Physiopathology of bacterial translocation and spontaneous bacterial peritonitis in cirrhosis;Fisiopatología de la translocación y la peritonitis bacteriana espontánea en la cirrosis

Gastroenterologia y Hepatologia

Volumn 30, Issue 2, 2007, Pages 78-84

  González Alonso, Rosario ^a   González García, Mónica ^a   Albillos Martínez, Agustín ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; CISAPRIDE; CYTOKINE; GLUTAMIC ACID; PROPRANOLOL; QUINOLONE;

ASCITES FLUID; BACTERIAL FLORA; BACTERIAL PERITONITIS; BACTERIAL TRANSLOCATION; ENTEROBACTERIACEAE; HUMAN; KIDNEY FAILURE; LIVER CIRRHOSIS; MICROBIAL GROWTH; REVIEW; VASODILATATION;

EID: 33947254137     PISSN: 02105705     EISSN: None     Source Type: Journal    
DOI: 10.1157/13099277     Document Type: Article

References (50)

1. Navasa M, Rodes J. Bacterial infections in cirrhosis. Liver Int. 2004;24:277-80.
2. Albillos A, Cuervas-Mons V, Millán I, et al. Ascitic fluid polymorphonuclear cell count and serum to ascites albumin gradient in the diagnosis of bacterial peritonitis. Gastroenterology. 1990;98:134-40.
3. Rimola A, Navasa M. Infections in liver disease. En: Bircher J, Benhamou J-P, McIntyre N, Rizzetto M, Rodés J, editors. Oxford textbook of clinical hepatology. 2nd ed. New York: Oxford University Press; 1999. p. 1862-74.
4. García-Tsao G. Spontaneous bacterial peritonitis. Gastroenterol Clin North Am. 1992;21:257-5.
5. Gines P, Rimola A, Planas R, et al. Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: Results of a double-blind, placebo controlled trial. Hepatology. 1990;12:716-24.
6. Runyon BA. Low-protein concentration ascitic fluid is predisposed to spontaneous bacterial peritonitis. Gastroenterology. 1986;91:1343-6.
7. Follo A, Llovet JM, Navasa M, et al. Renal impairment after spontaneous bacterial peritonitis in cirrhosis: incidence, clinical course, predictive factors and prognosis. Hepatology. 1994;20:1495-501.
8. Runyon BA, Squier S, Borzio M. Translocation of gut bacteria in rats with cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis. J Hepatol. 1994;21:792-6.
9. García-Tsao G, Lee FY, Barden GE, Cartun R, West AB. Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites. Gastroenterology. 1995;108:1835-41.
10. Wiest R, Rath HC. Gastrointestinal disorders of the critically ill. Bacterial translocation in the gut. Best Pract Res Clin Gastroenterol. 2003;17:397-425.
11. Such J, Frances R, Munoz C, et al. Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites. Hepatology. 2002;36:135-41.
12. Albillos A, De la Hera A, González M, et al. Increased polysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement. Hepatology. 2003;37:208-17.
13. Pérez-Paramo M, Muñoz J, Albillos A, et al. Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites. Hepatology. 2000;1:43-8.
14. O'Boyle CJ, McFie J, Dave K, Sagar PS, Poon P, Mitchell CJ. Alterations in intestinal barrier function do not predispose to translocation of enteric bacteria in gastroenterological patients. Nutrition. 1998;14:358-62.
15. Llovet JM, Bartoli R, Planas R, et al. Bacterial translocation in cirrhotic rats. Its role in the development of spontaneous bacterial peritonitis. Gut. 1994;35:1648-52.
16. Guarner C, Runyon BA, Young S, Heck M, Sheikh MY. Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites. J Hepatol. 1997;26:1372-8.
17. Llovet JM, Bartoli R, March F, et al. Translocated intestinal bacteria cause spontaneous bacterial peritonitis in cirrhotic rats: molecular epidemiologic evidence. J Hepatol. 1998;28:307-13.
18. Cirera I, Bauer TM, Navasa M, et al. Bacterial translocation of enteric organisms in patients with cirrhosis. J Hepatol. 2001;34:32-7.
19. Sedman B, MacFie J, Sagar P, et al. The prevalence of gut translocation in humans. Gastroenterology. 1994;107:643-9.
20. Chan CS, Chen GH, Lien HC, Yen HZ. Small intestinal dismotility and bacterial overgrowth in cirrhotic patients with spontaneous bacterial peritonitis. Hepatology. 1998;28:1187-90.
21. Pardo A, Bartolí R, Lorenzo-Zuñiga V, et al. Effect of cisapride on intestinal bacterial overgrowth and bacterial translocation in cirrhosis. Hepatology. 2000;31:858-63.
22. Ramachandran A, Prabhu R, Thomas S, Reddy JB, Pulimood A, Balasubramanian KA. Intestinal mucosal alterations in experimental cirrhosis in the rat: role of oxygen free radicals. Hepatology. 2002;35:622-9.
23. Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstien S, Groszmann RJ. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. J Clin Invest. 1999;104:1223-33.
24. Unno N, Wang H, Menconi MJ, et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology. 1997;113:1246-57.
25. Rajkovic IA, Williams R. Abnormalities of neutrophil phagocytosis, intracellular killing and metabolic activity in alcoholic cirrhosis and hepatitis. Hepatology. 1986;6:252-62.
26. Gomez F, Ruiz P, Schreiber AD. Impaired function of macrophage Fcy receptor and bacterial infection in alcoholic cirrhosis. N Engl J Med. 1994;331:1122-8.
27. Panés J, Pérez-del-Pulgar S, Casadevall M, et al. Impaired mesenteric leukocyte recruitment in experimental portal hypertension in the rat. Hepatology. 1999;30:445-53.
28. Rimola A, Soto R, Bory F, et al. Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis. Hepatology. 1984;4:53-8.
29. Runyon BA, Borzio M, Young S, Squier SU, Guarner C, Runyon MA. Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis. Hepatology. 1995;21:1719-24.
30. Guarner C, Runyon BA, Heck M, Young S, Sheikh MY. Effect of long-term trimethoprim-sulfamethoxazole prophylaxis on ascites formation, bacterial translocation, spontaneous bacterial peritonitis, and survival in cirrhotic rats. Dig Dis Sci. 1999;44:1957-62.
31. González-Suárez B, Guarner C, Miñana J, et al. Pharmacologic treatment of portal hypertension contributes to prevent community-acquired spontaneous bacterial peritonitis (SBP). J Hepatol. 2000;32 Suppl 2:42A.
32. Bauer TM, Fernández J, Navasa M, Vila J, Rodes J. Failure of Lactobacillus spp. to prevent bacterial translocation in a rat model of experimental cirrhosis. J Hepatol. 2002;36:501-6.
33. Lorenzo-Zuniga V, Bartoli R, Planas R, et al. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology. 2003;37:551-7.
34. Chiva M, Soriano G, Rochat I, et al. Effect of Lactobacillus johnsoni La1 and antioxidants on intestinal flora and bacterial traslocation in rats with experimental cirrhosis. J Hepatol. 2002;37:456-61.
35. Schimpl G, Pabst MA, Feierl G, Kuesz A, Özbey H, Takahashi S, Höllwarth ME. A tungsten supplemented diet attenuates bacterial translocation in chronic portal hypertensive and cholestatic rats: role of xanthine dehydrogenase and xanthine oxidase. Gut. 1999;45:904-10.
36. Schimpl G, Pesendorfer P, Steinwender G, et al. Allopurinol reduces bacterial translocation, intestinal mucosal lipid peroxidation, and neutrophil-derived myeloperoxidase activity in chronic portal hypertensive and common bile duct-ligated growing rats. Pediatr Res. 1996;40:422-8.
37. Genescà J, Martí R, Rojo F, Campos F, et al. Increased tumor necrosis factor alpha production in mesenteric lymph nodes of cirrhotic patients with ascites. Gut. 2003;52:1054-9.
38. Muñoz L, Albillos A, Nieto M, et al. Mesenteric Th1 polarization and monocyte TNF-α production: first steps to systemic inflammation in rats with cirrhosis. Hepatology. 2005;42:411-9.
39. Riordan SM, Skinner N, Nagree A, McCallum H, McIver CJ, Kurtovic J, et al. Peripheral blood mononuclear cell expression of Toll-like receptors and relation to cytokine levels in cirrhosis. Hepatology. 2003;37:1154-64.
40. Albillos A, De la Hera A, Reyes E, et al. Tumor necrosis factor-alpha expression by activated monocytes and altered T-cell homeostasis in ascitic alcoholic cirrhosis: amelioration with norfloxacin. J Hepatol. 2004;40:624-31.
41. Frances R, Benlloch S, Zapater P, et al. A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites. Hepatology. 2004;39:484-91.
42. Such J, Muñoz C, Zapater P, et al. Bacterial DNA induces a proinflammatory inmunitario response in patients with descompensated cirrhosis. Gut. 2005;54:1500.
43. Albillos A, De la Hera A, Montserrat J, Valero A, Ruiz del Árbol L, Calleja JL, et al. La descontaminación intestinal selectiva revierte la activación del sistema inmune y mejora la vasodilatación periférica en pacientes cirróticos con translocación bacteriana. Gastroenterol Hepatol. 2001;24:82A.
44. Guarner C, Soriano G, Tomás A, Bulbena O, Novella MT, Balanzó J, et al. Increased serum nitrates and nitrate levels in patients with cirrhosis; relationship to endotoxinemia. Hepatology. 1993;18:1139-43.
45. Morales-Ruiz M, Tugues S, Cejudo-Martín P, et al. Ascites from cirhotic patients induces angiogenesis through the phosphoinositide 3-kinase/Akt signaling pathway. J Hepatol. 2005;43:85-91.
46. Pérez-Ruiz M, Ros J, Morales-Ruiz M, et al. Vascular endothelial growth factor production in peritoneal macrophages of cirrhotic patients: regulation by cytokines and bacterial lipopolysacaharide. Hepatology. 1999;29:1057-63.
47. Francés R, Muñoz C, Zapater P, et al. Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites. Gut. 2004;53:860-4.
48. Cejudo-Martín P, Ros J, Navasa M, et al. Inceased production of vascular endotelial growth factor in peritoneal macrophages of cirrhotic patients with spontaneous bacterial peritonitis. Hepatology. 2001;34:487-93.
49. Navasa M, Follo A, Filella X, Jiménez W, Francitorra A, Planas R, et al. Tumor necrosis factor and interleukin-6 in spontaneous bacterial peritonitis in cirrhosis: relationship with the development of renal impairment and mortality. Hepatology. 1998;27:1227-32.
50. Sort P, Navasa M, Arroyo V, et al. Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med. 1999;5:403-9.