Inhibition action of bufalin on human transplanted hepatocellular tumor and its effects on expressions of Bcl-2 and Bax proteins in nude mice

Journal of Chinese Integrative Medicine

Volumn 5, Issue 2, 2007, Pages 155-159

  Gu, Wei ^a   Han, Ke Qi ^a   Su, Yong Hua ^a   Huang, Xue Qiang ^a   Ling, Chang Quan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; Bcl 2; Bufalin; Liver neoplasms; Nude mice

Indexed keywords

BUFALIN; DOXORUBICIN; PROTEIN BAX; PROTEIN BCL 2; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; ELECTRON MICROSCOPY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LOW DRUG DOSE; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING; SURVIVAL RATE; SURVIVAL TIME; TISSUE STRUCTURE; TUMOR NECROSIS; TUMOR VOLUME; UPREGULATION;

EID: 33947423401     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20070211     Document Type: Article

References (14)

1. Yamado K, Hino K, Tomoyasu S. et al. Enhancement by bufalin of retinoic acid-induced differentiation of acute promyelocytic leukemia cells in primary culture. Leuk Res. 1998; 22(7): 589-595.
2. Yeh JY, Huang WJ, Kan SF, et al. Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells. Prostate. 2003; 54(2): 112-124.
3. Chen XY, Xu RC, Chen L, et al. Apoptosis of gastric cancer cells induced by bufalin. Ji Chu Yi Xue Yu Lin Chuang. 2000; 20(5): 50-53. Chinese with abstract in English.
4. Gu W, Han KQ, Su YH, et al. Effect of bufalin on proliferation of BEL-7402 human hepatocarcinoma cell line. Zhong Xi Yi Jie He Gan Bing Za Zhi. 2006; 16 (1): 16-17, 20. Chinese with abstract in English.
5. Gu W, Shen J, Zhai XF. Preliminary study on biological behavior and staging of transplanted hepatoma in rats. Zhong Xi Yi Jie He Xue Bao. 2005, 3(2): 136-138. Chinese with abstract in English.
6. Han KQ, Gu W, Zhang YN, et al. Establishment of orthotopic transplantation tumor models of human hepatocellular carcinoma in nude mice. Di Si Jun Yi Da Xue Xue Bao. 2004. 25(17): inside front cover. Chinese.
7. Li Q, Fan ZZ, Li XQ, et al. Effects of interventional therapy with norcantharidin microsphere on hepatoma in rats and its mechanism. Zhong Xi Yi Jie He Xue Bao. 2006; 4(4): 378-383. Chinese with abstract in English.
8. Chen Z, Zhai XF, Su YH, et al. Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer, Zhong Xi Yi Jie He Xue Bao. 2003; 1(3): 184-186. Chinese with abstract in English.
9. Kamano Y, Nogawa T, Yamashita A, et al. Isolation and structure of a 20, 21-epoxybufenolide series from "Ch'an Su". J Nat Prod. 2002; 65(7): 1001-1005.
10. Su YH, Niu X. Pharmacodynamic research of "Ch'an Su" praeparatum: a review. Beijing Zhong Yi Yao Da Xue Xue Bao. 2001; 24(2): 51-54. Chinese.
11. Su YH, Yin XC, Xie JM, et al. Inhibition effects of three kinds of bufotoxins on human SMMC-7721 and BEL-7402 hepatoma cell lines. Di Er Jun Yi Da Xue Xue Bao. 2003; 24(4): 393-395. Chinese with abstract in English.
12. Jiangsu New Medical College. Dictionary of Chinese Traditional Drugs. Shanghai: Shanghai Scientific and Technical Publishers. 1977: 84-85. Chinese.
13. Cory S, Adams JM. Killing cancer cells by flipping the Bcl-2/Bax switch. Cancer Cell. 2005; 8(1): 5-6.
14. Terada T, Nakanuma Y. Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigen (bcl-2, c-myc, Fas, Lewis(y) and p53) in human cholangiocarcinomas and hepatocellular carcinomas. Pathol Int. 1996; 46(10): 764-770.