Evaluation of phenytoin pharmacokinetics in neurotrauma patients

Daru

Volumn 15, Issue 1, 2007, Pages 34-40

  Shohrati, M ^a   Rouini, M R ^b   Mojtahedzadeh, M ^b   Firouzabadi, M ^a  

^a Baqiatallah University of Medical Sciences   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Free fraction; Neurotrauma; Pharmacokinetic; Phenytoin

Indexed keywords

PHENYTOIN;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MALE; NERVOUS SYSTEM INJURY;

EID: 33947322056     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Annegers JF, Grabow JD. Seizures after head trauma. J Neurology 1980; 30: 683-689
2. Bauer LA, Edwards WAD, Dellinger EP. Importance of unbound phenytoin serum levels in head trauma patients. J Trauma; 1983; 23: 1058-1060
3. Dippiro. Text book of pharmacotherapy, Chapter 57
4. McKindley DS, Boucher BA, Hess MM. Effect of acute phase response on phenytoin metabolism in neurotrauma patients. J Clin Pharmacol 1997;37: 129-139.
5. Temkin NR, Dikmen SS, Wilnesky AJ. A randomized, double- blind study of phenytoin for prevention of post- traumatic seizures. N Eng J Med 1990;323: 497-502.
6. Young B, Rapp RP, Norton JA, Haack D, Tibbs PA, Bean JR. Failure of prophylactically administered phenytoin to prevent late post-traumatic seizures. J Neurosurg 1983; 58: 236-241.
7. Lee ST, Lui TN. Early seizure after mild closed head injury. J Neurosury 1992;76: 435
8. Gottlieb ME, Sarfeh J, Stratton H. Hepatic perfusion and splanchnic oxygen consumption in patients post injury. J .Trauma 1983;28;836-43
9. Boucher BA, Kuhl DA, Fabian TC, Robertson JT. Effect of neurotrauma on hepatic drug clearance. Clin Pharmacol Ther 1991; 50: 487-97.
10. Boucher BA, Rodman JH, Jaresko GS, Rasmussen SN, Watridge CB, Fabian TC. Phenytoin pharmacokinetics in critically ill trauma patients. Clin Pharmacol Ther 1988; 44:675-83.
11. Boucher BA, Rodman JH , Fabian TC, Cupit GC, Ludden TM, West ME. Disposition of phenytoin in critically ill trauma patients. Clin Pharm; 1987; 6: 881-887.
12. Markowsky SJ, Skaar D, Christie JM, Eyer ST, Ehresman DJ. Phenytoin protein binding and dosage requirement during acute and convalescent phases following brain injury. Ann Pharmacother 1996;30:443-448.
13. Michael J, Maozhi L. Simultaneous rapid high performance liquid chromatographic determination of phenytoin and its products fosphenytoin in human plasma and ultrafiltrate. J of Chromato B 1997; 693: 407-414
14. Grasela T.H, Sheiner LB, Rambeck. Steady state pharmacokinetics of phenytoin from routinely collected patients data. Clinical pharmacokinetics 1983; 8: 355-364
15. Vozeh S. Predicting individual phenytoin dosage. J Pharmacokinetic Biopharm 1981; 9:131-46
16. Lambie DG. Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. Lancet 1976;2:386-89
17. Maver GE, Mullen PW. Phenytoin dose adjustment in epileptic patients. British Journal of clinical pharmacology 1974; 1:163-168
18. Neeta, P. Richard J. Pharmacokinetic of phenytoin in children with acute neurotrauma. Critical Care Medicine; 1995, vol 23, No5
19. Obrist WD, Lang fitt TN. cerebral blood flow and metabolism in comatose patients with acute head injury. J Neurosurg 1984; 61: 241-253
20. Zielman S, Mielck F. A rational basis for the measurement of free phenytoin concentration in critically ill trauma patients. Threa Drug Moni 1994;19:139-44
21. Driscoll DE, McMabon. Phenytoin toxicity in a critically ill, hypoalbuminemic patients with normal serum drug concentration. Crit Care Med 1988; 16, 1248
22. Applied pharmacokinetics, principles of therapeutic drug monitoring. Third ed. 1992 Appliedd Therapeutic Inc.USA.