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Volumn 4, Issue 1, 2007, Pages 43-51

Molecular mechanisms for the antitumor activity of inositol hexakisphosphate (IP6)

Author keywords

Apoptosis; Cell differentiation; IP6; K 562 leukemia cells; Microarray; Pathway

Indexed keywords

BENZIDINE; PHYTIC ACID; PROTEIN BAX; PROTEIN BCL 2;

EID: 33947210819     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (29)

References (42)
  • 2
    • 0029036869 scopus 로고
    • Metabolism and biological activities of inositol pentakisphosphate and inositol hexakisphosphate
    • Noboyuki S, Mohamed S and Michael RH: Metabolism and biological activities of inositol pentakisphosphate and inositol hexakisphosphate. Biochemical Pharmacology 50(2): 137-146, 1995.
    • (1995) Biochemical Pharmacology , vol.50 , Issue.2 , pp. 137-146
    • Noboyuki, S.1    Mohamed, S.2    Michael, R.H.3
  • 3
    • 0035087311 scopus 로고    scopus 로고
    • Assessing the omnipotence of inositol hexakisphosphate
    • Shears SB: Assessing the omnipotence of inositol hexakisphosphate. Cell Signal 13(3): 151-158, 2001.
    • (2001) Cell Signal , vol.13 , Issue.3 , pp. 151-158
    • Shears, S.B.1
  • 5
    • 0029968296 scopus 로고    scopus 로고
    • Phosphoinositides as regulators in membrane traffic
    • De Camilli P, Emr SD, McPherson PS and Novick P: Phosphoinositides as regulators in membrane traffic. Science 271(5255): 1533-1539, 1996.
    • (1996) Science , vol.271 , Issue.5255 , pp. 1533-1539
    • De Camilli, P.1    Emr, S.D.2    McPherson, P.S.3    Novick, P.4
  • 6
    • 0033843586 scopus 로고    scopus 로고
    • Transcriptional regulation: A new dominion for inositol phosphate signaling?
    • Shears SB: Transcriptional regulation: a new dominion for inositol phosphate signaling? BioEssays 22: 786-789, 2000.
    • (2000) BioEssays , vol.22 , pp. 786-789
    • Shears, S.B.1
  • 7
    • 0034664805 scopus 로고    scopus 로고
    • Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair
    • Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D and West SC: Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair. Cell 102(6): 721-729, 2000.
    • (2000) Cell , vol.102 , Issue.6 , pp. 721-729
    • Hanakahi, L.A.1    Bartlet-Jones, M.2    Chappell, C.3    Pappin, D.4    West, S.C.5
  • 8
    • 0028182572 scopus 로고
    • 3H]inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro
    • 3H]inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. J Nutr 124(6): 861-868, 1994.
    • (1994) J Nutr , vol.124 , Issue.6 , pp. 861-868
    • Vucenik, I.1    Shamsuddin, A.M.2
  • 9
    • 24144458553 scopus 로고    scopus 로고
    • Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats
    • Zhang Z, Song Y and Wang X-L: Inositol hexaphosphate-induced enhancement of natural killer cell activity correlates with suppression of colon carcinogenesis in rats. World J Gastroenterol 11(32): 5044-5046, 2005.
    • (2005) World J Gastroenterol , vol.11 , Issue.32 , pp. 5044-5046
    • Zhang, Z.1    Song, Y.2    Wang, X.-L.3
  • 10
    • 0029122135 scopus 로고
    • Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells
    • Shamsuddin AM and Yang GY: Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Carcinogenesis 16: 1975-1979, 1995.
    • (1995) Carcinogenesis , vol.16 , pp. 1975-1979
    • Shamsuddin, A.M.1    Yang, G.Y.2
  • 11
    • 0032787043 scopus 로고    scopus 로고
    • Chemoprevention of pulmonary carcinogenesis by myo-inositol
    • Wattenberg LW: Chemoprevention of pulmonary carcinogenesis by myo-inositol. Anticancer Res 19: 3659-3662, 1999.
    • (1999) Anticancer Res , vol.19 , pp. 3659-3662
    • Wattenberg, L.W.1
  • 12
    • 0032217236 scopus 로고    scopus 로고
    • 6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line. Anticancer Res 18(6A): 4083-4090, 1998.
    • 6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line. Anticancer Res 18(6A): 4083-4090, 1998.
  • 14
    • 0033843586 scopus 로고    scopus 로고
    • Transcriptional regulation: A new dominion for inositol phosphate signaling?
    • Shears SB: Transcriptional regulation: a new dominion for inositol phosphate signaling? Bio Essays 22: 786-789, 2000.
    • (2000) Bio Essays , vol.22 , pp. 786-789
    • Shears, S.B.1
  • 15
    • 0024453294 scopus 로고
    • Inositol phosphates and cell signalling
    • Berridge M J and Irvine RF: Inositol phosphates and cell signalling. Nature 341: 197-205, 1989.
    • (1989) Nature , vol.341 , pp. 197-205
    • Berridge, M.J.1    Irvine, R.F.2
  • 16
    • 0030793370 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3′ kinase
    • Huang C, Ma W-Y, Hecht SS and Dong Z: Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3′ kinase. Cancer Research 57(14): 2873-2878, 1997.
    • (1997) Cancer Research , vol.57 , Issue.14 , pp. 2873-2878
    • Huang, C.1    Ma, W.-Y.2    Hecht, S.S.3    Dong, Z.4
  • 18
  • 19
    • 18844380261 scopus 로고    scopus 로고
    • 6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation
    • 6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat 91(1): 35-45, 2005.
    • (2005) Breast Cancer Res Treat , vol.91 , Issue.1 , pp. 35-45
    • Vucenik, I.1    Ramakrishna, G.2    Tantivejkul, K.3    Anderson, L.M.4    Ramljak, D.5
  • 20
    • 0036964804 scopus 로고    scopus 로고
    • Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway
    • Ferry S, Matsuda M, Yoshida H and Hirata M: Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway. Carcinogenesis 23(12): 2031-2041, 2002.
    • (2002) Carcinogenesis , vol.23 , Issue.12 , pp. 2031-2041
    • Ferry, S.1    Matsuda, M.2    Yoshida, H.3    Hirata, M.4
  • 21
    • 0345107253 scopus 로고    scopus 로고
    • 6) inhibits key events of cancer metastasis: II Effects on integrins and focal adhesions. Anticancer Res 23(5A): 3681-3689, 2003.
    • 6) inhibits key events of cancer metastasis: II Effects on integrins and focal adhesions. Anticancer Res 23(5A): 3681-3689, 2003.
  • 23
    • 0031050089 scopus 로고    scopus 로고
    • Phillippy BQ and Graf E: Antioxidant functions of inositol 1,2,3/trisphosphate and inositol 1,2,3,6-tetrakisphosphate. Free Radic Biol Med 22(6): 939-946, 1997.
    • Phillippy BQ and Graf E: Antioxidant functions of inositol 1,2,3/trisphosphate and inositol 1,2,3,6-tetrakisphosphate. Free Radic Biol Med 22(6): 939-946, 1997.
  • 25
    • 0024425063 scopus 로고
    • Inositol-phosphate- induced enchancement of natural killer cell activity correlates with tumor suppression
    • Baten A, Ullah A, Tomazic VJ and Shamsuddin AM: Inositol-phosphate- induced enchancement of natural killer cell activity correlates with tumor suppression. Carcinogenesis 10(9): 1595-1598, 1989.
    • (1989) Carcinogenesis , vol.10 , Issue.9 , pp. 1595-1598
    • Baten, A.1    Ullah, A.2    Tomazic, V.J.3    Shamsuddin, A.M.4
  • 26
    • 0026780284 scopus 로고
    • Effect of inositol hexaphosphate on growth and differentiation in K-562 erythroleukemia cell line
    • Shamsuddin AM, Baten A and Lalwani ND: Effect of inositol hexaphosphate on growth and differentiation in K-562 erythroleukemia cell line. Cancer Lett 64: 195-202, 1992.
    • (1992) Cancer Lett , vol.64 , pp. 195-202
    • Shamsuddin, A.M.1    Baten, A.2    Lalwani, N.D.3
  • 27
    • 0033832805 scopus 로고    scopus 로고
    • GTP-mediated differentiation of the human K562 cell line: Transient overexpression of GATA-1 and stabilization of gamma-globin mRNA
    • Morceau F, Dupont C, Palissot V, Borde-Chiche P, Trentesaux C, Dicato M and Diederich M: GTP-mediated differentiation of the human K562 cell line: transient overexpression of GATA-1 and stabilization of gamma-globin mRNA. Leukemia 14(9): 1589-1597, 2000.
    • (2000) Leukemia , vol.14 , Issue.9 , pp. 1589-1597
    • Morceau, F.1    Dupont, C.2    Palissot, V.3    Borde-Chiche, P.4    Trentesaux, C.5    Dicato, M.6    Diederich, M.7
  • 28
    • 0030499776 scopus 로고    scopus 로고
    • 6: growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res 16(6A): 3287-3292, 1996.
    • 6: growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res 16(6A): 3287-3292, 1996.
  • 29
    • 0032763994 scopus 로고    scopus 로고
    • 6: a review. Anticancer Res 19(5A): 3733-3736, 1999.
    • 6: a review. Anticancer Res 19(5A): 3733-3736, 1999.
  • 30
    • 0031856814 scopus 로고    scopus 로고
    • Vucenik I, Kalebic T, Tantivejkul K and Shamsuddin AM: Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res 18(3A): 1377-1384, 1998.
    • Vucenik I, Kalebic T, Tantivejkul K and Shamsuddin AM: Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res 18(3A): 1377-1384, 1998.
  • 33
    • 13444312083 scopus 로고    scopus 로고
    • Mi H, Lazareva-Ulitsky B, Loo R, Kejariwal A, Vandergriff J, Rabkin S, Guo N, Muruganujan A, Doremieux O, Campbell MJ, Kitano H and Thomas PD: The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res 1;33(Database issue): D284-288, 2005.
    • Mi H, Lazareva-Ulitsky B, Loo R, Kejariwal A, Vandergriff J, Rabkin S, Guo N, Muruganujan A, Doremieux O, Campbell MJ, Kitano H and Thomas PD: The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res 1;33(Database issue): D284-288, 2005.
  • 34
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4): 402-408, 2001.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 35
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog , Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog , Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 36
    • 0033011229 scopus 로고    scopus 로고
    • Inositol hexaphosphate reduces 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase independent of protein kinase C isoform expression in keratinocytes
    • Nickel KP and Belury MA: Inositol hexaphosphate reduces 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase independent of protein kinase C isoform expression in keratinocytes. Cancer Letters 140: 105-111, 1999.
    • (1999) Cancer Letters , vol.140 , pp. 105-111
    • Nickel, K.P.1    Belury, M.A.2
  • 37
    • 14644399796 scopus 로고    scopus 로고
    • Histone metabolic pathways and chromatin assembly factors as proliferation markers
    • Polo SE and Almouzni G: Histone metabolic pathways and chromatin assembly factors as proliferation markers. Cancer Letters 220: 1-9, 2005.
    • (2005) Cancer Letters , vol.220 , pp. 1-9
    • Polo, S.E.1    Almouzni, G.2
  • 38
    • 0028958708 scopus 로고
    • Telomeres and telomerase in aging and cancer
    • Harley CB and Villeponteau B: Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev 5: 249-255, 1995.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 249-255
    • Harley, C.B.1    Villeponteau, B.2
  • 40
    • 33745809878 scopus 로고    scopus 로고
    • Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate
    • Weglarz L, Molin I, Orchel A, Pafiniewitz B and Dzierzewicz Z: Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate. Acta Biochim Pol 53(2): 349-356, 2006.
    • (2006) Acta Biochim Pol , vol.53 , Issue.2 , pp. 349-356
    • Weglarz, L.1    Molin, I.2    Orchel, A.3    Pafiniewitz, B.4    Dzierzewicz, Z.5
  • 42
    • 33644974753 scopus 로고    scopus 로고
    • Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation
    • Rangatia J and Bonnet D: Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia 20(1): 68-76, 2006.
    • (2006) Leukemia , vol.20 , Issue.1 , pp. 68-76
    • Rangatia, J.1    Bonnet, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.