Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: Effect of vitamin D and calcium citrate therapy

Endocrine Practice

Volumn 12, Issue 5, 2006, Pages 559-567

  Taylor, Harris C ^a,b   Elbadawy, Emad H ^a  

^a FAIRVIEW HOSPITAL   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CALCIUM CITRATE PLUS CHOLECALCIFEROL; CITRATE CALCIUM; COLECALCIFEROL; ERGOCALCIFEROL; MAGNESIUM OXIDE; PHENYTOIN; POTASSIUM CHLORIDE; THEOPHYLLINE; UNCLASSIFIED DRUG; BICARBONATE; CALCIUM; VITAMIN D;

ADULT; ANAMNESIS; ARTICLE; BONE BIOPSY; BONE DENSITY; CALCIUM DEFICIENCY; CASE REPORT; CLINICAL FEATURE; DRUG DOSE REDUCTION; FANCONI RENOTUBULAR SYNDROME; FEMALE; HUMAN; HUMAN TISSUE; HYPERALDOSTERONISM; KIDNEY TUBULE ACIDOSIS; LABORATORY TEST; OSTEOMALACIA; OSTEOPOROSIS; TREATMENT OUTCOME; VITAMIN D DEFICIENCY; BLOOD; BONE; CYTOLOGY; EVALUATION; PATHOLOGY; URINE;

ACIDOSIS, RENAL TUBULAR; ADULT; BICARBONATES; BONE AND BONES; CALCIUM; CALCIUM CITRATE; FANCONI SYNDROME; FEMALE; HUMANS; HYPERALDOSTERONISM; OSTEOMALACIA; OSTEOPOROSIS; TREATMENT OUTCOME; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 33947400676     PISSN: 1530891X     EISSN: None     Source Type: Journal    
DOI: 10.4158/EP.12.5.559     Document Type: Article

References (33)

1. Dubose TD Jr. Acid-base disorders. In: Brenner BM, ed. Brenner and Rector's The Kidney. 7th ed. Philadelphia, PA: WB Saunders, 2004: 921-996.
2. Burgess N, Osman AA. Acidosis in relation to acute rickets. Lancet. 1924;1:281.
3. Guignard JP, Torrado A. Proximal renal tubular acidosis in vitamin D deficiency rickets. Acta Paediatr Scand. 1973;62:543-546.
4. Salassa RM, Power MH, Ulrich JA, Hayles AB. Observations on the metabolic effects of vitamin D in Fanconi's syndrome. Mayo Clin Proc. 1954;29:214-224.
5. Huguenin M, Schacht R, David R. Infantile rickets with severe proximal renal tubular acidosis, responsive to vitamin D. Arch Dis Child. 1974;49:955-959.
6. Sockalosky JJ, Ulstrom RA, DeLuca HF, Brown DM. Vitamin D-resistant rickets: end-organ unresponsiveness to 1,25(OH)2D3. J Pediatr. 1980;96:701-703.
7. Vainsel M, Manderlier T, Vis HL. Proximal renal tubular acidosis in vitamin D deficiency rickets. Biomedicine. 1974;22:35-40.
8. Muldowney FP, Freaney R, McGeeney D. Renal tubular acidosis and amino-aciduria of dietary or intestinal origin. Q J Med. 1968;37:517-539.
9. Scott J, Elias E, Moult PJ, Barnes S, Wills MR. Rickets in adult cystic fibrosis with myopathy, pancreatic insufficiency and proximal tubular dysfunction. Am J Med. 1997; 63:488-492.
10. Ahmed A, Sims RV. Proximal renal tubular acidosis associated with osteomalacia. South Med J. 2001;94:536-539.
11. Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338:777-783.
12. Gloth FM III, Gundberg CM, Hollis BW, Haddad JG Jr, Tobin JD. Vitamin D deficiency in homebound elderly persons. JAMA. 1995;274:1683-1686.
13. Jacques PF, Felson DT, Tucker KL, et al. Plasma 25 hydroxyvitamin D and its determinants in an elderly population sample. Am J Clin Nutr. 1997;66:929-936.
14. Van der Wielen RP, Lowik MR, Van den Berg H, et al. Serum vitamin D concentrations among elderly people in Europe. Lancet. 1995;346:207-210.
15. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004;291:1999-2006.
16. Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Körfer R, Stehle P. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol. 2003;41:105-112.
17. Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey. 1988-1994. Am J Clin Nutr. 2002;76:187-192.
18. Zhou XJ, Vaziri ND, Segal JL, Winer RL, Eltorai I, Brunnemann SR. Effects on chronic spinal cord injury and pressure ulcer on 25(OH)-vitamin D levels. J Am Paraplegia Soc. 1992;16:9-13.
19. Bauman WA, Zhong YG, Schwartz E. Vitamin D deficiency in veterans with chronic spinal cord injury. Metabolism. 1995;44:1612-1616.
20. Wrong O, Davies HE. The excretion of acid in renal disease. Q J Med. 1959;28:259-313.
21. Sebastian A, McSherry E, Morris RC Jr. On the mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (type 2 RTA). J Clin Invest. 1971;50:231-243.
22. Brenes LG, Sanchez MI. Impaired urinary ammonium excretion in patients with isolated proximal renal tubular acidosis. J Am Soc Nephrol. 1993;4:1073-1078.
23. Bergeron M, Gougoux A, Noël J, Parent L. The renal Fanconi syndrome. In: Scriver CR, Beudet AL, Sly WS, Valle D, Vogelstein B, Childs B, eds. The Metabolic and Molecular Bases of Inherited Disease. 8th ed. New York, NY: McGraw-Hill, 2001: 5023-5038.
24. Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA. Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features. Clin Endocrinol (Oxf). 1995;43:479-490.
25. Pedrera JD, Canal ML, Carvajal J, et al. Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy. Eur J Clin Invest. 2000;30:895-899.
26. Weinstein RS, Bryce GF, Sappington LJ, King DW, Gallagher BB. Decreased serum ionized calcium and normal vitamin D metabolite levels with anticonvulsant drug treatment. J Clin Endocrinol Metab. 1984;58:1003-1009.
27. Mosekilde L, Melsen F. Dynamic differences in trabecular bone remodeling between patients after jejunoileal bypass for obesity and epileptic patients receiving anticonvulsant therapy. Metab Bone Dis Rel Res. 1980;2:77-82.
28. Parfitt AM, Rao DS, Stanciu J, Villanueva AR, Kleerekoper M, Frame B. Irreversible bone loss in osteomalacia: comparison of radial photon absorptiometry with iliac bone histomorphometry during treatment. J Clin Invest. 1985;76:2403-2412.
29. Levis S, Gomez A, Jimenez C, et al. Vitamin D deficiency and seasonal variation in an adult south Florida population. J Clin Endocrinol Metab. 2005;90:1557-1562.
30. Hewison M, Zehnder D, Chakraverty R, Adams JS. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol. 2004;215:31-38.
31. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-1503.
32. Casteels K, Waer M, Bouillon R, et al. 1,25-Dihydroxyvitamin D3 restores sensitivity to cyclophosphamide-induced apoptosis in non-obese diabetic (NOD) mice and protects against diabetes. Clin Exp Immunol. 1998;112:181-187.
33. Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R. Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia. 1994;37:552-558.