Application of topical mitomycin C to the base of shave-removed keloid scars to prevent their recurrence

British Journal of Dermatology

Volumn 156, Issue 4, 2007, Pages 682-686

  Bailey, J N R ^a   Waite, A E ^a   Clayton, W J ^a   Rustin, M H A ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Collagen; Fibroblast; Keloid; Mitomycin C

Indexed keywords

MITOMYCIN C;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COURSE EVALUATION; DRUG EFFECT; FEMALE; HEMOSTASIS; HUMAN; KELOID; MALE; MEDICAL STAFF; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PATIENT SATISFACTION; PHOTOGRAPHY; PRIORITY JOURNAL; RATING SCALE; RECURRENT DISEASE; REPEATED DRUG DOSE; SCORING SYSTEM; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; WOUND INFECTION;

ADULT; FEMALE; GLYCOPEPTIDES; HUMANS; KELOID; MALE; MIDDLE AGED; MITOMYCIN; NUCLEIC ACID SYNTHESIS INHIBITORS; RECURRENCE; TREATMENT OUTCOME;

EID: 33947431078     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07714.x     Document Type: Article

References (30)

1. Fujiwara M, Muragaki Y, Ooshima A. Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix-metalloproteinase for migration. Br J Dermatol 2005; 153:295-300.
2. Bock O, Schmid-Ott G, Malewski P, Mrowietz U. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res 2006; 297:433-8.
3. Chowdri NA, Masarat M, Mattoo A, Darzi MA. Keloids and hypertrophic scars: results with intraoperative and serial postoperative corticosteroid injection therapy. Aust N Z J Surg 1999; 69:655-9.
4. Fikrle T, Pizinger K. Cryosurgery in the treatment of earlobe keloids: report of seven cases. Dermatol Surg 2005; 31:1728-31.
5. O'Brien L, Pandit A. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev 2006; 1:CD003826.
6. Maarouf M, Schleicher U, Schmachtenberg A, Ammon J. Radiotherapy in the management of keloids. Clinical experience with electron beam irradiation and comparison with X-ray therapy. Strahlenther Onkol 2002; 178:330-5.
7. Alster TS. Laser treatment of hypertrophic scars, keloids, and striae. Dermatol Clin 1997; 3:419-29.
8. Garg MK, Weiss P, Sharma AK et al. Adjuvant high dose rate brachytherapy (Ir-192) in the management of keloids which have recurred after surgical excision and external radiation. Radiother Oncol 2004; 73:233-6.
9. Saray Y, Gulec AT. Treatment of keloids and hypertrophic scars with Dermojet injections of bleomycin: a preliminary study. Int J Dermatol 2005; 44:777-84.
10. Espana A, Solano T, Quintanilla E. Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol Surg 2001; 27:23-7.
11. Kontochristopoulos G, Stefanaki C, Panagiotopoulos A et al. Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol 2002; 52:474-9.
12. Martin-Garcia RF, Busquets AC. Postsurgical use of imiquimod 5% cream in the prevention of earlobe keloid recurrences: results of an open-label, pilot study. Dermatol Surg 2005; 31:1394-8.
13. Stashower ME. Successful treatment of earlobe keloids with imiquimod after tangential shave excision. Dermatol Surg 2006; 32:380-6.
14. Berman B, Villa AM, Ramirez CC. Novel opportunities in the treatment and prevention of scarring. J Cutan Med Surg 2005; 8(Suppl. 3):32-6.
15. Al-Attar A, Mess S, Thomassen JM et al. Keloid pathogenesis and treatment. Plast Reconstr Surg 2006; 117:286-300.
16. Simman R, Alani H, Williams F. Effect of mitomycin C on keloid fibroblasts: an in vitro study. Ann Plast Surg 2003; 50:71-6.
17. Ribero F de AQ, Guaraldo L, Borges J de P et al. Clinical and histological healing of surgical wounds treated with mitomycin C. Laryngoscope 2004; 114:148-52.
18. Chen CW, Huang HT, Bair JS, Lee CC. Trabeculectomy with simultaneous topical application of mitomycin C in refractory glaucoma. J Ocul Pharmacol 1990; 6:175-82.
19. Seiler T, Schnelle B, Wollensak J. Pterygium excision using 193-nm excimer laser smoothing and topical mitomycin C. Ger J Ophthalmol 1992; 1:429-31.
20. Rodriguez JA, Ferrari C, Hernandez GA. Intraoperative application of topical mitomycin C 0.05% for pterygium surgery. Bol Asoc Med P R 2004; 96:100-2.
21. Rubinfeld RS, Pfister RR, Stein RM et al. Serious complications of topical mitomycin C after pterygium surgery. Ophthalmology 1992; 99:1647-54.
22. Eschle-Meniconi ME, Ahmad SR, Foster CS. Mucous membrane pemphigoid: an update. Curr Opin Ophthalmol 2005; 16:303-7.
23. Rahbar R, Jones DT, Nuss RC et al. The role of mitomycin in the prevention and treatment of scar formation in the pediatric aero-digestive tract: friend or foe? Arch Otolaryngol Head Neck Surg 2002; 128:401-6.
24. Perepelitsyn I, Shapshay SM. Endoscopic treatment of laryngeal and tracheal stenosis - has mitomycin C improved the outcome? Otolaryngol Head Neck Surg 2004; 131:16-20.
25. McLeod IK, Brooks DB, Mair EA. Revision choanal atresia repair. Int J Pediatr Otorhinolaryngol 2003; 67:517-24.
26. Roh J. Prevention of posterior glottic stenosis by mitomycin C. Ann Otol Rhinol Laryngol 2005; 114:558-62.
27. Ali I, Wojnarowska F, Wilkinson J. Topical Mitomycin C: an Effective Therapy for Laryngeal Mucous Membrane Pemphigoid. Case report, Dermatology Section, Royal Society of Medicine, 17 April 2003.
28. Hueman EM, Simpson CB. Airway complications from topical mitomycin C. Otolaryngol Head Neck Surg 2005; 133:831-5.
29. Talmi YP, Orenstein A, Wolf M, Kronenberg J. Use of mitomycin C for treatment of keloid: a preliminary report. Otolaryngol Head Neck Surg 2005; 132:598-601.
30. Sanders KW, Gage-White L, Stucker FJ. Topical mitomycin C in the prevention of keloid scar recurrence. Arch Facial Plast Surg 2005; 7:172-5.