Bovine hemoglobin (glutamer-250, Hemopure)-specific immunoglobulin G antibody cross-reacts with human hemoglobin but does not lyse red blood cells in vitro

Transfusion

Volumn 47, Issue 4, 2007, Pages 723-728

  Hamilton, Robert G ^a,b   Kickler, Thomas S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMER 250; HEMOGLOBIN; IMMUNOGLOBULIN G ANTIBODY; POLYMERIZED HEMOGLOBIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CLINICAL STUDY; COMPETITIVE INHIBITION; CONTROLLED STUDY; COW; CROSS REACTION; DRUG BINDING; DRUG DOSE ESCALATION; HEMOLYSIS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; IN VITRO STUDY; MAJOR CLINICAL STUDY; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; SINGLE DRUG DOSE;

ANIMALS; ANTIBODIES; CATTLE; CROSS REACTIONS; ERYTHROCYTES; HEMOGLOBINS; HEMOLYSIS; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN G;

EID: 33947420123     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2007.01176.x     Document Type: Article

References (18)

1. Greenberg AG, Kim HW. Hemoglobin-based oxygen carriers [review]. Crit Care 2004;8:S61-4.
2. Levy JH. The use of hemoglobin glutamer-250 (HBOC-201) as an oxygen bridge with acute anemia associated with surgical blood loss. Expert Opin Biol Ther 2003;3:509-17.
3. Levy JH, Goodnough LT, Greilich PE, et al. Polymerized bovine hemoglobin solution as a replacement for allogenic red blood cells transfusion after cardiac surgery: results of a randomized double blind trial. J Thorac Cardiovasc Surg 2002;124:35-42.
4. Sprung J, Kindscher JD, Wahr JA, et al. The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multi-center- randomized single-blinded trial. Anesth Analg 2002;94:799-808.
5. Pearce LB, Gawryl MS. The pharmacology of tissue oxygenation by Biopure's hemoglobin based oxygen carrier, Hemopure (HPOC-201). Adv Exp Med Biol 2003;530:261-70.
6. Hamilton RG, Kelly N, Gawryl MS, Rentko VT. Absence of immunopathology associated with repeated IV administration of bovine Hb-based oxygen carrier in dogs. Transfusion 2001;41:219-25.
7. Hamilton RG, Wisenauer JA, Golden DB, Valentine MD, Adkinson NF Jr. Selection of Hymenoptera venoms for immunotherapy based on patient's IgE antibody crossreactivity. J Allergy Clin Immunol 1993;92:651-9.
8. March SC, Parikh I, Cuatrecasas P. A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal Biochem 1974;60:149-52.
9. Hamilton RG, Kagey Sobotka A, Adkinson NF Jr. Solid phase radioimmunoassay for the quantitation of antigen-specific IgG using I-125 labeled protein A from Staphylococcal aureus. J Immunol 1979;122:1073-9.
10. Hamilton RG, Adkinson Jr. Naturally-occurring carbohydrate antibodies: interference in solid phase immunoassays. J Immunol Methods 1985;77:95-108.
11. Sauer-Eriksson AE, Kleywegt GJ, Uhlen M, Jones TA. Crystal structure of the c2 fragment of streptococcal Protein G in complex with the Fc domain of human IgG. Structure 1995;3:265-78.
12. Butler JE, Hamilton RG. Quantification of specific antibodies: methods of expression, standards, solid phase considerations and specific applications. In: Butler JE, editor. Immunochemistry of solid phase immunoassays. Boca Raton (FL): CRC Press; 1991. p. 173-98.
13. Petz LD, Garratt Y. Immune hemolytic anemias. 2nd ed. Philadelphia: Churchill Livingstone; 2004.
14. Arnoldo BD, Minei JP. Potential of hemoglobin-based oxygen carriers in trauma patients. Curr Opin Crit Care 2001;7:431-6.
15. Guan F, Uboh C, Soma L, Luo Y, Dressen B. Unique tryptic peptides specific for bovine and human hemoglobin in the detection and confirmation of hemoglobin-based oxygen carriers. Anal Chem 2004;76:5118-26.
16. Wahr JA, Anderson MM, Giacherio DA, et al. The effects of a blood-salvaging device on blood containing a hemoglobin based oxygen carrier, HBOC-201. J Cardiothorac Vasc Anesth 1997;11:10-2.
17. Agrawal YP, Freedman M, Szczepiorkowski ZM. Long-term transfusion of polymerized bovine hemoglobin in a Jehovah's Witness following chemotherapy for myeloid leukemia: a case report. Transfusion 2005;45:1735-8.
18. Gawryl MS, Hamilton RG. Immunologic safety studies of bovine derived human blood substitute (Hemopure). J Allergy Clin Immunol 2003;111(S166): Abstract 390.