991) 802-809
12. Kelecom A. Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with rearranged abietane skeleton from the Labiate Coleus barbatus. Tetrahedron 39 (1983) 3603-3608
13. Kerntopf M.R., Albuquerque R.L., Machado M.I.L., Matos F.J.A., and Craveiro A.A. Essential oils from leaves, stems, and roots of Plectranthus barbatus Andr. (Labiatae) grown in Brazil. Journal of Essential Oil Research 14 (2002) 101-102
14. +-adenosine triphosphatase in rats. Scandinavian Journal of Gastroenterology 30 (1995) 944-951
15. Lapa A.J., Fischman L.A., and Gamberini M.T. Inhibitors of gastric secretion from Brazilian folk medicinal plants. In: Capasso F., and Mascolo N. (Eds). Natural Drugs and the Digestive Tract (1992), Napoli 63-68
16. Lapa A.J., Mesia S.V., Souccar C., Lima-Landman M.T., Godinho R.O., and Lima T.C.M. Medicinal plant research in Latin America A report on the mechanism of the anti-acid/antiulcer activity of Stachytarpheta cayennensis Vahl. In: Verpoorte et al (Ed). 2000 Years of Natural Products Research - Past, Present and Future (2000), Leiden, The Netherlands 119-136
17. Lindberg P., Nordberg P., Alminger T., Brandstorm A., and Wallmark B. The mechanism of action of the gastric acid secretion inhibitor omeprazole. Journal of Medicinal Chemistry 29 (1986) 1327-1329
18. Lorenzi H., and Matos F.J.A. Plectranthus barbatus Andrews. In: Lorenzi H., and Matos F.J.A. (Eds). Plantas Medicinais no Brasil: Nativas e Exóticas Cultivadas (2002), SP: Instituto Plantarum, Nova Odessa 259-260
19. Lukhoba C.W., Simmonds M.S.J., and Paton A.J. Plectranthus: a review of ethnobotanical uses. Journal of Ethnopharmacology 103 (2006) 1-24
20. Matu E.N., and van Staden J. Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya. Journal of Ethnopharmacology 87 (2003) 35-41
21. +-ATPase and acid secretion by ellagic acid. Planta Medica 57 (1991) 305-308
22. +-ATPase. Planta Medica 56 (1990) 360-363
23. +-ATPase inhibition by catechins. Journal of Pharmacy and Pharmacology 44 (1992) 926-928
24. +-ATPase by flavonoids: a structure-activity study. Journal of Enzyme Inhibition 14 (1999) 151-166
25. Rabe T., and Van Staden J. Screening Plectranthus species for antibacterial activity. South African Journal of Botany 64 (1998) 62-65
26. Rüedi P. Neue Diterpene aus Blattdrüsen von Plectranthus barbatus (Labiatae). Die absolute Konfiguration der 2-Hydroxypropyl-Seitenkette in Coleon E. Helvetica Chimica Acta 69 (1986) 972-984
27. Rüedi P., and Eugster C.H. Struktur von Coleon E, einem neuen diterpenoiden Methylenchino aus der Coleus barbatus-Gruppe (Labiatae). Helvetica Chimica Acta 55 (1972) 1994-2014
28. + pump in plasma membranes of hog stomach. The Journal of Biological Chemistry 251 (1976) 7690-7698
29. Sousa M.P., Matos M.E.O., Matos F.J.A., Machado M.I.L., and Craveiro A.A. Malva-santa. In: Matos F.J.A., et al. (Eds). Constituintes Químicos Ativos e Propriedades Biológicas de Plantas Medicinais Brasileiras (2004), Ed. UFC, Fortaleza 330-335
30. Speisky H., and Cassels B.K. Boldo and boldine: an emerging case of natural drug development. Pharmacological Research 29 (1994) 1-12
31. Tamasiro V., Davino S.C., Freitas P.C.D., and Barros S.B.M. In vitro antioxidant activity of Coleus barbatus (Andr.) Benth (false boldo) and Peumus boldo (Molina) (Boldo do Chile): a comparative study. Revista de Farmácia e Bioquímica da Universidade de São Paulo vol. 34 (1998) 15-17
32. Urushidani T., and Forte J.G. Signal transduction and activation of acid secretion in the parietal cell. The Journal of Membrane Biology 159 (1997) 99-111
33. Vela S.M., Souccar C., Lima-Landman M.T., and Lapa A.J. Inhibition of gastric acid secretion by the aqueous extract and purified fractions of Stachytarpheta cayennensis Schau. Planta Medica 63 (1997) 36-39
34. +-ATPase and acid secretion by SCH 28080 a substituted pyridyl(1,2a)imidazole. The Journal of Biological Chemistry 262 (1987) 2077-2084
35. Yao X., and Forte J.G. Cell biology of acid secretion by the parietal cell. Annual Review of Physiology 65 (2003) 103-131
36. Zelnik R., Lavie D., Levy E.C., Wang A.H.-J., and Paul I.C. Barbatusin and cyclobutatusin, two novel diterpenoids from Coleus barbatus Bentham. Tetrahedron 33 (1977) 1457-1467