Metabolic syndrome and erectile dysfunction. Epidemiologic associations and pathogenetic links;Metabolisches syndrom und erektile dysfunktion. Epidemiologische und pathogenetische zusammenhänge

Urologe - Ausgabe A

Volumn 46, Issue 3, 2007, Pages 287-292

  Wirth, A ^a   Manning, M ^b   Buttner H ^b  

^a Teutoburger Wald Klinik   (Germany)

^b LILLY DEUTSCHLAND GMBH   (Germany)

Author keywords

Cardiovascular disease; Diabetes mellitus; Endothelial dysfunction; Erectile dysfunction; Metabolic syndrome

Indexed keywords

NITRIC OXIDE;

ATHEROSCLEROSIS; CARDIOVASCULAR RISK; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; METABOLIC SYNDROME X; OBESITY; PATHOGENESIS; PERIPHERAL VASCULAR DISEASE; PHENOTYPE; PREVALENCE; REVIEW; RISK FACTOR;

ATHEROSCLEROSIS; COMORBIDITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMPOTENCE; MALE; METABOLIC SYNDROME X; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; STATISTICS;

EID: 33947322030     PISSN: 03402592     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00120-006-1244-y     Document Type: Review

References (40)

1. Bacon CG, Mittleman MA, Kawachi I et al. (2003) Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 139: 161-168
2. Billups KL (2005) Erectile dysfunction as a marker for vascular disease. Curr Urol Rep 6: 439-444
3. Bivalacqua TJ, Usta MF, Champion HC et al. (2003) Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. J Androl 24 [6 Suppl]: 17-37
4. Blanker MH, Bohnen AM, Groeneveld FP et al. (2001) Correlates for erectile and ejaculatory dysfunction in older Dutch men: a community-based study. J Am Geriatr Soc 49: 436-442
5. Braun M, Wassmer G, Klotz T et al. (2000) Epidemiology of erectile dysfunction: results of the 'Cologne Male Survey'. Int J Impot Res 12: 305-311
6. Burnett AL (2005) Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: association and management. Curr Urol Rep 6: 470-475
7. Charakida M, Deanfield JE, Halcox JP (2005) The role of nitric oxide in early atherosclerosis. Eur J Clin Pharmacol 62 [Suppl 13]: 69-78
8. Chung WS, Sohn JH, Park YY (1999) Is obesity an underlying factor in erectile dysfunction? Eur Urol 36: 68-70
9. De Berardis G, Franciosi M, Belfiglio M et al. (2002) Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes Care 25: 284-291
10. Deutsch S, Sherman L (1980) Previously unrecognized diabetes mellitus in sexually impotent men. JAMA 244: 2430-2432
11. DeWire DM (1996) Evaluation and treatment of erectile dysfunction. Am Fam Physician 53: 2101-2108
12. Esposito K, Giugliano F, Martedi E et al. (2005) High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 28: 1201-1203.
13. Esposito K, Giugliano D (2005) Obesity, the metabolic syndrome, and sexual dysfunction. Int J Impot Res 17: 391-398
14. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285: 2486-2497
15. Feldman HA, Goldstein I, Hatzichristou DG et al. (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol 151: 54-61
16. Feldman HA, Johannes CB, Derby CA et al. (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 30: 328-338
17. Fung MM, Bettencourt R, Barrett-Connor E (2004) Heart disease risk factors predict erectile dysfunction 25 years later: the Rancho Bernardo Study. J Am Coll Cardiol 43: 1405-1411
18. Giuliano FA, Leriche A, Jaudinot EO, de Gendre AS (2004) Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both. Urology 64: 1196-1201
19. Grundy SM, Cleeman JI, Daniels SR et al. (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112: 2735-2752
20. Gündüz MI, Gümüs BH, Sekuri C (2004) Relationship between metabolic syndrome and erectile dysfunction. Asian J Androl 6: 355-358
21. Kalter-Leibovici O, Wainstein J, Ziv A et al. (2005) Clinical, socioeconomic, and lifestyle parameters associated with erectile dysfunction among diabetic men. Diabetes Care 28: 1739-1744
22. Kawanishi Y, Lee KS, Kimura K et al. (2001) Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients. Int J Impot Res 13: 100-103
23. Kim SW, Paick J, Park DW et al. (2001) Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction. Urology 58: 441-445
24. Kirby M, Jackson G, Simonsen U (2005) Endothelial dysfunction links erectile dysfunction to heart disease. Int J Clin Pract 59: 225-229
25. Luscher TF, Noll G (1995) The pathogenesis of cardiovascular disease: role of the endothelium as a target and mediator. Atherosclerosis 118 [Suppl]: 81-90
26. Madamanchi NR, Vendrov A, Runge MS (2005) Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol 25: 29-38
27. Matfin G, Jawa A, Fonseca VA (2005) Erectile dysfunction: interrelationship with the metabolic syndrome. Curr Diab Rep 5: 64-69
28. Montorsi F, Briganti A, Salonia A et al. (2003) Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 44(3): 360-364
29. Penson DF, Latini DM, Lubeck DP et al. (2003) Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database. Diabetes Care 26: 1093-1099
30. Pinnock CB, Stapleton AM, Marshall VR (1999) Erectile dysfunction in the community: a prevalence study. Med J Aust 171: 353-357
31. Ponholzer A, Temml C, Mock K et al. (2005) Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire. Eur Urol 47: 80-85
32. Ponholzer A, Temml C, Obermayr R et al. (2005) Is erectile dysfunction an indicator for increased risk of coronary heart disease and stroke? Eur Urol 48: 512-518
33. Romeo JH, Seftel AD, Madhun ZT, Aron DC (2000) Sexual function in men with diabetes type 2: association with glycemic control. J Urol 163: 788-791
34. Roumeguere T, Wespes E, Carpentier Y et al. (2003) Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 44: 355-359
35. Sairam K, Kulinskaya E, Boustead GB et al. (2001) Prevalence of undiagnosed diabetes mellitus in male erectile dysfunction. BJU Int 88: 68-71
36. Schachter M (2000) Erectile dysfunction and lipid disorders. Curr Med Res Opin 16 [Suppl 1]: 9-12
37. Sommer F, Schulze W (2005) Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors. World J Urol 23(6): 385-392
38. Vicari E, Arcidiacono G, Di Pino L et al. (2005) Incidence of extragenital vascular disease in patients with erectile dysfunction of arterial origin. Int J Impot Res 17: 277-282
39. Walczak MK, Lokhandwala N, Hodge MB, Guay AT (2002) Prevalence of cardiovascular risk factors in erectile dysfunction. J Gend Specif Med 5: 19-24
40. Wirth A (2005) Kardiovaskuläres Risiko beim metabolischen Syndrom. Kardiologie up2date 1: 371-390