Effects of dipeptides having a C-terminal lysine on the cholesterol 7α-hydroxylase mRNA level in HepG2 cells

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 3, 2007, Pages 821-825

  Morikawa, Kensei ^a   Ishikawa, Kumiko ^a   Kanamaru, Yoshihiro ^a   Hori, Goro ^b   Nagaoka, Satoshi ^a  

^a GIFU UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Apolipoprotein B; Cholesterol 7 hydroxylase; Dipeptide; HepG2 cells; Lysine

Indexed keywords

CELLS; CHOLESTEROL; DISEASES; PROTEINS; RNA;

ATHEROSCLEROSIS; CHOLESTEROL-CATABOLIZING ENZYME; HYPERCHOLESTEROLEMIA;

PEPTIDES;

AMINO ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; DIPEPTIDE; LYSINE; MESSENGER RNA;

ARTICLE; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; TUMOR CELL LINE;

AMINO ACIDS; CELL LINE; CELL LINE, TUMOR; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DIPEPTIDES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LYSINE; RNA, MESSENGER;

EID: 33947582487     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60639     Document Type: Article

References (20)

1. Kannel, W. B., Castelli, W. P., Gordon, T., and McNamara, P. M., Serum cholesterol, lipoproteins, and the risk of coronary heart disease. Ann. Intern. Med., 74, 1-12 (1971).
2. Martin, M. J., Hulley, S. B., Browner, W. S., Kuller, L. H., and Wentworth, D., Serum cholesterol, blood pressure and mortality: implications from a cohort of 361,662 men. Lancet, 328, 933-936 (1986).
3. Ginsberg, H. N., Barr, S. L., Gilbert, A., Karmally, W., Deckelbaum, R., Kaplan, K., Ramakrishnan, R., Holleran, S., and Dell, R. B., Reduction of plasma cholesterol levels in normal men on an American heart association step 1 diet or a step 1 diet with added monounsaturated fat. N. Engl. J. Med., 322, 574-579 (1990).
4. Carroll, K. K., and Hamilton, R. M. G., Effects of dietary protein and carbohydrate on plasma cholesterol levels in relation to atherosclerosis. J. Food Sci., 40, 18-23 (1975).
5. Sirtori, C. R., Even, R., and Lovati, M. R., Soybean protein diet and plasma cholesterol: from therapy to molecular mechanisms. Ann. NY Acad. Sci., 676, 188-201 (1993).
6. Nagaoka, S., Futamura, Y., Miwa, K., Awano, T., Yamauchi, K., Kanamaru, Y., Kojima, T., and Kuwata, T., Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin. Biochem. Biophys. Res. Commun., 281, 11-17 (2001).
7. Nagaoka, S., Fujimura, W., Morikawa, K., Nakamura, A., Kanamaru, Y., Hori, G., Yamamoto, K., Takamura, M., Oda, M., and Shin, K., Lactostatin (IIAEK) and SPHP: new cholesterol-lowering peptides derived from food proteins. In "Dietary Fat and Risk of Common Diseases," ed. Huang, Y.-S., American Oil Chemist's Society (AOCS) Press, Champaign, pp. 168-185 (2006).
8. Goldstein, J. L., and Brown, M. S., Regulation of the mevalonate pathway. Nature, 343, 425-430 (1990).
9. Martin, K. O., Budai, K., and Javitt, N. B., Cholesterol and 27-hydroxycholesterol 7α-hydroxylation: evidence for two different enzymes. J. Lipid Res., 34, 581-588 (1993).
10. Spady, D. K., Cuthbert, J. A., Willard, M. N., and Meidell, R. S., Adenovirus-mediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol. J. Clin. Invest., 96, 700-709 (1995).
11. Spady, D. K., Cuthbert, J. A., Willard, M. N., and Meidell, R. S., Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. J. Biol. Chem., 273, 126-132 (1998).
12. Goodwin, B., Watson, M. A., Kim, H., Miao, J., Kemper, J. K., and Kliewer, S. A., Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-α. Mol. Endocrinol., 17, 386-394 (2003).
13. Schoonjans, K., and Auwerx, J., A sharper image of SHP. Nat. Med., 8, 789-791 (2002).
14. Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., and Furukawa, H., Angptl3 regulates lipid metabolism in mice. Nat. Genet., 30, 151-157 (2002).
15. Kaneko, E., Matsuda, M., Yamada, Y., Tachibana, Y., Shimomura, I., and Makishima, M., Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. J. Biol. Chem., 278, 36091-36098 (2003).
16. Morikawa, K., Kondo, I., Kanamaru, Y., and Nagaoka, S., A novel regulatory pathway for cholesterol degradation via lactostatin. Biochem. Biophys. Res. Commun., 352, 697-702 (2007).
17. Ouguerram, K., Magot, T., Zair, Y., Marchini, J. S., Charbonnel, B., Laouenan, H., and Krempf, M., Effect of atorvastatin on apolipoprotein B100 containing lipoprotein metabolism in type-2 diabetes. J. Pharmacol. Exp. Ther., 306, 332-337 (2003).
18. Snedecor, G. W., and Cochran, W. G., "Statistical Methods" 6th ed., Iowa State University Press, Ames, Japanese Edition: Iwanami, Tokyo (1967).
19. Duncan, D. B., Multiple range test for correlated and heteroscedatic means. Biometrics, 13, 164-176 (1957).
20. Lam, N. V., Chen, W., Suruga, K., Nishimura, N., Goda, T., and Yokogoshi, H., Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells. Amino Acids, 30, 43-48 (2006).