Molecular-cytogenetic characterisation of sex cord-stromal tumours: CGH analysis in sertoli cell tumours of the testis

Virchows Archiv

Volumn 450, Issue 4, 2007, Pages 425-431

  Verdorfer, I ^a   Hollrigl A ^a   Strasser, U ^a   Susani, M ^b   Hartmann, A ^c   Rogatsch, H ^a,d   Mikuz, G ^a  

^a MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

CGH; FISH; Molecular cytogenetic; Sertoli cell tumours

Indexed keywords

DNA;

ARTICLE; CARCINOGENESIS; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; DNA ISOLATION; FEMALE; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; SERTOLI CELL TUMOR; SEX CORD TUMOR; TESTIS TUMOR; X CHROMOSOME;

ADULT; AGED; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; GENOME, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; INHIBINS; KERATINS; MALE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; SERTOLI CELL TUMOR; TESTICULAR NEOPLASMS; VIMENTIN;

EID: 33947532167     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-007-0385-8     Document Type: Article

References (33)

1. Aly MS, Dal Cin P, Moerman P, De Wever I, Devriendt K, Brock P, Casteels-Van-Daele M, Van den Berghe H (1993) Loss of the Y-chromosome in a malignant sertoli tumor. Cancer Genet Cytogenet 65:104-106
2. Augusto D, Leteurtre E, De La Taille A, Gosselin B, Leroy X (2002) Calretinin: a valuable marker of normal and neoplastic Leydig cells of the testis. Appl Immunohistochem Mol Morphol 10:159-162
3. Conkey DS, Howard GC, Grigor KM, McLaren DB, Kerr GR (2005) Testicular sex cord-stromal tumours: the Edinburgh experience 1988-2002, and a review of the literature. Clin Oncol 17:322-327
4. Glaser D, Nienhaus H, Kohler R, Walther G, Pawlowitzki IH (1988) A sex cord stromal tumour in a woman with X0/XX/XXX-mosaicism. Arch Gynecol Obstet 243:115-118
5. Gurer IE, Demirkiran AE, Sare M (2000) Sertoli cell tumor in two sibs with testicular feminization syndrome. Turk J Med Sci 30:385-387
6. Henley JD, Young RH, Ulbright TM (2002) Malignant sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. Am J Surg Pathol 26:541-550
7. Hitosugi M, Matsuoka Y, Irimajiri S, Fukada J (1997) Sertoli-Leydig cell tumour complicated by X chromosomal mosaicism. Clin Endocrinol (Oxf) 47:619-622
8. Jayasena SN, Ariyasinghe JT, Gunawardena DM, Gunawardena SA, de Silva MV (2005) Large-cell calcifying sertoli cell tumour of the testis detected at screening of a family with Carney syndrome. Urol Int 75:365-367
9. Kara C, Kutlu AO, Tosun MS, Apaydin S, Senel F (2005) Sertoli cell tumor causing prepubertal gynecomastia in a boy with Peutz-Jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. Horm Res 63:252-256
10. Karabulut N, Karabulut A, Pakdemirli E, Sabir N, Soysal SK, Soysal ME (2002) Stromal tumor of the sex cord in a woman with testicular feminization syndrome: imaging features. Am J Roentgenol 178:1496-1498
11. Kato N, Fukase M, Motoyama T (2004) Expression of a transcription factor, SOX9, in Sertoli-stromal cell tumors of the ovary. Int J Gynecol Pathol 23:180-181
12. Kato N, Fukase M, Ono I, Matsumoto K, Okazaki E, Motoyama I (2001) Sertoli-stromal cell tumor of the ovary: immunohistochemical, ultrastructural, and genetic studies. Hum Pathol 32:796-802
13. Kato N, Romero M, Catasus L, Prat J (2004) The STK11/LKB1 Peutz-Jegher gene is not involved in the pathogenesis of sporadic sex cord-stromal tumors, although loss of heterozygosity at 19p13.3 indicates other gene alteration in these tumors. Hum Pathol 35:1101-1104
14. Kawakami T, Okamoto K, Sugihara H, Hattori T, Reeve AE, Ogawa O, Okada Y (2003) The roles of supernumerical X chromosome and XIST expression in testicular germ cell tumors. J Urol 169:1546-1552
15. Kolon TF, Hochman HI (1997) Malignant sertoli cell tumor in a prepubescent boy. J Urol 158:608-609
16. Kratzer S, Ulbright T, Talermann A, Srigley JR, Roth LM, Wahle GR, Moussa M, Stephens JK, Millos A, Young RH (1997) Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature. Am J Surg Pathol 21:1271-1280
17. Kuroda N, Senzaki T, Yamasaki Y, Miyazaki E, Hayashi Y, Toi M, Hiroi M, Enzan H (2004) Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-α. Pathol Int 54:719-724
18. Looijenga LH, Oosterhuis JW (2004) Clinical value of the X chromosome in testicular germ-cell tumours. Lancet 363:6-8
19. Matyakhina L, Pack S, Kirschner LS, Pak E, Mannan P, Jaikumar J, Taymans SE, Sandrini F, Carney JA, Stratakis CA (2003) Chromosome 2 (2p16) abnormalities in Carney complex tumours. J Med Genet 40:268-277
20. Oliva E, Alvarez T, Young RH (2005) Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am Surg Pathol 29:143-156
21. Patael-Karasik Y, Daniely M, Gotlieb WH, Ben-Baruch G, Schiby J, Barakai G, Goldman B, Aviram A, Friedman E (2000) Comparative genomic hybridization in inherited and sporadic ovarian tumors in Israel. Cancer Genet Cytogenet 121:26-32
22. Pejovic T, Heim S, Alm P, Iosif S, Himmelmann A, Skjaerris J, Mitelman F (1993) Isochromosome 1q as the sole karyotypic abnormality in a Sertoli cell tumor of the ovary. Cancer Genet Cytogenet 65:79-80
23. Sandrini F, Stratakis C (2003) Clinical and molecular genetics of Carney complex. Mol Genet Metab 78:83-92
24. Sato K, Ueda Y, Sakurai A, Ishikawa Y, Okamoto SY, Ikawa H, Katsuda S (2005) Large cell calcifying Sertoli cell tumor of the testis: comparative immunohistochemical study with Leydig cell tumor. Pathol Int 55:366-371
25. Sesterhenn IA, Cheville J, Woodward PJ, Damjanov I, Jacobsen GK, Nistal M, Paniagua R, Renshaw AA (2004) Sex cord/gonadal stromal tumours. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) Pathology and genetics. Tumours of the urinary system and male genital organs. IARC, Lyon, pp 250-258
26. Talerman A (1971) Malignant sertoli cell tumor of the testis. Cancer 28:446-455
27. Talon I, Moog R, Kauffmann I, Grandadam S, Becmeur F (2005) Sertoli cell tumor of the testis in children: reevaluation of a rarely encountered tumor. J Pediatr Hematol Oncol 27:491-494
28. Tanaka Y, Yamaguchi M, Ijiri R, Kondo I (1999) Malignant large cell calcifying sertoli cell tumor with endocrine overactivity. J Urol 161:1575
29. Ulbright TM, Amin MB, Young RH (1999) Tumors of the testis, adnexa, spermatic cord, and scrotum. AFIP atlas of tumor pathology, 3rd series, Fascicle 25. Washington, DC
30. Verdorfer I, Rogatsch H, Tzankov A, Steiner H, Mikuz G (2004) Molecular cytogenetic analysis of human spermatocytic seminomas. J Pathol 204:277-281
31. Wolff E, Girod S, Liehr T, Vorderwulbecke U, Ries J, Steininger H, Gebhart E (1998) Oral squamous cell carcinomas are characterized by a rather uniform pattern of genomic imbalances detected by comparative genomic hybridisation. Oral Oncol 34:186-190
32. Young RH (2005) Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol 18:81-98
33. Young RH, Koelliker DD, Scully RE (1998) Sertoli cell tumors of the testis, not otherwise specified: a clinicopathologic analysis of 60 cases. Am J Surg Pathol 22:709-721