HIV-1 viremia during the first 28 weeks of pregnancy is not associated with mother-to-child transmission

Brazilian Journal of Infectious Diseases

Volumn 10, Issue 4, 2006, Pages 259-263

  Senise, Jorge F ^a,b,c   Palacios, R ^a,b   Tanno, Z N ^a   Lunardi, L ^a,b   Waghabi, G R ^a   Vaz, M J R ^a   Diaz, R S ^a   Castelo, A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL IPIRANGA   (Brazil)

^c NONE   (Brazil)

Author keywords

Antiretroviral therapy; Disease transmission; High active Brazil; HIV 1; Vertical transmission; Viral load

Indexed keywords

DIDANOSINE; INDINAVIR; LAMIVUDINE; LOPINAVIR; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; STAVUDINE; ZIDOVUDINE;

ADOLESCENT; ADULT; ARTICLE; BRAZIL; BREAST FEEDING; COMPUTER ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR CLINICAL STUDY; MEDICAL RECORD; MONOTHERAPY; PREGNANCY; PREGNANT WOMAN; PRENATAL CARE; PRENATAL EXPOSURE; PRENATAL PERIOD; VERTICAL TRANSMISSION; VIREMIA; VIRUS LOAD;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DISEASE TRANSMISSION, VERTICAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT, NEWBORN; MIDDLE AGED; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY TRIMESTER, SECOND; RETROSPECTIVE STUDIES; VIRAL LOAD;

EID: 33947374737     PISSN: 14138670     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1413-86702006000400009     Document Type: Article

References (25)

1. UNAIDS/WHO. AIDS epidemic update: 2004. UNAIDS/WHO [Available online from http://www.unaids.org/wad2004/EPIupdate2004_html_en/epi04_00_en.htm Accessed on Dec 2, 2004].
2. Anonymous. Casos de AIDS (números e percentual) em indivíduos com 13 anos de idade ou mais, segundo categoria de exposição hierarquizada por sexo e ano de diagnóstico. Brasil, 1980-2004. Bol Epidemiol AIDS 2004;18:26.
3. Szwarcwald C., Carvalho M.F. Estimativa do Número de Indivíduos de 15 a 49 anos Infectados pelo HIV, Brasil, 2000. Bol Epidemiol AIDS 2001;14:35-40.
4. Mock P.A., Shaffer N., Bhadrakom C., et al. Maternal viral load and timing of mother-to-child HIV transmission, Bangkok, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group. AIDS 1999;13:407-14.
5. Dunn D.T., Newell M.L., Ades A.E., Peckham C.S. Risk of human immunodeficiency virus type 1 transmission through breastfeeding. Lancet 1992;340:585-8.
6. Nieburg P., Hu D.J., Moses S., Nagelkerke N. Contribution of breastfeeding to the reported variation in rates of mother-to-child HIV transmission. AIDS 1995;9:396-7.
7. Landesman S.H., Kalish L.A., Burns D.N., et al. Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. The Women and Infants Transmission Study. N Engl J Med 1996;334:1617-23.
8. Anonymous. Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial. The European Mode of Delivery Collaboration. Lancet 1999;353:1035-9.
9. Mofenson L.M., Lambert J.S., Stiehm E.R., et al. Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team. N Engl J Med 1999;341:385-93.
10. Anonymous. The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1 - a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group. N Engl J Med 1999;340:977-87.
11. Garcia P.M., Kalish L.A., Pitt J., et al. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N Engl J Med 1999;341:394-402.
12. Magder L.S., Mofenson L., Paul M.E., et al. Risk Factors for In Utero and Intrapartum Transmission of HIV. J Acquir Immune Defic Syndr 2005;38:87-95.
13. Lallemant M., Jourdain G., Le Coeur S., et al. A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med 2000;343:982-91.
14. Anonymous. Recomendações para profilaxia da transmissão vertical do HIV e terapia antiretroviral em gestantes - 2004. Ministério da Saúde do Brasil, Secretaria de Vigilância em Saúde, Programa Nacional de DST/AIDS [Available online from http://www.aids.gov.br/final/biblioteca/ gestante_2004/ConsensoGestante2004.doc Accessed on Jan 21, 2005].
15. Anonymous. Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States - December 17, 2004. U.S. Department of Health and Human Services [Available online from http://www.aidsinfo.nih.gov/guidelines/ perinatal/PER_121704.pdf Accessed on Jan 20, 2005].
16. Shapiro D.E., Sperling R.S., Coombs R.W. Effect of zidovudine on perinatal HIV-1 transmission and maternal viral load. Pediatric AIDS Clinical Trials Group 076 Study Group. Lancet 1999;354:156.
17. Shaffer N., Chuachoowong R., Mock P.A., et al. Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Bangkok Collaborative Perinatal HIV Transmission Study Group. Lancet 1999;353:773-80.
18. Souza I.E.A.M., Machado D.M., Succi R.C., Diaz R.S. RNA Viral Load Test for early diagnosis of Vertical Transmission of HIV-1 Infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 2000;23:358-60.
19. Succi R.C.M., B.S.G, Brazilian Pediatric Society Study Group for MCT of HIV. Brazilian multicentric collaborative study develop to determine the rate of Mother to Child Transmission (MCT) of HIV in Brazil [Abstract B11560]. XV International AIDS Conference. Bangkok 2004.
20. Van der Ende M., Tempelman C., Timmermans S., et al. Tolerance, Safety, and Efficacy of Highly Active Antiretroviral Therapy in HIV-infected Pregnant Women in the Netherlands from January 1997 to June 2003 [Poster Abstract 920]. 11th Conference on Retroviruses and Opportunistic Infections. San Francisco 2004.
21. Connor E.M., Sperling R.S., Gelber R., et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 1994;331:1173-80.
22. Poirier M.C., Olivero O.A., Walker D.M., Walker V.E. Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs. Toxicol Appl Pharmacol 2004;199:151-61.
23. Cooper E.R., Charurat M., Mofenson L., et al. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr 2002;29:484-94.
24. Anonymous. Combination antiretroviral therapy and duration of pregnancy. Aids. Vol 14, 2000:2913-20.
25. Shapiro D., Tuomala R., Pollack H., et al. Mother-to-Child HIV Transmission Risk According to Antiretroviral Therapy, Mode of Delivery, and Viral Load in 2895 U.S. Women (PACTG 367) [Oral abstract 99]. 11th Conference on Retroviruses and Opportunistic Infections. San Francisco 2004.