Childhood-onset skin necrosis resulting from protein C deficiency [2]

Journal of the European Academy of Dermatology and Venereology

Volumn 21, Issue 4, 2007, Pages 537-539

  Criado, P R ^a   Bernardelli, I M ^a   Rivitti, E A ^a   Sotto, M N ^a   Vilella, M A C ^a   Valente, N Y S ^a   Martins, J E C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ENOXIHEPARIN; FRESH FROZEN PLASMA; HEPARIN DERIVATIVE; PROTEIN C; UNCLASSIFIED DRUG;

BLOOD ANALYSIS; CASE REPORT; CHILDHOOD DISEASE; ECCHYMOSIS; ERYTHEMA; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LETTER; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; RECURRENCE RISK; SCAR FORMATION; SKIN BIOPSY; SKIN NECROSIS; SKIN ULCER; WOUND HEALING;

EID: 33947416025     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2006.01937.x     Document Type: Letter

References (7)

1. Abu-Amero KK, Al-Hamed MH, Al-Batjniji FS. Homozygous protein C deficiency with purpura fulminans: Report of a new case and a description of a novel mutation. Blood Coagul Fibrinolysis 2003; 14: 303-306.
2. Kumagai K, Nishikawi K, Sato K et al. Perioperative management of a patient with purpura fulminans syndrome due to protein C deficiency. Can J Anesth 2001; 48: 1070-1074.
3. Loop M, Ferster A, Corazza F, Alhenc-Gelas M, Demulder A. Late onset of clinical symptoms and recurrent ecchymotic skin lesions in a 12-year-old girl with a severe double heterozygous protein C deficiency. J Pediatr Hematol Oncol 2004; 26: 2-4.
4. Steinkamp M, Geva A, Joffe S, Lapp CN, Neufeld EJ. Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C G1a Domain mutation, Arg 15Trp. J Pediatr Hematol Oncol 2002; 24: 685-688.
5. Auletta MJ, Headington JT. Purpura fulminans. A cutaneous manifestation of severe protein C deficiency. Arch Dermatol 1988; 124: 1387-1391.
6. Kemkes-Matthes B. Heterozygous protein C deficiency type I. Blut 1989; 58: 201-206.
7. Bernard GR, Vincent JL, Laterre PF et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.