MTOR kinase and the regulatory subunit of protein kinase A (PRKAR1A) Spatially and functionally interact during autophagosome maturation

Autophagy

Volumn 3, Issue 2, 2007, Pages 151-153

  Mavrakis, Manos ^a   Lippincott Schwartz, Jennifer ^a   Stratakis, Constantine A ^a   Bossis, Ioannis ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Autophagy; LC3; mTOR; PKA; RI

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MAMMALIAN TARGET OF RAPAMYCIN; RAB27A PROTEIN;

ARTICLE; AUTOPHAGY; BIOGENESIS; CARNEY COMPLEX; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOSOME; HELA CELL; HUMAN; HUMAN CELL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

MAMMALIA;

EID: 33947433238     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.3632     Document Type: Article

References (14)

1. Mavrakis M, Lippincott-Schwartz J, Stratakis CA, Bossis I. Depletion of type IA regulatory subunit (RIα) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency. Hum Mol Genet 2006; 15:2962-71.
2. Reimann EM, Brostrom CO, Corbin JD, King CA, Krebs EG. Separation of regulatory and catalytic subunits of the cyclic 3′,5′-adenosine monophosphate-dependent protein kinase(s) of rabbit skeletal muscle. Biochem Biophys Res Commun 1971; 42:187-94.
3. Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA. Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex. Nat Genet 2000; 26:89-92.
4. Stratakis CA. Mutations of the gene encoding the protein kinase A type I-α regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex). Ann NY Acad Sci 2002; 968:3-21.
5. Stroikin Y, Dalen H, Loof S, Terman A. Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material. Eur J Cell Biol 2004; 83:583-90.
6. Brunk UT, Terman A. Liporuscin: Mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 2002; 33:611-9.
7. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8.
8. Eskelinen EL. Maturation of autophagic vacuoles in mammalian cells. Autophagy 2005; 1:1-10.
9. Bampton ETW, Goemans CG, Niranjan D, Mizushima N, Tolkovsky AM. The dynamics of autophagy visualized in live cells. Autophagy 2005; 1:23-36.
10. Klionsky DJ. The molecular machinery of autophagy: Unanswered questions. J Cell Sci 2005; 118:7-18.
11. Jager S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P, Eskelinen EL. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci 2004; 117:4837-48.
12. Gutierrez MG, Munafo DB, Beron W, Colombo MI. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004; 117:2687-97.
13. Bucci C, Thomsen P, Nicoziani P, McCarthy J, van Deurs B. Rab7: A key to lysosome biogenesis. Mol Biol Cell 2000; 11:467-80.
14. Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, Lawrence Jr JC, Abraham RT. Phosphorylation of the translational repressor PHAS-1 by the mammalian target of rapamycin. Science 1997; 277:99-101.