T-cell epitope mapping of ORF2 and ORF3 proteins of human hepatitis e virus

Journal of Viral Hepatitis

Volumn 14, Issue 4, 2007, Pages 283-292

  Aggarwal, R ^a,e   Shukla, R ^a   Jameel, S ^b   Agrawal, S ^a   Puri, P ^c   Gupta, V K ^c   Patil, A P ^d   Naik, S ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c Department of Laboratory Medicine and Transfusion Medicine   (India)

^d ARMY HOSPITAL   (India)

^e ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Cellular immune response; Immunopathogenesis; Lymphocyte proliferation assay; Lymphocytes; Peripheral blood mononuclear cells; Vaccination

Indexed keywords

AMINO ACID; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; OPEN READING FRAME 2 PROTEIN; OPEN READING FRAME 3 PROTEIN; PEPTIDE LIBRARY; PROTEIN DERIVATIVE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADULT; AGED; ALLELE; AMINO ACID SEQUENCE; ARTICLE; CD4+ T LYMPHOCYTE; CELL ASSAY; CELL PROLIFERATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; HEPATITIS E; HEPATITIS E VIRUS; HUMAN; IMMUNOPATHOGENESIS; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; FEMALE; HEPATITIS E; HEPATITIS E VIRUS; HLA ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; VIRAL PROTEINS;

EID: 33947395722     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2006.00796.x     Document Type: Article

References (35)

1. Aggarwal R, Krawczynski K. Hepatitis E: an overview and recent advances in clinical and laboratory research. J Gastroenterol Hepatol 2000; 15: 9-20.
2. Krawczynski K, Aggarwal R. Hepatitis E. In: Schiff ER, Sorrell MF, Maddrey WC, eds. Schiff's Diseases of the Liver, 9th edn. Philadelphia, PA: Lippincott-Raven, 2002: 877-889.
3. Naik SR, Aggarwal R, Salunke PN, Mehrotra NN. A large waterborne viral hepatitis E epidemic in Kanpur, India. Bull World Health Organ 1992; 70: 597-604.
4. Aggarwal R, Naik SR. Hepatitis E: intrafamilial transmission versus waterborne spread. J Hepatol 1994; 22: 718-723.
5. Somani SK, Aggarwal R, Naik SR, Srivastava S, Naik S. A serological study of intra-familial spread from patients with sporadic hepatitis E virus infection. J Viral Hepat 2003; 10: 446-449.
6. Tam AW, Smith MM, Guerra ME et al. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 1991; 185: 120-131.
7. Zafrullah M, Ozdener MH, Panda SK, Jameel S. The ORF3 protein of hepatitis E virus is a phosphoprotein that associates with the cytoskeleton. J Virol 1997; 71: 9045-9053.
8. Tyagi S, Korkaya H, Zafrullah M, Jameel S, Lal SK. The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2. J Biol Chem 2002; 277: 22759-22767.
9. Korkaya H, Jameel S, Gupta D et al. The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. J Biol Chem 2001; 276: 42389-42400.
10. Favorov MO, Fields HA, Purdy MA et al. Serologic identification of hepatitis E virus infections in epidemic and endemic settings. J Med Virol 1992; 36: 246-250.
11. Khudyakov YE, Khudyakova NS, Fields HA et al. Epitope mapping in proteins of hepatitis E virus. Virology 1993; 194: 89-96.
12. Khudyakov YE, Lopareva EN, Jue DL, Crews TK, Thyagarajan SP, Fields HA. Antigenic domains of the open reading frame 2-encoded protein of hepatitis E virus. J Clin Microbiol 1999; 37: 2863-2871.
13. Riddell MA, Li F, Anderson DA. Identification of immunodominant and conformational epitopes in the capsid protein of hepatitis E virus by using monoclonal antibodies. J Virol 2000; 74: 8011-8017.
14. Dawson GJ, Chau KH, Cabal CM, Yarbough PO, Reyes GR, Mushahwar IK. Solid-phase enzyme-linked immunosorbent assay for hepatitis E virus IgG and IgM antibodies utilizing recombinant antigens and synthetic peptides. J Virol Methods 1992; 38: 175-186.
15. Coursaget P, Buisson Y, Depril N et al. Mapping of linear B cell epitopes on open reading frame 2- and 3-encoded proteins of hepatitis E virus using synthetic peptides. FEMS Microbiol Lett 1993; 109: 251-255.
16. Kaur M, Hyams KC, Purdy MA et al. Human linear B-cell epitopes encoded by the hepatitis E virus include determinants in the RNA-dependent RNA polymerase. Proc Natl Acad Sci USA 1992; 89: 3855-3858.
17. Khuroo MS, Kamili S, Dar MY, Moecklii R, Jameel S. Hepatitis E and long-term antibody status. Lancet 1993; 341: 1355-1355.
18. Tsarev SA, Tsareva TS, Emerson SU et al. Recombinant vaccine against hepatitis E: dose response and protection against heterologous challenge. Vaccine 1997; 15: 1834-1838.
19. Purdy MA, McCaustland KA, Krawczynski K, Spelbring J, Reyes GR, Bradley DW. Preliminary evidence that a trpE-HEV fusion protein protects cynomolgus macaques against challenge with wild-type hepatitis E virus (HEV). J Med Virol 1993; 41: 90-94.
20. Zhang M, Emerson SU, Nguyen H et al. Recombinant vaccine against hepatitis E: duration of protective immunity in rhesus macaques. Vaccine 2002; 20: 3285-3291.
21. Naik S, Aggarwal R, Naik SR et al. Evidence for activation of cellular immune responses in patients with acute hepatitis E. Indian J Gastroenterol 2002; 21: 149-152.
22. Pal R, Aggarwal R, Naik SR, Das V, Das S, Naik SR. Immunological alterations in pregnant women with acute hepatitis E. J Gastroenterol Hepatol 2005; 20: 1094-1101.
23. Ferrari C, Missale G, Boni C, Urbani S. Immunopathogenesis of hepatitis B. J Hepatol 2003; 39(Suppl. 1): S36-S42.
24. Zafrullah M, Khursheed Z, Yadav S, Sehgal D, Jameel S, Ahmad F. Acid pH enhances structure and structural stability of the capsid protein of hepatitis E virus. Biochem Biophys Res Commun 2003; 313: 67-73.
25. Fernandez-Botran R, Vetvicka V. Methods in Cellular Immunology, 2nd edn. Boca Raton, FL: CRC Press, 2002: 53-57.
26. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16: 1215-1218.
27. Coursaget P, Depril N, Buisson Y, Molinie C, Roue R. Hepatitis type E in a French population: detection of anti-HEV by a synthetic peptide-based enzyme-linked immunosorbent assay. Res Virol 1994; 145: 51-57.
28. Zhang M, Emerson SU, Nguyen H et al. Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells. Vaccine 2001; 20: 853-857.
29. Purcell RH, Nguyen H, Shapiro M et al. Pre-clinical immunogenicity and efficacy trial of a recombinant hepatitis E vaccine. Vaccine 2003; 21: 2607-2615.
30. Li TC, Yamakawa Y, Suzuki K et al. Expression and self-assembly of empty virus-like particles of hepatitis E virus. J Virol 1997; 71: 7207-7213.
31. Kamili S, Spelbring J, Carson D, Krawczynski K. Protective efficacy of hepatitis E virus DNA vaccine administered by gene gun in the cynomolgus macaque model of infection. J Infect Dis 2004; 189: 258-264.
32. He J, Hayes CG, Binn LN et al. Hepatitis E virus DNA vaccine elicits immunologic memory in mice. J Biomed Sci 2001; 8: 223-226.
33. Zhou Y-H, Purcell RH, Emerson SU. An ELISA for putative neutralizing antibodies to hepatitis E virus detects antibodies to genotypes 1, 2, 3 and 4. Vaccine 2004; 22: 2578-2585.
34. Jung MC, Pape GR. Immunology of hepatitis B infection. Lancet Infect Dis 2002; 2: 43-50.
35. Rosen HR. Hepatitis C pathogenesis: mechanisms of viral clearance and liver injury. Liver Transpl 2003; 9: S35-S43.