Management of sensitized patients awaiting renal transplantation: Does sequential therapy of intravenous immunoglobulin and simvastatin offer a solution?

European Journal of Pharmacology

Volumn 561, Issue 1-3, 2007, Pages 202-205

  Mahmoud, Khaled M ^a   Sobh, Mohamed A ^a   El Shenawy, Farha ^a   Isamil, Amani M ^a   El Magd, Megahed Abo ^a   Hassan, Nabil A ^a   El Agroudy, Amgad E ^a   Sheashaa, Hussein A ^a   Opelz, Gerhard ^b   Ghoneim, Mohamed A ^a  

^a MANSOURA UNIVERSITY   (Egypt)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

HLA alloantibody; Intravenous immunoglobulin; Renal transplantation; Sensitization; Simvastatin

Indexed keywords

HLA ANTIBODY; IMMUNOGLOBULIN; SIMVASTATIN;

ABSENCE OF SIDE EFFECTS; ADULT; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HLA MATCHING; HUMAN; HUMAN TISSUE; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; SENSITIZATION;

ADULT; DESENSITIZATION, IMMUNOLOGIC; DRUG THERAPY, COMBINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOLOGIC FACTORS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; RENAL DIALYSIS; SIMVASTATIN;

EID: 33947206610     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.12.035     Document Type: Article

References (19)

1. Al-Uzri A.Y., Seltz B., Peter D., Catherine M., and Kenneth A. Successful renal transplant outcome after intravenous gamma-globulin treatment of a highly sensitized pediatric recipient. Pediatr. Transplant. 6 (2002) 161-163
2. Feinstein LC., Seidel K., and Jocum J. Reduced dose intravenous immunoglobuline does not decrease transplant related complications in adults given related marrow allografts. Biol. Blood Marrow Transplant. 5 (1999) 369-378
3. Glotz D., Haymann J.P., and Sansonetti N. Suppression of HLA-specific alloantibodies by high-dose intravenous immunoglobulins. A potential tool for transplantation of immunized patients. Transplantation 56 (1993) 335-339
4. Glotz D., Antoine C., Julia P., Suberbielle-Boissel C., Boudjeltia S., Fraoui R., Hacen C., Duboust A., and Bariety. Desensitization and subsequent kidney transplantation of patients using intravenous immunoglobulins. Am. J. Transplant. 2 (2002) 758-760
5. Hiesse C., Kriaa F., and Rousseau P. Immunoadsorption of anti-HLA antibodies for highly sensitized patients awaiting renal transplantation. Nephrol. Dial. Transplant. 7 (1992) 944-947
6. John R., Lietz E., and Bruke J. Intravenous immunoglobulins reduces anti-HLA alloreactivity and shortens waiting time to cardiac transplantation in highly sensitized left ventricular assist device recipients. Circulation 100 (1999) 11229-11235
7. Jordan S., Tyan D., Czer L., and Toyoda M. Immunomodulatory actions of intravenous immunoglobulin (IVIG): potential applications in solid organ transplant recipients. Pediatr. Transplant. 2 (1998) 92-96
8. Jordan S., Tyan D., Stablein D., McIntosh M., Rose S., Toyoda M., Davis C., Shapiro R., Adey D., Milliner D., Graff R., and Light J. Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trial. J. Am. Soc. Nephrol. 15 (2004) 3256-3262
9. Katznelson S. Dual roles of HMG-CoA reductase inhibitors in solid organ transplantation: lipid lowering and immunosuppression. Kidney Int. 52 (1995) S112-S115
10. Kupin W., Venkat K., Heung K., Moses M., Hayash H., and Watt R. Immunoabsorption therapy for highly sensitized renal transplant recipients (Abstract). Am. Soc. Transplant. Phys. 83 (1990)
11. Massad M.G., Cook D.J., Schmitt S.K., Smedira N.G., McCarthy J.F., Vargo R.L., and McCarthy P.M. Factors influencing HLA sensitization in implantable LVAD recipients. Ann. Thorac. Surg. 64 (1997) 1120-1125
12. Ozdemir F.N., Sezer S., Turan M., Colak T., Arat Z., Gulmus S., and Haberal M. The effect of simvastatin on panel-reactive antibody and crossmatch positivity. Transplant. Proc. 33 (2001) 2842-2843
13. Raimondi E., Casadei D., and Rusch R. IVIG in high dose to inhibit lymphocyte activity of allogenic anti-HLA antibodies. Hum. Immunol. 37 (1993) 1993-1994
14. Schweitzer E.J., Wilson J.S., Fernandez-Vina M., Fox M., Gutierrez M., Wiland A., Hunter J., Farney A., Philosophe B., Colonna J., Jarrell B.E., and Bartlett S.T. A high panel-reactive antibody rescue protocol for cross-match-positive live donor kidney transplants. Transplantation 70 (2000) 1531-1536
15. Scornick J.C., Saomon D., Fennell R.S., Howard R.J., and Pfaff W. Immunosuppression as effective treatment for presensitization in renal transplant candidates (Abstract). Am. Soc. Transplant. Phys. 82 (1990)
16. Terasaki P.J., and Mc Cellond I.D. Microdroplet assay of human serum cytotoxins. Quoted from Patel, R. and Mocelin, A.: tissue typing in human kidney transplantation: a review. J. Urol. 107 (1972) 684-692
17. Urra J.M., de la Torre M., Alcazar R., Peces R., and Garcia-Chico P. Variable in vitro inhibition of HLA specific alloantibody mediated cytotoxicity by intervenous immunoglobulin. Transplant. Proc. 30 (1998) 4177-4179
18. Wadstrom J., Gannedahl G., and Bersz X. Successful kidney transplantation after suppression of HLA alloantibodies with intravenous immunoglobulin in a highly sensitized patient. Transplant. Proc. 27 (1995) 3463
19. Wang G., Terasaki C., Schen M., and Lee J.H. A new micro ELISA for anti class I and class II antibodies detection. Hum. Immunol. 59 (1998) 133-138