Biodistribution and PET imaging of [18F]-fluoroadenosine derivatives

Nuclear Medicine and Biology

Volumn 34, Issue 3, 2007, Pages 267-272

  Alauddin, Mian M ^a   Shahinian, Antranik ^a   Park, Ryan ^a   Tohme, Michael ^a   Fissekis, John D ^a   Conti, Peter S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

18F FAA; 18F FXA; Adenosine; Micro PET

Indexed keywords

2' DEOXY 2' FLUORO 1 BETA DEXTRO ARABINOFURANOSYLADENINE F 18; 3' DEOXY 3' FLUORO 1 BETA DEXTRO XYLOFURANOSYLADENINE F 18; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CELL LINE; DIAGNOSTIC IMAGING; DRUG DISTRIBUTION; FLANK PAIN; HEART; IN VIVO STUDY; INOCULATION; MOUSE; NONHUMAN; NUDE MOUSE; PLASMA CLEARANCE; POSITRON EMISSION TOMOGRAPHY; SPLEEN; TUMOR GROWTH; TUMOR VOLUME; WILD TYPE;

ADENOCARCINOMA; ADENOSINE; ANIMALS; HT29 CELLS; HUMANS; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; ORGAN SPECIFICITY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 33947305259     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2006.12.009     Document Type: Article

References (18)

1. Right J.A., and Taylor N.F. Fluorocarbohydrates. Part XVIII. 9-(3-Deoxy-3-fluoro-(-d-xylofuranosyl)adenine and 9-(3-deoxy-3-fluoro-(-d-arabinofuranosyl)adenine. Carbohydr Res 6 (1968) 347-354
2. Right J.A., Taylor N.F., and Fox J.J. Synthesis of 2-deoxy-2-fluoro-d-arabinose and 9-(2-deoxy-2-fluoro-α- and β-d-arabinofuranosyl)adenine. J Org Chem 34 (1969) 2632-2636
3. Ikehara M., Maruyama T., and Miki H. Studies of nucleosides and nucleotides. LXXIV. Purine cyclonucleoside-34; a new method for the synthesis of 2′-substituted 2′-deoxyadenosine. Tetrahedron 34 (1978) 1133-1138
4. Pankiewicz K.W., Krzeminski J., Ciszeski L.A., Ren W.Y., and Watanabe K.A. A synthesis of 9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine and hypoxanthine. J Org Chem 57 (1992) 553-559
5. Montgomery J.A., Shortnacy-Fowler T.S., Clayton S.D., Riordan J.M., and Secrist J.A. Synthesis and biological activity 2′-fluoro-2-halo-derivatives of 9-β-d-arabinofuranosyladenine. J Med Chem 35 (1992) 397-401
6. Carson D.A., Wasson D.B., Esparza L.M., Carrera C.J., Kipps T., and Cottam H.B. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine. Proc Natl Acad Sci U S A 89 (1992) 2970-2974
7. Takahashi T., Kanazawa J., Akinaga S., Tamoaki T., and Okabe M. Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine, a novel deoxyadenosine analogue, against human colon tumor xenographs by oral administration. Cancer Chemother Pharmacol 43 (1999) 233-240
8. 18F]-fluoroethyluracil. J Pharm Chem 85 (1996) 339-344
9. Mikhailopulo I.A., Poopeiko N.E., Prikota T.I., Sivets G.G., Kvasyuk E.I., Balzirini J., et al. Synthesis and antiviral and cytostatic properties of 3′-deoxy-3′-fluoro- and 2′-azido-3′-fluoro-2′,3′-dideoxy-d-ribofuranosides of natural heterocyclic bases. J Med Chem 34 (1991) 2195-2202
10. Van Aerschot A., Herdewijin P., Jansen G., Cools M., and De clerq E. Synthesis and antiviral activity evaluation of 3′-fluoro-3′-deoxyribonucleosides: broad-spectrum activity of 3′-fluoro-3′-deoxyadenosine. Antiviral Res 12 (1989) 133-150
11. Smee D.F., Morris J.L., Barnard D.L., and Van Aerschot A. Selective inhibition of arthropod-borne and arenaviruses in vitro by 3′-fluoro-3′-deoxyadenosine. Antiviral Res 18 (1992) 151-162
12. Robins M.J., Fouron Y., and Mengel R. Nucleic acid related compounds: 11. Adenosine 2′,3′-ribo-epoxide. Synthesis, intramolecular degradation, and transformation into 3′-substituted xylofuranosyl nucleosides and the lyxo-epoxide. J Org Chem 39 (1974) 1564-1570
13. Lewandowska E., Neschadimenko V., Wnuk S.F., and Robins M.J. Efficient removal of sugar O-tosyl groups and heterocycle halogens from purine nucleosides with sodium naphthalenide. Tetrahedron 53 (1997) 6295-6302
14. Lauer T., Loncar R., and Deussen A. Tracer adenosine: a novel myocardial flow marker. J Nucl Med 44 (2003) 641-648
15. 11C-AMP): a new radioligand for positron emission tomographic imaging of cancer. J Nucl Med 43 (2002) 362P
16. 18F]FMAU). J Labelled Comp Radiopharm 45 (2002) 583-590
17. 18F]-labeled 2′-deoxy-2′-fluoro-1-β-d-arabinofuranosyluracil nucleosides. J Labelled Comp Radiopharm 46 (2003) 285-289
18. 18F]-labeled adenosine analogues as potential PET imaging agents. J Labelled Comp Radiopharm 46 (2003) 805-814