The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6′-N-acetyltransferase and the role of 6′-NH2 in antibacterial activity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 2944-2951

  Yan, Xuxu ^a   Gao, Feng ^a   Yotphan, Sirilata ^a   Bakirtzian, Parseh ^a   Auclair, Karine ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

A site; Acetyltransferase; Aminoglycoside; Antibacterial; Antibiotic; Neamine; Regioselective; Resistance; RNA

Indexed keywords

ACYLTRANSFERASE; AMINOGLYCOSIDE DERIVATIVE; RIBOSOME RNA;

ACYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR PROBE;

ACETYLTRANSFERASES; AMINES; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIA; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; HYDROGEN BONDING; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; RNA, RIBOSOMAL, 16S; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947176697     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.009     Document Type: Article

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