High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxis

Thrombosis and Haemostasis

Volumn 97, Issue 2, 2007, Pages 171-175

  Baba Ahmed, Mohamed ^a   Le Gal, Grégorie ^a   Couturaud, Francis ^a   Lacut, Karine ^a   Oger, Emmauel ^a   Leroyer, Christophe ^a,b  

^a BREST UNIVERSITY HOSPITAL   (France)

^b SERVICE DE RHUMATOLOGIE   (France)

Author keywords

Factor V Leiden; Orthopaedic surgery; Pulmonary embolism; Risk factors; Surgery; Venous thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; DNA; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; FREQUENCY ANALYSIS; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; ORTHOPEDIC SURGERY; PRIORITY JOURNAL; SURGICAL PATIENT; SURGICAL TECHNIQUE; THROMBOSIS PREVENTION; VENOUS THROMBOEMBOLISM; FRANCE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; LUNG EMBOLISM; MIDDLE AGED; POINT MUTATION; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; RISK; RISK FACTOR; THROMBOEMBOLISM; TREATMENT FAILURE; VEIN THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; CASE-CONTROL STUDIES; FACTOR V; FEMALE; FRANCE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; ORTHOPEDIC PROCEDURES; POINT MUTATION; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOEMBOLISM; TREATMENT FAILURE; VENOUS THROMBOSIS;

EID: 33947502255     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-11-0616     Document Type: Article

References (24)

1. Joseph JE, Low J, Courtenay B, et al. A single-centre prospective study of clinical and haemostatic risk factors for venous thromboembolism following lower limb arthroplasty. Br J Haematol 2005; 129: 87-92.
2. Josa M, Siouffi SY, Silverman AB, et al. Pulmonary embolism after cardiac surgery. J Am Coll Cardiol 1993; 21: 990-996.
3. Piriou V, Rossignol B, Laroche JP, et al. Prevention of venous thromboembolism following cardiac, vascular or thoracic surgery. Ann Fr Anesth Reanim 2005; 24: 938-946.
4. Rosendaal FR. Venous thrombosis: prevalence and interaction of risk factors. Haemostasis 1999; 29 (Suppl S1): 1-9.
5. Bertina. RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
6. Dahlback B. Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis. Thromb Haemost 1997; 78: 483-488.
7. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134.
8. Koster T, Rosendaal FR, de Ronde H, et al. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-1506.
9. Ridker PM, Hennekens CH, Lindpaintner K, et al. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-917.
10. Rosendaal FR, Koster T, Vandenbroucke JP, et al. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-1508.
11. Ehrenforth S, Nemes L, Mannhalter C, et al. Impact of environmental and hereditary risk factors on the clinical manifestation of thrombophilia in homozygous carriers of factor V:G1691A. J Thromb Haemost 2004; 2: 430-436.
12. Lowe GD, Haverkate F, Thompson SG, et al. Prediction of deep vein thrombosis after elective hip replacement surgery by preoperative clinical and haemostatic variables: the ECAT DVT Study. European Concerted Action on Thrombosis. Thromb Haemost 1999; 81: 879-886.
13. Lindahl TL, Lundahl TH, Nilsson L, et al. APC-resistance is a risk factor for postoperative thromboembolism in elective replacement of the hip or knee - a prospective study. Thromb Haemost 1999; 81: 18-21.
14. Woolson ST, Zehnder JL, Maloney WJ. Factor V Leiden and the risk of proximal venous thrombosis after total hip arthroplasty. J Arthroplasty 1998; 13: 207-210.
15. Ryan DH, Crowther MA, Ginsberg JS, et al. Relation of factor V Leiden genotype to risk for acute deep venous thrombosis after joint replacement surgery. Ann Intern Med 1998; 128: 270-276.
16. Wahlander K, Larson G, Lindahl TL, et al. Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery. Thromb Haemost 2002; 87: 580-585.
17. Philipp CS, Dilley A, Saidi P, et al. Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty. Thromb Haemost 1998; 80: 869-873.
18. Oger E, Lacut K, Le Gal G, et al. Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study. J Thromb Haemost 2006; 4: 793-799.
19. Clagett GP, Anderson FA, Jr., Geerts W, et al. Prevention of venous thromboembolism. Chest 1998; 114 (5 Suppl): 531S-560S.
20. Geerts WH, Heit JA, Clagett GP, et al. Prevention of venous thromboembolism. Chest 2001; 119 (1 Suppl): 132S-175S.
21. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126 (3 Suppl): 338S-400S.
22. Leroyer C, Mercier B, Escoffire M, et al. Factor V Leiden prevalence in venous thromboembolism patients. Chest 1997; 111: 1603-1606.
23. Svensson PJ, Benoni G, Fredin H, et al. Female gender and resistance to activated protein C (FV:Q506) as potential risk factors for thrombosis after elective hip arthroplasty. Thromb Haemost 1997; 78: 993-996.
24. Westrich GH, Weksler BB, Glueck CJ, et al. Correlation of thrombophilia and hypofibrinolysis with pulmonary embolism following total hip arthroplasty: an analysis of genetic factors. J Bone Joint Surg Am 2002; 84-A (12): 2161-2167.