Immunolocalization of glial cell-derived neurotrophic factor (GDNF) and its receptor GFR-α1 in varicocele-induced rat testis

Acta Histochemica

Volumn 109, Issue 2, 2007, Pages 130-137

  Akkoyunlu, Gökhan ^a   Erdoǧru, Tibet ^a   Seval, Yasemin ^a   Üstünel, Ismail ^a   Köksal, Türker ^a   Usta, Mustafa F ^a   Baykara, Mehmet ^a   Demir, Ramazan ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

GDNF; GFR 1; Rats; Spermatogenesis; Testicular dysfunction; Varicocele

Indexed keywords

CYTOLOGY; HISTOLOGY; IMMUNOLOGY; LIVING SYSTEMS STUDIES; NEUROLOGY; RATS;

GFRΑ1; GLIAL CELL DERIVED NEUROTROPHIC FACTOR (GDNF); SPERMATOGENESIS; TESTICULAR DYSFUNCTION; VARICOCELES;

CELLS;

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA1; PARAFFIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; LEYDIG CELL; MALE; NONHUMAN; ORCHIECTOMY; PROTEIN LOCALIZATION; RAT; SPERMATID; SPERMATOGENESIS; TESTIS; VARICOCELE;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 33947215453     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2006.11.003     Document Type: Article

References (20)

1. Barqawi A., Caruso A., and Meacham R.B. Experimental varicocele induces testicular germ cell apoptosis in the rat. J Urol 171 (2004) 501-503
2. Celik-Ozenci C., Bayram Z., Akkoyunlu G., Korgun E.T., Erdogru T., Seval Y., et al. Localization of NGF and nNOS in varicocele-induced rat testis. Acta Histochem 107 (2006) 435-442
3. Comhaire F., and Vermeulen A. Plasma testosterone in patients with varicocele and sexual inadequacy. J Clin Endocrinol Metab 40 (1975) 824-829
4. Davidoff M.S., Middendorff R., Koeva Y., Pusch W., Jezek D., and Muller D. Glial cell line-derived neurotrophic factor (GDNF) and its receptors GFRalpha-1 and GFRalpha-2 in the human testis. Ital J Anat Embryol 106 (2001) 173-180
5. Dettin L., Ravindranath N., Hofmann M.C., and Dym M. Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis. Biol Reprod 69 (2003) 1565-1571
6. Dubin L., and Amelar R.D. Etiologic factors in 1294 consecutive cases of male infertility. Fertil Steril 22 (1971) 469-474
7. Durbec P., Marcos-Gutierrez C.V., Kilkenny C., Grigoriou M., Wartiowaara K., Suvanto P., et al. GDNF signalling through the Ret receptor tyrosine kinase. Nature 381 (1996) 789-793
8. Gorelick J.I., and Goldstein M. Loss of fertility in men with varicocele. Fertil Steril 59 (1993) 613-616
9. Hu J., Shima H., and Nakagawa H. Glial cell line-derived neurotropic factor stimulates Sertoli cell proliferation in the early postnatal period of rat testis development. Endocrinology 140 (1999) 3416-3421
10. Marmar J.L. The pathophysiology of varicoceles in the light of current molecular and genetic information. Hum Reprod Update 7 (2001) 461-472
11. Meng X., Lindahl M., Hyvonen M.E., Parvinen M., de Rooij D.G., Hess M.W., et al. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 287 (2000) 1489-1493
12. Naughton C.K., Nangia A.K., and Agarwal A. Pathophysiology of varicoceles in male infertility. Hum Reprod Update 7 (2001) 473-481
13. Naughton C.K., Jain S., Strickland A.M., Gupta A., and Milbrandt J. Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Biol Reprod 74 (2006) 314-321
14. Sahin Z., Bayram Z., Celik-Ozenci C., Akkoyunlu G., Seval Y., Erdogru T., et al. Effect of experimental varicocele on the expressions of notch 1, 2, and 3 in rat testes: an immunohistochemical study. Fertil Steril 83 (2005) 86-94
15. Sariola H., and Saarma M. Novel functions and signalling pathways for GDNF. J Cell Sci 116 (2003) 3855-3862
16. Saypol D.C., Howards S.S., Turner T.T., and Miller Jr. E.D. Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs. J Clin Invest 68 (1981) 39-45
17. Schlatt S., Meinhardt A., and Nieschlag E. Paracrine regulation of cellular interactions in the testis: factors in search of a function. Eur J Endocrinol 137 (1997) 107-117
18. Trupp M., Ryden M., Jornvall H., Funakoshi H., Timmusk T., Arenas E., et al. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. J Cell Biol 130 (1995) 137-148
19. Viglietto G., Dolci S., Bruni P., Baldassarre G., Chiariotti L., Melillo R.M., et al. Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia. Int J Oncol 16 (2000) 689-694
20. Widenfalk J., Parvinen M., Lindqvist E., and Olson L. Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell Tissue Res 299 (2000) 409-415