Orthodromic spike generation from electrical stimuli in the rat carotid body: Implications for the afferent spike generation process

Journal of Physiology

Volumn 580, Issue 1, 2007, Pages 275-284

  Donnelly, David F ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAROTID BODY; ELECTRODE; ELECTROSTIMULATION; EVOKED RESPONSE; HYPEROXIA; NERVE CELL EXCITABILITY; NERVE ENDING; NERVE POTENTIAL; NEUROMODULATION; NONHUMAN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; PROBABILITY; RAT; SENSORY NERVE CELL; SPATIAL SUMMATION; SPIKE WAVE; STIMULUS RESPONSE; SYNAPTIC POTENTIAL; VARIANCE; CAROTID BODY CHEMORECEPTOR; CONTROLLED STUDY; SENSORY NERVE; SPIKE; SYNAPTIC DEPOLARIZING POTENTIAL;

ALGORITHMS; ANIMALS; ANOXIA; CAROTID BODY; CHEMORECEPTORS; ELECTRIC STIMULATION; HYPEROXIA; NEURONS, AFFERENT; PRESYNAPTIC TERMINALS; RATS; SYNAPTIC TRANSMISSION;

EID: 33947525551     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.119263     Document Type: Article

References (29)

1. Bhadra N & Kilgore KL (2004). Direct current electrical conduction block of peripheral nerve. IEEE Trans Neural Syst Rehabil Eng 12, 313-324.
2. Buckler KJ (1997). A novel oxygen-sensitive potassium current in rat carotid body type I cells. J Physiol 498, 649-662.
3. Chow CC & White JA (1996). Spontaneous action potentials due to channel fluctuations. Biophys J 71, 3013-3021.
4. + currents of petrosal neurons with projections to the carotid body. J Neurophysiol 88, 2993-3002.
5. Donnelly DF (1996). Chemoreceptor nerve excitation may not be proportional to catecholamine secretion. J Appl Physiol 81, 657-664.
6. Donnelly DF & Doyle TP (1994). Developmental changes in hypoxia-induced catecholamine release from rat carotid body, in vitro. J Physiol 475, 267-275.
7. Donnelly DF, Panisello JM & Boggs D (1998). Effect of sodium perturbations on rat chemoreceptor spike generation: Implications for a Poisson model. J Physiol 511, 301-311.
8. Donnelly DF & Rigual R (2000). Single-unit recordings of arterial chemoreceptors from mouse petrosal ganglia in vitro. J Appl Physiol 88, 1489-1495.
9. Faustino EV & Donnelly DF (2006). An important functional role of persistent sodium current in carotid body hypoxia transduction. J Appl Physiol 101, 1076-1084.
10. Gallego R, Eyzaguirre C & Monti-Bloch L (1979). Thermal and osmotic responses of arterial receptors. J Neurophysiol 42, 665-680.
11. Gronblad M (1983). Improved demonstration of exocytotic profiles in glomus cells of rat carotid body after perfusion with glutaraldehyde fixative containing a high concentration of potassium. Cell Tissue Res 229, 627-637.
12. Hales JP, Lin CS & Bostock H (2004). Variations in excitability of single human motor axons, related to stochastic properties of nodal sodium channels. J Physiol 559, 953-964.
13. Hammarstrom AKM & Gage PW (2000). Oxygen-sensing persistent sodium channels in rat hippocampus. J Physiol 529, 107-118.
14. Hayashida Y, Koyano H & Eyzaguirre C (1980). An intracellular study of chemosensory fibers and endings. J Neurophysiol 44, 1077-1088.
15. Horn EM & Waldrop TG (2000). Hypoxic augmentation of fast-inactivating and persistent sodium currents in rat caudal hypothalamic neurons. J Neurophysiol 84, 2572-2581.
16. Iturriaga R & Alcayaga J (2004). Neurotransmission in the carotid body: Transmitters and modulators between glomus cells and petrosal ganglion nerve terminals. Brain Res Brain Res Rev 47, 46-53.
17. Ju YK, Saint DA & Gage PW (1996). Hypoxia increases persistent sodium current in rat ventricular myocytes. J Physiol 497, 337-347.
18. Kline DD, Yang T, Huang PL & Prabhakar NR (1998). Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol 511, 273-287.
19. Lopez-Barneo J, Lopez-Lopez JR, Urena J & Gonzalez C (1988). Chemotransduction in the carotid body: K current modulated by pO2 in type I chemoreceptor cells. Science 241, 580-582.
20. + current. Neurosci Lett 119, 253-256.
21. Raman IM, Sprunger LK, Meisler MH & Bean BP (1997). Altered subthreshold sodium currents and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19, 881-891.
22. 2+ currents. Pflugers Arch 439, 463-470.
23. Rong W, Gourine AV, Cockayne DA, Xiang Z, Ford APDW, Spyer KM & Burnstock G (2003). Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci 23, 11315-11321.
24. Rubinstein JT (1995). Threshold fluctuations in an N sodium channel model of the node of Ranvier. Biophys J 68, 779-785.
25. 2+ response of carotid chemoreceptor cells to hypoxia. Am J Physiol Lung Cell Mol Physiol 268, L801-L808.
26. Verna A (1997). The mammalian carotid body: Morphological data. In The Carotid Body Chemoreceptors, ed. Gonzalez C, pp. 1-29. Springer, Heidelberg, Germany.
27. Verna A, Roumy M & Leitner LM (1975). Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells. Brain Res 100, 13-23.
28. Zhang M, Zhong H, Vollmer C & Nurse CA (2000). Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J Physiol 525, 143-158.
29. Zhong H, Zhang M & Nurse CA (1997). Synapse formation and hypoxic signalling in co-cultures of rat petrosal neurones and carotid body type 1 cells. J Physiol 503, 599-612.