Aerosol delivery of muramyl dipeptide to rodent lungs

AAPS PharmSci

Volumn 2, Issue 3, 2000, Pages 1-9

  Pettis, Ronald J ^a   Hall, Iris ^b   Costa, Daniel ^c   Hickey, Anthony J ^b  

^a BD Technologies   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Aerosols; Alveolar Macrophages; Muramyl Dipeptide

Indexed keywords

EID: 33947290088     PISSN: 15221059     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Daniel T, Ellner J. Immunology of Tuberculosis. In: Reichman L, Hershfield E, eds. Tuberculosis. New York: Marcel Dekker; 1993:75-101.
2. Pelczar M, Chan E, Krieg N. Microbiology. New York: McGraw-Hill; 1986:815-818.
3. Lederer E. Recent progress in the study of natural and synthetic immunomodulators derived from bacterial cell walls. In: Yamamura Y, Kotani S, eds. Immunomodulation by Microbial Products and Related Synthetic Compounds. Princeton, NJ: Excerpta Medica; 1992:3-16.
4. Burleson G. Pulmonary immunocompetence and pulmonary immunotoxicology. In: Smialowicz R, Holsapple M, eds. Experimental Immunotoxicology. Boca Raton, FL: CRC Press; 1995:119-141.
5. Fidler I. Systemic macrophage activation with liposomeentrapped immunomodulators for therapy of cancer metastases. Res in Immunol. 1992;143:199-204.
6. Phillips N, Chedid L, Bernard J, Level M, Lefrancier P. Induction of murine macrophage tumoricidal activity and treatment of experimental pulmonary metastases by liposomes containing lipophilic muramyl dipeptide analogs. J Biol Resp Mod. 1987;6:678-690.
7. Sone S, Tachibana K, Shoho M, Ogushi F, Tsubura E. Potential value of liposomes containing muramyl dipeptide for augmenting the tumoricidal activity of human alveolar macrophages. J Biol Resp Mod. 1984;3:185-194.
8. Phillips N, Moras M, Chedid L, et al. Activation of macrophage cytostatic and cytotoxic activity in vitro by liposomes containing a new lipophilic muramyl peptide derivative, MDP-L-alanyl-cholesterol (MTP-CHOL). J Biol Resp Mod. 1985;4:464-474.
9. Hickey A. Summary of common approaches to pharmaceutical aerosol administration. In: Hickey A, ed. Pharmaceutical Inhalation Aerosol Technology. New York: Marcel Dekker; 1992:255-288.
10. Altiere R, Thompson D. Physiology and pharmacology of the lung. In: Hickey A, ed. Inhalation Aerosols: Physical and Biological Basis for Therapy. New York: Marcel Dekker; 1996:85-137.
11. Hickey A, Suarez S, Bhat M, et al. Efficacy of rifampicinpoly(lactide-co-glycolide) microspheres in treating tuberculosis. In: Dalby R, Byron P, Fair S, eds. Respiratory Drug Delivery VI. Buffalo Grove, IL: Interpharm Press; 1998:201-209.
12. Chaffee V. Surgery of laboratory animals. In: Melby E, Altman N, eds. Handbook of Laboratory Animal Science. Boca Raton, FL: CRC Press. 1974;263.
13. 13. Seyler I, Morin C, Barrait G, Appel M, Devissaguet J-P, Puisieux F. Induction of macrophage NO-synthase by an immunomodulator entrapped within polymeric nanocapsules. Eur J Pharm Biopharm. 1995;41:49-54.
14. 2 inhibitor. J Pharm Exp Ther. 1996;278:252-257.
15. 15. Neldon D, Lange R, Rosenthal G, Comment C, Burleson G. Macrophage nonspecific phagocytosis assays. In: Burleson G, Dean J, Munson A, eds. Methods in Immunotoxicology. Vol. 2. New York: Wiley-Liss; 1995:39-57.
16. 16. Leibovitz A, Stinson I, McComb III W, McCoy C, Mazur K, Mabry N. Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 1976;36:4562-4569.
17. 17. Gibaldi M. What is nitric oxide and why are so many people studying it? J Clin Pharmacol. 1993;33:488-496.
18. 18. Jorens P, Van Overeld F, Bult H, Vermeire P, Herman A. Serine-protease inhibitors modulate nitric oxide-synthase activity of alveolar macrophages. Agents Actions. 1992;36:243-247.
19. 19. Pettis R, Hall I, Hickey A. Effect of muramyl dipeptide aerosols on guinea pig alveolar macrophages. Pharm Res. 1996;13:S166.
20. 20. Pettis R, Hickey A. Aerosol delivery of peptide immunomodulators to rodent lungs. In: Tarn J, Kaumaya P, eds. Peptides: Frontiers of Peptide Science. Boston, MA: Kluwer Academic Publishers; 1999:845-846.