Transient and reversible nephrotoxicity of sarin in rats

Journal of Applied Toxicology

Volumn 27, Issue 2, 2007, Pages 189-194

  Bloch Shilderman, Eugenia ^a   Levy, Aharon ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Atropine and oxime therapy; Cholinesterase inhibition; GFR; Insecticides; Organophosphates; Renal failure; Sarin

Indexed keywords

ATROPINE; ELECTROLYTE; PENTETATE TECHNETIUM TC 99M; SARIN; TRIMEDOXIME;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLADDER BLEEDING; BLADDER DISEASE; BLADDER EDEMA; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFECT; ELECTROLYTE URINE LEVEL; ERYTHROCYTE; GLOMERULUS FILTRATION RATE; GLUCOSURIA; HEMATURIA; KIDNEY FUNCTION; LD 50; MALE; MICROSCOPY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RELATIVE DENSITY; URINALYSIS; URINE VOLUME;

ANIMALS; ANTIDOTES; ATROPINE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; GLOMERULAR FILTRATION RATE; GLYCOSURIA; HEMATURIA; KIDNEY; KIDNEY DISEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SARIN; TIME FACTORS; TRIMEDOXIME; URINALYSIS; URINARY BLADDER;

RATTUS;

EID: 33947585915     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1204     Document Type: Article

References (29)

1. Abend Y, Goland S, Evron E, Sthoeger ZM, Geltner D. 1994. Acute renal failure complicating organophosphate intoxication. Ren. Fail. 16: 415-417.
2. Albright RK, Kram BW, White RP. 1983. Malathion exposure associated with acute renal failure. J. Am. Med. Assoc. 250: 2469.
3. th Med Chem Def Biosci Rev. US Army Medical Research and Development Command, Aberdeen Proving Ground: MD, USA; 739-742.
4. Bagchi D, Bagchu M, Hassoun EA, Stohs SJ. 1995. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 104: 129-140.
5. Bardin PG, Van Eden SF, Joubert, JR. 1987. Intensive care management of acute organophosphate poisoning. A 7-year experience in the Western Cape. S. Afr. Med. J. 72: 593-597.
6. Bardin PG, Van Eden SF, Moolman J A, Foden AP, Joubert JR. 1994. Organophosphate and carbamate poisoning. Arch. Intern. Med. 154: 1433-1441.
7. Berndt WO, Baggete J, Hoskins B, Lim DK, Ho IK. 1984. Effects of diisopropylfluorophosphate (DFP) on renal function in the rat. Toxicology 31: 223-235.
8. Betrosian A, Balla M, Kafiri G, Kofinas G, Makri R, Kakouri A. 1995. Multiple system organ failure from organophosphate poisoning. Clin. Toxicol. 33: 257-260.
9. Bryan CW, Jarchow RC, Maher JF. 1972. Measurement of glomerular filtration rate in small animals without urine collection. J. Lab. Clin. Med. 80: 845-846.
10. Choppin A. 2002. Muscarinic receptors in isolated urinary smooth muscle from different mouse strains. Br. J. Pharmacol. 137: 522-528.
11. 99mTc-DTPA. Eur. J. Nucl. Med. 11: 7-12.
12. Finkelstein Y, Kushnir A, Raikhlin-Eisenkraft B, Taitelman U. 1989. Antidotal therapy of severe acute organophosphate poisoning: A multihospital study. Neurotoxicol. Teratol. 11: 593-596.
13. Futagami K, Hirano H, Iimori E, Motomura K, Ide M, Kataoka Y, Araki H, Gomita Y, Oishi R. 2001. Severe fenitrothion poisoning complicated by rhabdomyolysis in psychiatric patient. Acta Med. Okayama 55: 129-132.
14. Green MD, Tucker F, Southhall C, Clark LH. 1984. Biochemical observations in rats following exposure to soman. Proc. West Pharmacol. Soc. 27: 311-314.
15. Guven M, Oymak O, Htas C, Emekliaglu S. 1998. Rhabdomyolysis and acute renal failure due to status epilepticus. Clin. Nephrol. 50: 204.
16. Hettwer VH. 1974. Histochemisch und electronenmikroskopische Untersuchungen an Leber und Niere von Maus und Ratte nach PE.-Vergiftung, O2-Mangel und nach Hungerdiat. Forsch. Ber. Wehrtechnik 10: 1-47.
17. Hettwer VH. 1975. Changes in the ultrastructure of the rat kidney after intoxication with organophosphates. Acta Histochem. 52: 165-210.
18. Keadtisuke S, Fukuto R. 1987. Dysproteinuria induced in rats by O,O,S,-trimethyl phosphorothioate. Toxicol. Lett. 37: 33-39.
19. Kecik Y, Yorukoglu D, Saygin B, Sekerci S. 1993. A case of acute poisoning due to organophosphate insecticide. Anaesthesia 48: 141-143
20. Longhurst PA, Levendusky M. 2000. Influence of gender and oestrous cycle on in vitro contractile responses of the rat urinary bladder to cholinergic stimulation. Br. J. Pharmacol. 131: 177-184.
21. 99mTc DTPA. Kidney Int. 41: 450-454.
22. Ohbu S, Yamashina A, Takasu N, Yamaguchi T, Murai T, Nakano K, Matsui Y, Mikami R, Sakurai K, Hinohara S. 1997. Sarin poisoning on Tokyo subway. South. Med. J. 90: 587-593.
23. Okudera H. 2002. Clinical features on nerve gas terrorism in Matsumoto. J. Clin. Neurosci. 9: 17-21.
24. Poovala VS, Huang H, Salahudeen AK. 1999. Role of reactive oxygen metabolites in organophosphate-Bidrin-induced renal tubular cytotoxicity. J. Am. Soc. Nephrol. 10: 1746-1752.
25. Satar S, Satar D, Mete UO, Suchard JR, Topal M, Kaya M. 2005. Ultrastructural effects of acute organophosphate poisoning on rat kidney. Ren. Fail. 27: 623-627.
26. Shih TM, McDonough JH. 1997. Neurochemical mechanisms in soman-induced seizures. J. Appl. Toxicol. 17: 255-264.
27. Wedin GP. 1990. Nephrotoxicity of anticholinesterases. In Clinical and Experimental Toxicology of Organophosphate and Carbamates, Ballantyne B, Marrs C (eds). Butterworth-Heinemann: Oxford; 195-202.
28. Wedin GP, Pennente CM, Sachdev SS. 1984. Renal involvement in organophosphate poisoning. J. Am. Med. Assoc. 252: 1408.
29. Yamano T, Morita S. 1992. Hepatotoxicity of trichlorfon and dichlorovos in isolated rat hepatocytes. Toxicology 76: 69-77.