Mothball withdrawal encephalopathy - Case report and review of paradichlorobenzene neurotoxicity

Substance Abuse

Volumn 27, Issue 4, 2007, Pages 63-67

  Cheong, Raymond ^a   Wilson, Robin K ^a   Cortese, Irene C M ^a   Newman Toker, David E ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

2 dichlorobenzene; Basal ganglia diseases; Catatonia; Neurotoxicity syndromes; Substance withdrawal syndrome; Substance related disorders

Indexed keywords

1,4 DICHLOROBENZENE; 2,5 DICHLOROPHENOL; ANTIDEPRESSANT AGENT; BENZODIAZEPINE; CARBIDOPA PLUS LEVODOPA; METHYLPHENIDATE; NEUROLEPTIC AGENT;

ADULT; ANAMNESIS; ARTICLE; BRAIN DISEASE; CASE REPORT; CEREBELLUM DISEASE; CEREBROSPINAL FLUID ANALYSIS; CLINICAL FEATURE; COGNITIVE DEFECT; ELECTROENCEPHALOGRAM; ELECTROMYOGRAPHY; EXTRAPYRAMIDAL SYNDROME; FEMALE; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; INGESTION; MAJOR DEPRESSION; NEUROLOGIC EXAMINATION; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PYRAMIDAL SIGN; REHABILITATION CENTER; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STOMACH TUBE; WITHDRAWAL SYNDROME;

ADMINISTRATION, ORAL; ADULT; CHLOROBENZENES; CHLOROPHENOLS; DIAGNOSIS, DIFFERENTIAL; FEMALE; FOLLOW-UP STUDIES; GAIT ATAXIA; HUMANS; INSECTICIDES; MUTISM; NEUROLOGIC EXAMINATION; NEUROMUSCULAR DISEASES; NEUROTOXICITY SYNDROMES; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 33947171080     PISSN: 08897077     EISSN: 15470164     Source Type: Journal    
DOI: 10.1300/J465v27n04_08     Document Type: Article

References (9)

1. Siegel E, Wason S: Mothball toxicity. Pediatr Clin North Am 1986; 33:369-74.
2. Reygagne A, Garnier R, Chataigner D, Echenne B, Efthymiou ML: Encephalopathy caused by repeated voluntary inhalation of paradichlorobenzene (translated). Presse Med 1992; 21:267.
3. Weintraub E, Gandhi D, Robinson C: Medical complications due to mothball abuse. South Med J 2000; 93:427-9.
4. Avila E, Schraeder P, Belliappa A, Faro S: Pica with paradichlorobenzene mothball ingestion associated with toxic leukoencephalopathy. J Neuroimaging 2006; 16:78-81.
5. Frank SB, Cohen HJ: Fixed drug eruption due to paradichlorobenzene. N Y State J Med 1961; 61:4079.
6. Miyai I, Hirono N, Fujita M, Kameyama M: Reversible ataxia following chronic exposure to paradichlorobenzene. J Neurol Neurosurg Psychiatry 1988; 51:453-4.
7. Bomhard EM, Schmidt U, Loser E: Time course of enzyme induction in liver and kidneys and absorption, distribution and elimination of 1,4-dichlorobenzene in rats. Toxicology 1998; 131:73-91.
8. Yoshida T, Andoh K, Kosaka H, Kumagai S, Matsunaga I, Akasaka S, Nakamura S, Oda H, Fukuhara M: Inhalation toxicokinetics of p-dichlorobenzene and daily absorption and internal accumulation in chronic low-level exposure to humans. Arch Toxicol 2002; 76: 306-15.
9. Phillips SC, Cragg BG: Alcohol withdrawal causes a loss of cerebellar Purkinje cells in mice. J Stud Alcohol 1984; 45:475-80.