Increased venous versus arterial thrombosis in the Factor V Leiden mouse

Thrombosis Research

Volumn 119, Issue 6, 2007, Pages 747-751

  Cooley, Brian C ^a   Chen, Chao Ying ^a   Schmeling, Gregory ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Arterial thrombosis; Coagulation; Deep vein thrombosis; Factor V; Venous thromboembolism

Indexed keywords

BLOOD CLOTTING FACTOR 5; FERRIC CHLORIDE;

ANASTOMOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; FEMALE; FEMORAL VEIN; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VEIN EMBOLISM; VEIN THROMBOSIS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; ARTERIAL OCCLUSIVE DISEASES; ARTERIES; DISEASE MODELS, ANIMAL; FACTOR V; FERRIC COMPOUNDS; GENE FREQUENCY; GLUTAMINE; HOMOZYGOTE; MICE; MICE, INBRED C57BL; MUTATION; THROMBOSIS; VENOUS THROMBOSIS;

EID: 33947304481     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2006.02.014     Document Type: Article

References (13)

1. Anderson F.A., and Spencer F.A. Risk factors for venous thromboembolism. Circulation 107 (2003) I9-I16
2. Geerts W.H., Heit J.A., Clagett G.P., Pineo G.F., Colwell C.W., Anderson Jr. F.A., et al. Prevention of venous thromboembolism. Chest 119 Suppl. 1 (2001) 132S-175S
3. Juul K., Tybjaerg-Hansen A., Steffensen R., Kofoed S., Jensen G., and Nordestgaard B.G. Factor V Leiden: the Copenhagen City Heart Study and two meta-analyses. Blood 100 (2002) 3-10
4. Kim R.J., and Becker R.C. Association between Factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J 146 (2003) 948-957
5. Dahlback B., Carlsson M., and Svensson P.J. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 90 (1993) 1004-1008
6. Koster T., Rosendaal F.R., de Ronde H., Briet E., Vandenbroucke J.P., and Bertina R.M. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study. Lancet 342 (1993) 1503-1506
7. Bertina R.M., Koeleman B.P.C., Koster T., Rosendaal F.R., Dirven R.J., de Ronde H., et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369 (1994) 64-67
8. Cui J., Eitman D.T., Westrick R.J., Christie P.D., Xu Z.J., Yang A.Y., et al. Spontaneous thrombosis in mice carrying the Factor V Leiden mutation. Blood 96 (2000) 4222-4226
9. Eitzman D.T., Westrick R.J., Shen Y., Bodary P.F., Gu S., Manning S.L., et al. Homozygosity for Factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation 111 (2005) 1822-1825
10. Farrehi P.M., Ozaki C.K., Carmeliet P., and Fay W.P. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation 97 (1998) 1002-1008
11. Cooley B.C., Szema L., Chen C.Y., Schwab J.P., and Schmeling G. Murine model of deep vein thrombosis: characterization and validation in transgenic mice. Thromb Haemost 94 (2005) 498-503
12. Cooley B.C., and Daley R.A. Murine microvascular anastomosis model of thrombosis. Thromb Res 96 (1999) 157-159
13. Foley P.W., Irvine C.D., Standen G.R., Morse C., Smith F.T., McGrath C., et al. Activated protein C resistance, Factor V Leiden and peripheral vascular disease. Cardiovasc Surg 5 (1997) 157-160