The respiratory drive to thoracic motoneurones in the cat and its relation to the connections from expiratory bulbospinal neurones

Journal of Physiology

Volumn 579, Issue 3, 2007, Pages 765-782

  Saywell, S A ^a   Anissimova, N P ^a   Ford, T W ^a   Meehan, C F ^a   Kirkwood, P A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAT; CELL REGENERATION; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; INTERNEURON; INTRACELLULAR RECORDING; MALE; NERVE CELL PLASTICITY; NERVE POTENTIAL; NERVE PROJECTION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; RESPIRATION CONTROL; RESPIRATORY DRIVE; SPINAL CORD MOTONEURON; TARGET ORGAN; THORACIC SPINAL CORD; ACTION POTENTIAL AMPLITUDE; ANIMAL TISSUE; CAUDAL MEDULLA; EXPIRATORY BULBOSPINAL NERVE CELL; MEDULLA OBLONGATA; MONOSYNAPTIC POTENTIAL; MOTONEURON; NERVE CELL MEMBRANE STEADY POTENTIAL; SPINAL CORD NERVE CELL;

ACTION POTENTIALS; ANIMALS; CATS; EFFERENT PATHWAYS; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; EXHALATION; FEMALE; INHALATION; INTERCOSTAL NERVES; MALE; MOTOR NEURONS; RESPIRATORY CENTER;

EID: 33947186762     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.122481     Document Type: Article

References (53)

1. Anissimova NP, Saywell SA, Ford TW & Kirkwood PA (2001). Distributions of EPSPs from individual expiratory bulbospinal neurones in the normal and the chronically lesioned thoracic spinal cord. XXXIV Congress of the International Union of Physiological Sciences Abstract 1029.
2. Appenteng K, O'Donovan MJ, Somjen G, Stephens JA & Taylor A (1978). The projection of jaw elevator muscle spindle afferents to fifth nerve motoneurones in the cat. J Physiol 279, 409-432.
3. Boers J, Kirkwood P, De Weerd H & Holstege G (2006). Ultrastructural evidence for direct excitatory retroambiguus projections to cutaneus trunci and abdominal muscle motoneurons in the cat. Brain Res Bull 68, 249-256.
4. Cohen MI, Feldman JL & Sommer D (1985). Caudal medullary expiratory neuron and internal intercostal nerve discharges in the cat: Effects of lung inflation. J Physiol 368, 147-178.
5. Davies JGMcF, Kirkwood PA & Sears TA (1985 a). The detection of monosynaptic connexions from inspiratory bulbospinal neurones to inspiratory motoneurones in the cat. J Physiol 368, 33-62.
6. Davies JGMcF, Kirkwood PA & Sears TA (1985 b). The distribution of monosynaptic connexions from inspiratory bulbospinal neurones to inspiratory motoneurones in the cat. J Physiol 368, 63-87.
7. De Troyer A, Kirkwood PA & Wilson TA (2005). Respiratory action of the intercostal muscles. Physiol Rev 85, 717-756.
8. Enríquez Denton M, Kirkwood PA, Wienecke J & Hultborn HR (2003). Do respiratory motoneurons need plateau potentials? Abstract Viewer/Itinerary Planner, Society for Neuroscience, Washington, DC; Program No. 496.13.2003.
9. Feldman JL, Sommer D & Cohen MI (1980). Short time scale correlations between discharges of medullary respiratory neurons. J Neurophysiol 43, 1284-1295.
10. Fleshman JW, Munson JB & Sypert GW (1981). Homonymous projection of individual group Ia-fibers to physiologically characterized medial gastrocnemius motoneurons in the cat. J Neurophysiol 46, 1339-1348.
11. Ford TW & Kirkwood PA (2006). Respiratory drive in hindlimb motoneurones of the anaesthetized female cat. Brain Res Bull 70, 450-456.
12. Ford TW, McWilliam PN & Shepheard SL (1987). A multibarrelled platinum-coated micro-elecrode. J Physiol 386, 9 P.
13. Ford TW, Saywell SA & Kirkwood PA (1999). Relationship between single-fibre EPSPs and respiratory drive potentials in expiratory motoneurones. J Physiol 518.P, 69 P.
14. Ford TW, Vaughan CW & Kirkwood PA (2000). Changes in the distribution of synaptic potentials from bulbospinal neurones following axotomy in cat thoracic spinal cord. J Physiol 524, 163-178.
15. Graham K & Duffin J (1981). Cross correlation of medullary expiratory neurons in the cat. Exp Neurol 73, 451-464.
16. Harrison PJ & Taylor A (1981). Individual excitatory post-synaptic potentials due to muscle spindle Ia afferents in cat triceps surae motoneurones. J Physiol 312, 455-470.
17. Heckman CJ, Gorassini MA & Bennett DJ (2005). Persistent inward currents in motoneuron dendrites: Implications for motor output. Muscle Nerve 31, 135-156.
18. Henneman E, Somjen G & Carpenter DO (1965). Functional significance of cell size in spinal motoneurons. J Neurophysiol 28, 560-580.
19. Hilaire GG, Nicholls JG & Sears TA (1983). Central and proprioceptive influences on the activity of levator costae motoneurones in the cat. J Physiol 342, 527-548.
20. Hultborn H (1999). Plateau potentials and their role in regulating motoneuronal firing. Prog Brain Res 123, 39-48.
21. Jack JJB, Miller S, Porter R & Redman SJ (1971). The time course of minimal excitatory post-synaptic potentials evoked in spinal motoneurones by group Ia afferent fibres. J Physiol 215, 353-380.
22. Kirkwood PA (1995). Synaptic excitation in the thoracic spinal cord from expiratory bulbospinal neurons in the cat. J Physiol 484, 201-225.
23. Kirkwood P, Enríquez Denton M, Wienecke J, Nielsen JB & Hultborn H (2005). Physiological roles for persistent inward currents in motoneurones: Insights from the central respiratory drive. Biocybernet Biomed Eng 38, 31-38.
24. Kirkwood PA & Ford TW (2004). Do respiratory neurons control female receptive behavior: A suggested role for a medullary central pattern generator? Prog Brain Res 143, 105-114.
25. Kirkwood PA, Ford TW, Donga R, Saywell SA & Holstege G (1999). Assessing the strengths of motoneuron inputs: Different anatomical and physiological approaches compared. Prog Brain Res 123, 67-82.
26. Kirkwood PA, Lawton M & Ford TW (2002). Plateau potentials in hindlimb motoneurones of female cats under anaesthesia. Exp Brain Res 146, 399-403.
27. Kirkwood PA, Munson JB, Sears TA & Westgaard RH (1988). Respiratory interneurones in the thoracic spinal cord of the cat. J Physiol 395, 161-192.
28. Kirkwood PA & Road JD (1995). On the functional significance of long monosynaptic descending pathways to spinal motoneurones. In Alpha and Gamma Motor Systems, ed. Taylor A, Gladden MH & Durbaba R, pp. 589-592. Plenum Press, London.
29. Kirkwood PA, Schmid K & Sears TA (1993). Functional identities of thoracic respiratory interneurones in the cat. J Physiol 461, 667-687.
30. Kirkwood PA & Sears TA (1973). Monosynaptic excitation of thoracic expiratory motoneurones from lateral respiratory neurones in the medulla of the cat. J Physiol 234, 87-89 P.
31. Kirkwood PA & Sears TA (1978). The synaptic connexions to intercostal motoneurones as revealed by the average common excitation potential. J Physiol 275, 103-134.
32. Kirkwood PA & Sears TA (1982). Excitatory post-synaptic potentials from single muscle spindle afferents in external intercostal motoneurones of the cat. J Physiol 322, 287-314.
33. Kirkwood PA & Sears TA (1991). Cross-correlation analyses of motoneurone inputs in a coordinated motor act. In Neuronal Cooperativity, ed. Kruger J, pp. 225-248. Springer-Verlag, Berlin.
34. Kirkwood PA, Sears TA, Tuck DL & Westgaard RH (1982). Variations in the time course of the synchronization of intercostal motoneurones in the cat. J Physiol 327, 105-135.
35. Lipski J & Martin-Body RL (1987). Morphological properties of respiratory intercostal motoneurons in cats as revealed by intracellular injection of horseradish peroxidase. J Comp Neurol 260, 423-434.
36. Meehan CF, Ford TW, Road JD, Donga R, Saywell SA, Anissimova NP & Kirkwood PA (2004). The rostro-caudal distribution of motoneurones and the variation in ventral horn area within a segment of the feline thoracic spinal cord. J Comp Neurol 472, 281-291.
37. Merrill EG (1970). The lateral respiratory neurones of the medulla: their associations with nucleus ambiguus, nucleus retroambigualis, the spinal accessory nucleus and the spinal cord. Brain Res 24, 11-28.
38. Merrill EG & Lipski J (1987). Inputs to intercostal motoneurons from ventrolateral medullary respiratory neurons in the cat. J Neurophysiol 57, 1837-1853.
39. Monteau R & Hilaire G (1991). Spinal respiratory motoneurons. Progr Neurobiol 37, 83-141.
40. Monteau R, Khatib M & Hilaire G (1985). Central determination of recruitment order: Intracellular study of phrenic motoneurons. Neurosci Lett 56, 341-346.
41. Munson JB, Sypert GW, Zengel JE, Lofton SA & Fleshman JW (1982). Monosynaptic projections of individual spindle group II afferents to type-identified medial gastrocnemius motoneurons in the cat. J Neurophysiol 48, 1164-1174.
42. Rall W (1967). Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J Neurophysiol 30, 1138-1168.
43. Saywell SA, Ford TW & Kirkwood PA (1998). Morphology and projections of thoracic interneurones. J Physiol 509.P, 170 P.
44. Saywell SA, Ford TW & Kirkwood PA (1999). Reinvestigation of connections from expiratory bulbospinal neurones to thoracic motoneurones. J Physiol 518.P, 68 P.
45. Scott JG & Mendell LM (1976). Individual EPSPs produced by single triceps surae Ia afferents in homonymous and heteronymous motoneurons. J Neurophysiol 39, 679-692.
46. Sears TA (1964 a). The fibre calibre spectra of sensory and motor fibres in the intercostal nerves of the cat. J Physiol 172, 150-161.
47. Sears TA (1964 b). The slow potentials of thoracic respiratory motoneurones and their relation to breathing. J Physiol 175, 404-424.
48. Sears TA (1977). The respiratory motoneuron and apneusis. Fed Proc 36, 2412-2420.
49. Tani M, Kida MY & Akita K (1994). Relationship between the arrangement of motoneuron pools in the ventral horn and ramification pattern of the spinal nerve innervating trunk muscles in the cat (Felis domestica). Exp Neurol 128, 290-300.
50. Taylor A (1960). The contribution of the intercostal muscles to the effort of respiration in man. J Physiol 151, 390-402.
51. VanderHorst VGJM, de Weerd H & Holstege G (1997). Evidence for monosynaptic projections from the nucleus retroambiguus to hindlimb motoneurons in the cat. Neurosci Lett 224, 33-36.
52. VanderHorst VGJM, Terasawa E, Ralston HJ 3rd & Holstege G (2000). Monosynaptic projections from the nucleus retroambiguus to motoneurons supplying the abdominal wall, axial, hindlimb, and pelvic floor in the female rhesus monkey. J Comp Neurol 424, 233-250.
53. Vaughan CW & Kirkwood PA (1997). Evidence from motoneurone synchronization for disynaptic pathways in the control of inspiratory motoneurones in the cat. J Physiol 503, 673-691.