High-performance liquid chromatography-electrospray ionization-mass spectrometric determination of emedastine difumarate in human plasma and its pharmacokinetics

Journal of Chromatographic Science

Volumn 45, Issue 3, 2007, Pages 158-164

  Tian, Yuan ^a   Zhang, Zunjian ^a   Liang, Jiabi ^a   Li, Wei ^a   Chen, Yun ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33947157163     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/45.3.158     Document Type: Article

References (7)

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2. T. Saito, N. Nishimura, S. Tajima, T. Fukuda, and K. Ito. Anti-allergic effects of 1-(2-ethoxyethyl)-(4-methyl-1-homopiperazinyl)-benzimidazole difumarate (KB-2413). Nippon Yakurigaku Zasshi 89: 55-62 (1987).
3. 1-blockers on neuropharmacological and behavioral effects including 1-(2-ethoxyethyl)-(4- methyl-1-homopiperazinyl)-benzimidazole difumarate (KB-2413). Arch. Iternat. Pharmacodynam. 280: 275-91 (1986).
4. 1-receptor antagonist emedastine in healthy volunteers. Eur. J. Clin. Pharmacol. 55: 837-41 (2000).
5. 14C-labelled emedastine difumarate in healthy volunteers. Taylor & Francis Health Sci. 32: 761-70 (2002).
6. C. Joukhadar, U. Herranz, T. Pernersoyrfer, A. Asssandri, N. Klein, C. Schrolnberger, E. Lackner, Hans G. Eichler, and M. Müller. Pharmacokinetics of emedastine difumarate, a New Anti-histaminic agent in patients with renal impairment. Eur. J. Clin. Pharmacol. 56: 905-10 (2001).
7. T. Hamada, M. Kadowaki, Y. Nakamura, and N. Awata. Determination of the Antiallergic Agent KB-2413 in plasma by means of capillary gas chromatography with a nitrogen-sensitive detector. Chem. Pharm. Bull. 34: 1168-71 (1986).