Age- and gender-dependent association of the -344C/T polymorphism of CYP11B2 with blood pressure in European populations

Journal of Human Hypertension

Volumn 21, Issue 4, 2007, Pages 333-336

  Russo, P ^a   Loguercio, M ^a   Lauria, F ^a   Barba, G ^a   Arnout, J ^b   Cappuccio, F P ^c   Iacoviello, L ^d   Siani, A ^a  

^a CNR   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE SYNTHASE; CYTOSINE; THYMINE;

ADULT; AGE; ALLELE; ARTICLE; BELGIUM; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME POLYMORPHISM; ETHNICITY; EUROPE; FEMALE; GENDER; HUMAN; HYPERTENSION; ITALY; MALE; PHENOTYPE; PREVALENCE; PROMOTER REGION; SAMPLE SIZE; UNITED KINGDOM;

ADULT; AGE FACTORS; ALDOSTERONE SYNTHASE; ANALYSIS OF VARIANCE; BLOOD PRESSURE; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEX FACTORS;

EID: 33947409039     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/sj.jhh.1002136     Document Type: Article

References (12)

1. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S, Ulick S et al. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992; 355: 262-265.
2. Davies E, Kenyon CJ. CYP11B2 polymorphisms and cardiovascular risk factors. J Hypertens 2003; 21: 1249-1253.
3. Connell JM, Fraser R, MacKenzie SM, Friel EC, Ingram MC, Holloway CD et al. The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Mol Cell Endocrinol 2004; 217: 243-247.
4. Kumar NN, Benjafield AV, Lin RC, Wang WY, Slowasser M, Morris BJ. Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension. J Hypertens 2003; 21: 1331-1337.
5. Barbato A, Russo P, Siani A, Folkerd EJ, Miller MA, Venezia A et al. Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population. J Hypertens 2004; 22: 1895-1901.
6. Russo P, Siani A, Venezia A, Iacone R, Russo O, Barba G et al. Interaction between the C(-344)T polymorphism of CYP11B2 and age in the regulation of blood pressure and plasma aldosterone levels: cross-sectional and longitudinal findings of the Olivetti Prospective Heart Study. J Hypertens 2002; 20: 1785-1792.
7. Sarzani R, Salvi F, Dessi-Fulgheri P, Catalini R, Mazzara D, Cola G et al. Aldosterone synthase alleles and cardiovascular phenotype in young adults. J Hum Hypertens 2003; 17: 859-864.
8. Casiglia E, Tikhonoff V, Mazza A, Rynkiewicz A, Limon J, Caffi S et al. C-344T polymorphism of the aldosterone synthase gene and blood pressure in the elderly: A population-based study. J Hypertens 2005; 23: 1991-1996.
9. Iacoviello L, Arnout J, Buntinx F, Cappuccio FP, Dagnelie PC, de Lorgeril M, et al., for the European Collaborative Group of the IMMIDIET Project. Dietary habit profile in European communities with different risk of myocardial infarction: The impact of migration as a model of gene-environment interaction - the IMMIDIET study. Nutr Metab Cardiovasc Dis 2001; 11: 122-126.
10. Whitworth JA, World Health Organization, International Society of Hypertension Writing Group. 2003 World Health Organization (WHO)/ International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 2003; 21: 1983-1992.
11. Kupari M, Hautanen A, Lankinen L, Koskinen P, Virolainen J, Nikkila H et al. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Circulation 1998; 97: 569-575.
12. Ylitalo A, Airaksinen KE, Hautanen A, Kupari M, Carson M, Virolainen J et al. Baroflex sensitivity and variants of the renin angiotensin system genes. J Am Coll Cardiol 2000; 35: 194-200.