Organization of flaviviral replicase proteins in virus-induced membranes: A role for NS1′ in Japanese encephalitis virus RNA synthesis

Novartis Foundation Symposium

Volumn 277, Issue , 2006, Pages 136-145

  Satchidanandam, Vijaya ^a   Uchil, Pradeep Devappa ^a   Kumar, Priti ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

NS1 PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; NS5 PROTEIN, FLAVIVIRUS; RNA HELICASE; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; CELL MEMBRANE; CHEMISTRY; GENETICS; JAPANESE ENCEPHALITIS VIRUS; METABOLISM; RADIOIMMUNOPRECIPITATION; VIRUS REPLICATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL MEMBRANE; ENCEPHALITIS VIRUS, JAPANESE; RADIOIMMUNOPRECIPITATION ASSAY; RNA HELICASES; RNA, VIRAL; SERINE ENDOPEPTIDASES; TRYPSIN; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 33947546913     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (12)

1. Blackwell JL, Brinton MA 1997 Translation elongation factor-1 alpha interacts with the 3′ stem-loop region of West Nile virus genomic RNA. J Virol 71:6433-6444
2. Chu PW, Westaway EG 1987 Characterization of Kunjin virus RNA-dependent RNA polymerase: reinitiation of synthesis in vitro. Virology 157:330-337
3. Hayes CG 2001 West Nile virus: Uganda, 1937, to New York City, 1999. Ann N Y Acad Sci 951:25-37
4. Jia XY, Briese T, Jordan I et al 1999 Genetic analysis of West Nile New York 1999 encephalitis virus. Lancet 354:1971-1972
5. Kumar P, Uchil PD, Sulochana P et al 2003 Screening for T cell-eliciting proteins of Japanese encephalitis virus in a healthy JE-endemic human cohort using recombinant baculovirus-infected insect cell preparations. Arch Virol 148:1569-1591
6. Lindenbach BD, Rice CM 1999 Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function. J Virol 73:4611-4621
7. Mackenzie JM, Jones MK, Young PR 1996 Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication. Virology 220:232-240
8. Rice CM, Lindenbach BD (eds) 2001 Flaviviridae. Lippincott Williams and Wilkins, Philadelphia, PA
9. Ta M, Vrati S 2000 Mov34 protein from mouse brain interacts with the 3′ noncoding region of Japanese encephalitis virus. J Virol 74:5108-5115
10. Uchil PD, Satchidanandam V 2003a Architecture of the flaviviral replication complex: protease, nuclease, and detergents reveal encasement within double-layered membrane compartments. J Biol Chem 278:24388-24398
11. Uchil PD, Satchidanandam V 2003b Characterization of RNA synthesis, replication mechanism, and in vitro RNA-dependent RNA polymerase activity of Japanese encephalitis virus. Virology 307:358-371
12. Westaway EG, Mackenzie JM, Kenney MT, Jones MK, Khromykh AA 1997 Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures. J Virol 71 6650-6661