Comparison of amikacin concentrations in normal and inflamed joints of horses following intra-articular administration

Handbook of Environmental Chemistry, Volume 5: Water Pollution

Volumn 38, Issue 2, 2006, Pages 189-191

  Taintor, J ^a   Schumacher, J ^a   DeGraves, F ^b  

^a AUBURN UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Amikacin; Concentration; Horse; Intra articular; Joints

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

EID: 33947324682     PISSN: 14336863     EISSN: 04251644     Source Type: Book Series    
DOI: None     Document Type: Article

References (16)

1. Anon (1989) SAS/STAT User's Guide, 4th edn., SAS Institute Inc., Cary, North Carolina. p 849.
2. Adamson, P.J.W., Wilson, W.D., Hirsh, D.C., Baggot, J.D. and Martin, L.D. (1985) Susceptibility of equine bacterial isolates to antimicrobial agents. Am. J. vet. Res. 46, 447-450.
3. Dowling, P.M. (2004) Antimicrobial therapy. In: Equine Clinical Pharmacology, Eds: A.L. Bertone and L.J.I. Horspool, W.B. Saunders Co., Philadelphia. pp 13-48.
4. Errecalde, J.O., Carmely, D., Marino, E.L. and Mestorino, N. (2001) Pharmacokinetics of amoxycillin in normal horses and horses with experimental arthritis. J. vet. Pharmacol. Therap. 24, 1-6.
5. Firth, E.C., Klein, W.R., Nouws, J.F.M. and Wensing, T. (1988) Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies. J. vet. Pharmacol. Therap. 11, 56-62.
6. Kashuba, A.D.M., Nafizer, A.N., Drusano, G.L. and Bertino, J.S. (1999) Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria. Antimicrob. Agents Chemother. 43, 623-629.
7. Lloyd, K.C., Stover, S.M., Pascoe, J.R. and Adams, P. (1990) Synovial fluid pH, cytologic characteristics, and gentamicin concentration after intra-articular administration of the drug in an experimental model of infectious arthritis in horses. Am. J. vet. Res. 51, 1363-1369.
8. McIlwraith, C.W. (1983) Treatment of septic arthritis. Vet. Clin. N. Am.: Equine Pract. 5, 363-379.
9. Orsini, J.A., Soma, L.R., Rourke, J.E. and Park, M. (1985) Pharmacokinetics of amikacin in the horse following intravenous and intramuscular administration. J. vet. Pharmacol. Ther. 8, 194-201.
10. Sedrish, S.A., Moore, R.M. and Barker, S.A. (1994) Pharmacokinetics of single dose intra-articular administratin of amikacin in the radiocarpal joints of normal horses. In: Proceedings of the American College of Veterinary Surgeons Meeting, Chicago, Illinois. p 437.
11. Shargel, L. and Yu, A.B.C. (1992) Physiologic pharmacokinetic models In: Applied Biopharmaceutics and Pharmacokinetics, Appleton and Lange, Norwalk. p 625.
12. Stover, S.M. and Pool, R. (1985) Effect of intra-articular gentamicin sulfate on normal equine synovial membrane. Am. J. vet. Res. 46, 2485-2491.
13. Tulamo, R.M., Bramlage, L.R. and Gabel, A.A. (1989) Sequential clinical and synovial fluid changes associated with acute infectious arthritis in the horse. Equine vet. J. 21, 325-331.
14. Van Pelt, R. (1974) Interpretation of synovial fluid findings in the horse. J. Am. vet. med. Ass. 165, 91-95.
15. Wright, I.M., Dyson, S.J., Kannegieter, N., MacGregor, C.M., Parks, A.H. and Phillips, T.J. (1995) The locomotor system. In: The Equine Manual, Eds: A.J. Higgins and I.M. Wright, W.B. Saunders Co., Philadephia. pp 797-919.
16. Yarbrough, T. (2004) Intrarticular medication. In: Equine Clinical Pharmacology, Eds: A.L. Bertone and L.J.I. Horspool, W.B. Saunders Co., Philadephia. pp 121-134.