Global correlation of genome and transcriptome changes in classical Hodgkin lymphoma

Hematological Oncology

Volumn 25, Issue 1, 2007, Pages 21-29

  Kluiver, Joost ^a   Kok, Klaas ^a   Pfeil, Ines ^b   De Jong, Debora ^a   Blokzijl, Tjasso ^a   Harms, Geert ^a   Van Der Vlies, Pieter ^a   Diepstra, Arjan ^a   Atayar, Çiǧdem ^a   Poppema, Sibrand ^a   Küppers, Ralf ^c   Van Den Berg, Anke ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Array based CGH; FSCN1; Hodgkin lymphoma; IRAK1; SAGE

Indexed keywords

DNA; FASCIN; HLA ANTIGEN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; JANUS KINASE 2; TRANSCRIPTION FACTOR REL; TRANSCRIPTOME;

ARTICLE; CHROMOSOME 11Q; CHROMOSOME 2P; CHROMOSOME 4Q; CHROMOSOME 7P; CHROMOSOME 9P; CHROMOSOME LOSS; CHROMOSOME XQ; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE OVEREXPRESSION; GENOME; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SERIAL ANALYSIS OF GENE EXPRESSION;

CARRIER PROTEINS; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENES, NEOPLASM; HLA ANTIGENS; HODGKIN DISEASE; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; JANUS KINASE 2; MICROFILAMENT PROTEINS; NUCLEIC ACID HYBRIDIZATION; PROTO-ONCOGENE PROTEINS C-REL; RNA, NEOPLASM; UP-REGULATION;

EID: 33947503691     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.804     Document Type: Article

References (44)

1. Küppers R, Rajewsky K, Zhao M, et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 1994; 91: 10962-10966.
2. Kanzler H, Küppers R, Hansmann ML, Rajewsky K. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 1996; 184: 1495-1505.
3. Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med 1997; 337: 453-458.
4. Bräuninger A, Küppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proc Natl Acad Sci USA 1997; 94: 9337-9342.
5. Re D, Zander T, Diehl V, Wolf J. Genetic instability in Hodgkin's lymphoma. Ann Oncol 2002; 13(Suppl. 1):19-22.
6. Falzetti D, Crescenzi B, Matteuci C, et al. Genomic instability and recurrent breakpoints are main cytogenetic findings in Hodgkin's disease. Haematologica 1999; 84: 298-305.
7. Joos S, Kupper M, Ohl S, et al. Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res 2000; 60: 549-552.
8. Joos S, Menz CK, Wrobel G, et al. Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood 2002; 99: 1381-1387.
9. Martin-Subero JI, Gesk S, Harder L, et al. Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. Blood 2002; 99: 1474-1477.
10. Barth TF, Martin-Subero JI, Joos S, et al. Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma. Blood 2003; 101: 3681-3686.
11. Chui DT, Hammond D, Baird M, Shield L, Jackson R, Jarrett RF. Classical Hodgkin lymphoma is associated with frequent gains of 17q. Genes Chromosomes Cancer 2003; 38: 126-136.
12. Joos S, Granzow M, Holtgreve-Grez H, et al. Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. Int J Cancer 2003; 103: 489-495.
13. Franke S, Wlodarska I, Maes B, et al. Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances. Blood 2001; 97: 1845-1853.
14. Kapp U, Yeh WC, Patterson B, et al. Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells. J Exp Med 1999; 189: 1939-1946.
15. Kuppers R, Klein U, Schwering I, et al. Identification of Hodgkin and Reed-Sternberg cell-specific genes by gene expression profiling. J Clin Invest 2003; 111: 529-537.
16. Devilard E, Bertucci F, Trempat P, et al. Gene expression profiling defines molecular subtypes of classical Hodgkin's disease. Oncogene 2002; 21: 3095-3102.
17. Cossman J, Annunziata CM, Barash S, et al. Reed-Sternberg cell genome expression supports a B-cell lineage. Blood 1999; 94: 411-416.
18. Schwering I, Bräuninger A, Distler V, et al. Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genes. Mol Med 2003; 9: 85-95.
19. Schwering I, Bräuninger A, Klein U, et al. Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 2003; 101: 1505-1512.
20. Atayar C, Kok K, Kluiver J, et al. BCL6 ABR break and homozygous deletion of 17q24 in the nodular lymphocyte predominance type Hodgkin lymphoma derived cell line DEV. Hum Pathol 2006; 37: 675-683.
21. Kok K, Dijkhuizen T, Swart YE, et al. Application of a comprehensive subtelomere array in clinical diagnosis of mental retardation. Eur J Med Genet 2005; 48: 250-262.
22. Van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17: 2257-2317.
23. Boon K, Osorio EC, Greenhut SF, et al. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci USA 2002; 99: 11287-11292.
24. Piper J, Rutovitz D, Sudar D, et al. Computer image analysis of comparative genomic hybridization. Cytometry 1995; 19: 10-26.
25. Bentz M, Plesch A, Stilgenbauer S, Dohner H, Lichter P. Minimal sizes of deletions detected by comparative genomic hybridization. Genes Chromosomes Cancer 1998; 21: 172-175.
26. Herbst H, Dallenbach F, Hummel M, et al. Epstein-Barr virus latent membrane protein expression in Hodgkin and Reed-Sternberg cells. Proc Natl Acad Sci USA 1991; 88: 4766-4770.
27. Vockerodt M, Belge G, Kube D, et al. An unbalanced translocation involving chromosome 14 is the probable cause for loss of potentially functional rearranged immunoglobulin heavy chain genes in the Epstein-Barr virus-positive Hodgkin's lymphoma-derived cell line L591. Br J Haematol 2002; 119: 640-646.
28. Küppers R, Bräuninger A. Reprogramming of the tumour B-cell phenotype in Hodgkin lymphoma. Trends Immunol 2006. 27: 203-205.
29. Mathas S, Janz M, Hummel F, et al. Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma. Nat Immunol 2006; 7: 207-215.
30. Doerr JR, Malone CS, Fike FM, et al. Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines. J Mol Biol 2005; 350: 631-640.
31. Ushmorov A, Leithauser F, Sakk O, et al. Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma. Blood 2006; 107: 2493-2500.
32. Pinkus GS, Pinkus JL, Langhoff E, et al. Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? Am J Pathol 1997; 150: 543-562.
33. Adams JC, Schwartz MA. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J Cell Biol 2000; 150: 807-822.
34. Xie JJ, Xu LY, Zhang HH, et al. Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. Biochem Biophys Res Commun 2005; 337: 355-362.
35. Cao Z, Henzel WJ, Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996; 271: 1128-1131.
36. Bargou RC, Leng C, Krappmann D, et al. High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 1996; 87: 4340-4347.
37. Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT. Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Oncogene 1999; 18: 3063-3070.
38. Annunziata CM, Safiran YJ, Irving SG, Kasid UN, Cossman J. Hodgkin disease: pharmacologic intervention of the CD40-NF kappa B pathway by a protease inhibitor. Blood 2000; 96: 2841-2848.
39. Jungnickel B, Staratschek-Jox A, Bräuninger A, et al. Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma. J Exp Med 2000; 191: 395-402.
40. Horie R, Watanabe T, Morishita Y, et al. Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells. Oncogene 2002; 21: 2493-2503.
41. Emmerich F, Theurich S, Hummel M, et al. Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. J Pathol 2003; 201: 413-420.
42. Poppema S, Visser L. Absence of HLA class I expression by Reed-Sternberg cells. Am J Pathol 1994; 145: 37-41.
43. Bosshart H, Jarrett RF. Deficient major histocompatibility complex class II antigen presentation in a subset of Hodgkin's disease tumor cells. Blood 1998; 92: 2252-2259.
44. Diepstra A, Poppema S, te Meerman GJ, et al. Polymorphisms and lack of or aberrant expression of HLA class I and II may influence antigen presentation in classical Hodgkin lymphoma. Blood 2005; 106: 11a.