Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami

Tissue Antigens

Volumn 69, Issue 4, 2007, Pages 299-304

  Harbo, H F ^a,b   Utsi, E ^c   Lorentzen, A R ^a,b   Kampman, M T ^d,e   Celius, E G ^b   Myhr, K M ^f,g   Lie, B A ^h   Mellgren, S I ^d,e   Thorsby, E ^a,h  

^a UNIVERSITY OF OSLO   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c Karasjok Heart Center   (Norway)

^d UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^e UNIVERSITY OF TROMSØ   (Norway)

^f HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF BERGEN   (Norway)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Genetic susceptibility; HLA genes; Multiple sclerosis; Sami

Indexed keywords

HLA DQB1 ANTIGEN; HLA DR ANTIGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; HAPLOTYPE; HEREDITY; HUMAN; MALE; MORBIDITY; MULTIPLE SCLEROSIS; PREVALENCE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EID: 33947578228     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2007.00803.x     Document Type: Article

References (35)

1. Compston A. Distribution of multiple sclerosis. In: Compston A, ed. Mc Alpine's Multiple Sclerosis. London: Churchill-Livingstone, 2005: 71-112.
2. Gronlie SA, Myrvoll E, Hansen G, Gronning M, Mellgren SI. Multiple sclerosis in North Norway, and first appearance in an indigenous population. J Neurol 2000: 247: 129-33.
3. Gronning M, Mellgren SI. Multiple sclerosis in the two northernmost counties of Norway. Acta Neurol Scand 1985: 72: 321-7.
4. Alstadhaug KB, Olavsen J, Salvesen R. [Occurrence of multiple sclerosis in Nordland, 1970-1999]. Tidsskr Nor Laegeforen 2005: 125: 431-3.
5. Celius EG, Vandvik B. Multiple sclerosis in Oslo, Norway: prevalence on 1 January 1995 and incidence over a 25-year period. Eur J Neurol 2001: 8: 463-9.
6. Dahl OP, Aarseth JH, Myhr KM, Nyland H, Midgard R. Multiple sclerosis in Nord-Trondelag County, Norway: a prevalence and incidence study. Acta Neurol Scand 2004: 109: 378-84.
7. Grytten N, Glad SB, Aarseth JH, Nyland H, Midgard R, Myhr KM. A 50-year follow-up of the incidence of multiple sclerosis in Hordaland County, Norway. Neurology 2006: 66: 182-6.
8. Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 1991: 38: 1-15.
9. Spurkland A, Ronningen KS, Vandvik B, Thorsby E, Vartdal F. HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis. Hum Immunol 1991: 30: 69-75.
10. Lincoln MR, Montpetit A, Cader MZ et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 2005: 37: 1108-12.
11. Sawcer S, Ban M, MaranianMet al. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 2005: 77: 454-67.
12. The Transatlantic Multiple Sclerosis Genetics Cooperative. A meta-analysis of genomic screens in multiple sclerosis. Mult Scler 2001: 7: 3-11.
13. Caballero A, Alves-Leon S, Papais-Alvarenga R, Fernandez O, Navarro G, Alonso A. DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians. Tissue Antigens 1999: 54: 524-6.
14. Oksenberg JR, Barcellos LF, Cree BA et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet 2004: 74: 160-7.
15. Spurkland A, Celius EG, Knutsen I, Beiske A, Thorsby E, Vartdal F. The HLA-DQ (alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer. Tissue Antigens 1997: 50: 15-22.
16. Marrosu MG, Murru R, Murru MR et al. Dissection of the HLAassociation with multiple sclerosis in the founder isolated population of Sardinia. Hum Mol Genet 2001: 10: 2907-16.
17. Laaksonen M, Pastinen T, Sjoroos M et al. HLA class II associated risk and protection against multiple sclerosis-a Finnish family study. J Neuroimmunol 2002: 122: 140-5.
18. Saruhan-Direskeneli G, Esin S, Baykan-Kurt B, Ornek I, Vaughan R, Eraksoy M. HLA-DR and -DQ associations with multiple sclerosis in Turkey. Hum Immunol 1997: 55: 59-65.
19. Achilli A, Rengo C, Battaglia V et al. Saami and Berbers - an unexpected mitochondrial DNA link. Am J Hum Genet 2005: 76: 883-6.
20. Tambets K, Rootsi S, Kivisild T et al. The western and eastern roots of the Saami - the story of genetic "outliers" told by mitochondrial DNA and Y chromosomes. Am J Hum Genet 2004: 74: 661-82.
21. Evseeva I, Spurkland A, Thorsby E et al. HLA profile of three ethnic groups living in the North-Western region of Russia. Tissue Antigens 2002: 59: 38-43.
22. Torkildsen O, Utsi E, Harbo HF, Mellgren SI, Vedeler CA, Myhr KM. Ethnic variations of IL-10 polymorphisms in a Sami and Norwegian population. Scand J Immunol 2005: 62: 71-4.
23. Torkildsen O, Utsi E, Mellgren SI, Harbo HF, Vedeler CA, Myhr KM. Ethnic variation of Fc gamma receptor polymorphism in Sami and Norwegian populations. Immunology 2005: 115: 416-21.
24. Solbakk JT. Samene - en håndbok. Karasjok: Davvi Girji, 2004.
25. Kvernmo S, Heyerdahl S. Acculturation strategies and ethnic identity as predictors of behavior problems in arctic minority adolescents. J Am Acad Child Adolesc Psychiatry 2003: 42: 57-65.
26. Kvernmo S. Preventive health programs among Sami adolescents in a Sami community. Arctic Med Res 1995: 54(Suppl 1): 107-12.
27. Landtblom AM, Riise T, Kurtzke JF. Further considerations on the distribution of multiple sclerosis in Sweden. Acta Neurol Scand 2005: 111: 238-46.
28. Sarasoja T, Wikstrom J, Paltamaa J, Hakama M, Sumelahti ML. Occurrence of multiple sclerosis in central Finland: a regional and temporal comparison during 30 years. Acta Neurol Scand 2004: 110: 331-6.
29. Gusev E, Boiko A, Bikova O et al. The natural history of early onset multiple sclerosis: comparison of data from Moscow and Vancouver. Clin Neurol Neurosurg 2002: 104: 203-7.
30. Kampman MT, Wilsgaard T, Mellgren SI. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. J Neurol 2007: In press.
31. Poser CM, Paty DW, Scheinberg L et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Intern Med J 1983: 13: 227-31.
32. McDonald WI, Compston A, Edan G et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Intern Med J 2001: 50: 121-7.
33. Ballerini C, Guerini FR, Rombola G et al. HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe. J Neuroimmunol 2004: 150: 178-85.
34. Dunne C, McGuigan C, Crowley J et al. Human leucocyte antigen class II polymorphism in Irish patients with multiple sclerosis. Tissue Antigens 2006: 68: 257-62.
35. McGuigan C, Dunne C, Crowley J et al. Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland. J Neurol 2005: 252: 1245-8.