Acid-base regulation of bone metabolism

International Congress Series

Volumn 1297, Issue , 2007, Pages 255-267

  Arnett, Timothy R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acidosis; Bone; Hypoxia; Osteoblasts; Osteoclasts; Oxygen; pH; Vasculature

Indexed keywords

EID: 33947496660     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2006.08.005     Document Type: Article

References (72)

1. Martin G.R., and Jain R.K. Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res. 54 (1994) 5670-5674
2. Barzel U.S. The skeleton as an ion-exchange system-implications for the role of acid-base imbalance in the genesis of osteoporosis. J. Bone Miner. Res. 10 (1995) 1431-1436
3. Macdonald H.M., et al. Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women. Am. J. Clin. Nutr. 81 (2005) 923-933
4. New S.A., et al. Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women. Am. J. Clin. Nutr. 79 (2004) 131-138
5. Buclin T., et al. Diet acids and alkalis influence calcium retention in bone. Osteoporosis Int. 12 (2001) 493-499
6. Yates A.J., et al. Inhibition of bone resorption by inorganic phosphate is mediated by both reduced osteoclast formation and decreased activity of mature osteoclasts. J. Bone Miner. Res. 6 (1991) 473-478
7. Sebastian A., et al. Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N. Engl. J. Med. 330 (1994) 1776-1781
8. Burckhardt P. Mineral waters and bone health. Rev. Med. Suisse Romande 124 (2004) 101-103
9. Dawson-Hughes, et al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N. Engl. J. Med. 323 (1990) 878-883
10. Reid I.R., et al. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. Am. J. Med. 98 (1995) 331-335
11. Ginty F., et al. The effect of short-term calcium supplementation on biochemical markers of bone metabolism in healthy young adults. Br. J. Nutr. 80 (1998) 437-443
12. Scopacasa F., et al. Inhibition of bone resorption by divided-dose calcium supplementation in early postmenopausal women. Calcif. Tissue Int. 67 (2000) 440-442
13. Frassetto L.A., and Sebastian A. Age and systemic acid-base equilibrium: analysis of published data. J. Gerontol. 51A (1996) B91-B99
14. Frassetto L.A., et al. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am. J. Physiol. 271 (1996) F1114-F1122
15. Marie P.J. Strontium ranelate: a physiological approach for optimizing bone formation and resorption. Bone 38 2 Suppl 1 (2006) S10-S14
16. Wetter T.J., et al. Effects of exhaustive endurance exercise on pulmonary gas exchange and airway function in women. J. Appl. Physiol. 91 (2001) 847-858
17. Ratel S., et al. Acid-base balance during repeated cycling sprints in boys and men. J. Appl. Physiol. 92 (2002) 479-485
18. Nichols J.F., et al. Low bone mineral density in highly trained male master cyclists. Osteoporosis Int. 14 (2003) 644-649
19. Yildizdas D., et al. Bone mineral changes in acute metabolic acidosis due to acute gastroenteritis. Calcif. Tissue Int. 75 (2004) 380-383
20. Belinsky G., and Tashjian Jr. A.H. Direct measurement of hormone-induced acidification in intact bone. J. Bone Miner. Res. 15 (2000) 550-556
21. Barrett M.G., et al. A new action of parathyroid hormone: receptor-mediated stimulation of extracellular acidification in human osteoblast-like SaOS-2 cells. J. Biol. Chem. 272 (1997) 26346-26353
22. Santhanagopal S.J.D. Insulin-like growth factor I rapidly enhances acid efflux from osteoblastic cells. Am. J. Physiol. 277 (1999) E423-E432
23. Goto K. Mineral metabolism in experimental acidosis. J. Biol. Chem. 36 (1918) 355-376
24. Jaffe H.L., et al. Ammonium chloride decalcification as modified by calcium intake: the relationship between generalized osteoporosis and ostitis fibrosa. J. Exp. Med. 56 (1932) 823-834
25. Lemann Jr. J., et al. The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. J. Clin. Invest. 45 (1966) 1608-1614
26. Relman A.S. The acidosis of renal disease. Am. J. Med. 44 (1968) 706-713
27. Barzel U.S., and Jowsey J J. The effects of chronic acid and alkali administration on bone turnover in adult rats. Clin. Sci. 36 (1969) 517-524
28. Avioli L.V. Renal osteodystrophy. In: Avioli L.V., and Krane S.M. (Eds). Metabolic Bone Disease vol. II (1978), Academic Press, New York 149-215
29. Cunningham J., et al. Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism. Am. J. Med. 73 (1982) 199-204
30. Arnett T.R., and Dempster D.W. Perspectives: protons and osteoclasts. J. Bone Miner. Res. 5 (1990) 1099-1103
31. Bushinsky D.A., et al. Effects of pH on bone calcium and proton fluxes in vitro. Am. J. Physiol. 245 (1983) F204-F209
32. Bushinsky D.A., and Lechleider R.J. Mechanism of proton-induced bone calcium release: calcium carbonate-dissolution. Am. J. Physiol. 253 (1987) F998-F1005
33. Green J., and Kleeman C.R. Role of bone in regulation of systemic acid-base balance. Kidney Int. 39 (1991) 9-26
34. Arnett T.R., and Dempster D.W. Effect of pH on bone resorption by rat osteoclasts in vitro. Endocrinology 119 (1986) 119-124
35. Arnett T.R., and Spowage M. Modulation of the resorptive activity of rat osteoclasts by small changes in extracellular pH near the physiological range. Bone 18 (1996) 277-279
36. Arnett T.R., and Dempster D.W. A comparative study of disaggregated chick and rat osteoclasts in vitro: effects of calcitonin and prostaglandins. Endocrinology 120 (1987) 602-608
37. Brandao-Burch, and Arnett T.R. Normal human osteoclasts are activated by acidosis. J. Bone Miner. Res. 19 (2004) 1034 (abstract)
38. Hoebertz A., and Arnett T.R. Isolated osteoclast cultures. Methods Mol. Med. 80 (2003) 53-64
39. Morrison M., et al. ATP is a potent stimulator of the activation and formation of rodent osteoclasts. J. Physiol. 511 (1998) 495-500
40. + stimulation of cell-mediated bone resorption in tissue culture. Am. J. Physiol. 253 (1987) E90-E98
41. Meghji S., et al. pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis. Am. J. Physiol. 280 (2001) E112-E119
42. Ludwig M.G., et al. Proton-sensing G-protein-coupled receptors. Nature 425 (2003) 93-98
43. Gasser JA, et al., Reduced BMD in mice lacking the pH-sensing receptor TDAG8, J. Bone Mineral Res. (2006) (abstract, in press).
44. Jahr H., et al. Identification of acid-sensing ion channels in bone. Biochem. Biophys. Res. Commun. 337 (2005) 349-354
45. Julius, and Basbaum A.I. Molecular mechanisms of nociception. Nature 413 (2001) 203-210
46. Holzer P. TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia. Eur. J. Pharmacol. 500 (2004) 231-241
47. Mantyh P.W., et al. Molecular mechanisms of cancer pain. Nature Rev. 2 (2002) 201-209
48. Ghilardi J.R., et al. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J. Neurosci. 25 (2005) 3126-3131
49. Brandao-Burch A., et al. Capsaicin is a potent activator of human osteoclasts. Calcif. Tissue Int. 78 (2006) S36
50. Offley S.C., et al. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J. Bone Miner. Res. 20 (2005) 257-267
51. Donnerer J., et al. Absorption and metabolism of capsaicinoids following intragastric administration in rats. Naunyn Schmiedeberg's Arch. Pharmacol. 342 (1990) 357-361
52. Andersson DA D.A., et al. TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J. Neurosci. 24 (2004) 5364-5369
53. Muhlbauer R., et al. Common herbs, essential oils and monoterpenes potently modulate bone metabolism. Bone 32 (2003) 372-380
54. + ATPase activity in osteoclasts. J. Biol. Chem. 272 (1997) 6354-6360
55. Biskobing DM D.M., and Fan D. Acid pH increases carbonic anhydrase II and calcitonin receptor mRNA expression in mature osteoclasts. Calcif. Tissue Int. 67 (2000) 178-183
56. Komarova S.V., et al. Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 2643-2648
57. Brandao-Burch, et al. Acidosis strongly upregulates mRNA for cathepsin K, TRAP and TRAF-6 in bone. Calcif. Tissue Int. 72 (2003) 364 (abstract)
58. Bushinsky D.A. Stimulated osteoclastic and suppressed osteoblastic activity in metabolic but not respiratory acidosis. Am. J. Physiol. 268 (1995) C80-C88
59. Frick K.K., and Bushinsky D.A. In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression. Am. J. Physiol. 277 (1999) F750-F755
60. Brandao-Burch, et al. Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralisation. Calcif. Tissue Int. 77 (2005) 167-174
61. Wrong O., et al. Distal renal tubular acidosis: alkali heals osteomalacia and increases net production of 1,25-dihydroxyvitamin D. Nephron Physiol. 101 (2005) 72-76
62. Bridgeman G., and Brookes M. Blood supply to the human femoral diaphysis in youth and senescence. J. Anat. 188 (1996) 611-621
63. Ishikawa Y., and Ito T. Kinetics of hemopoietic stem cells in a hypoxic culture. Eur. J. Haematol. 40 (1988) 126-129
64. Harrison J.S., et al. Oxygen saturation in the bone marrow of healthy volunteers. Blood 99 (2002) 394
65. Arnett T.R., et al. Hypoxia is a major stimulator of osteoclast formation and bone resorption. J. Cell. Physiol. 196 (2003) 2-8
66. Utting J.C., et al. Severe hypoxia increases osteoclast formation from human peripheral blood: amplification of resorption by acidosis. Calcif. Tissue Int. 74 (2004) S63
67. Utting J.C., et al. Hypoxia inhibits the growth, differentiation and bone forming capacity of rat osteoblasts. Exp. Cell Res. 312 (2006) 1693-1702
68. Orr-Walker B.J., et al. Hormone replacement therapy causes a respiratory alkalosis in normal postmenopausal women. J. Clin. Endocrinol. Metab. 84 (1999) 1997-2001
69. White R.E. Estrogen and vascular function. Vasc. Pharmacol. 38 (2002) 73-80
70. Straub B., et al. Osteoporosis and mild metabolic acidosis in the rat after orchiectomy and their prevention: should prophylactic therapy be administered to patients with androgen deprivation?. J. Urol. 165 (2001) 1783-1789
71. Reid I.R., et al. Hydrochlorothiazide reduces loss of cortical bone in normal postmenopausal women: a randomized controlled trial. Am. J. Med. 109 (2000) 362-370
72. Schlienger R.G., et al. Use of β-blockers and risk of fractures. J. Am. Med. Assoc. 292 (2004) 1326-1332