Evidence for existence of cAMP-Epac signaling in the heads of mouse epididymal spermatozoa

Journal of Reproduction and Development

Volumn 53, Issue 1, 2007, Pages 127-133

  Amano, Reiko ^a   Lee, Jibak ^a,b   Goto, Namiko ^a   Harayama, Hiroshi ^a  

^a KOBE UNIVERSITY   (Japan)

^b Center for Frontier Research in Medicinal Science   (Japan)

Author keywords

5 monophosphate (cAMP); Cyclic adenosine 3 ; Exchange protein directly activated by cAMP (Epac); Intracellular signaling; Mouse; Rap1; Sperm

Indexed keywords

5730402K07RIK PROTEIN, MOUSE; CARRIER PROTEIN; CYCLIC AMP; EPAC PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; RAP1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CYTOLOGY; EPIDIDYMIS; GENETICS; IN SITU HYBRIDIZATION; MALE; METABOLISM; MOUSE; NORTHERN BLOTTING; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPERMATOZOON;

ANIMALS; BLOTTING, NORTHERN; CARRIER PROTEINS; CYCLIC AMP; EPIDIDYMIS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; IN SITU HYBRIDIZATION; MALE; MICE; RAP1 GTP-BINDING PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPERM HEAD;

MAMMALIA;

EID: 33947143017     PISSN: 09168818     EISSN: 13484400     Source Type: Journal    
DOI: 10.1262/jrd.18077     Document Type: Article

References (15)

1. Beavo JA, Brunton LL. Cyclic nucleotide research - still expanding after half a century. Nat Rev Mol Cell Biol 2002; 3: 710-718.
2. Yogo K, Ogawa T, Akiyama M, Ishida-Kitagawa N, Sasada H, Sato E, Takeya T. PKA implicated in the phosphorylation of Cx43 induced by stimulation with FSH in rat granulosa cells. J Reprod Dev 2006; 52: 321-328.
3. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 1998; 396: 474-477.
4. Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 2003; 4: 733-738.
5. Bos JL, de Bruyn K, Enserink J, Kuiperij B, Rangarajan S, Rehmann H, Riedl J, de Rooij J, van Mansfeld F, Zwartkruis F. The role of Rap1 in integrin-mediated cell adhesion. Biochem Soc Trans 2003; 31: 83-86.
6. Visconti PE, Kopf GS. Regulation of protein phosphorylation during sperm capacitation. Biol Reprod 1998; 59: 1-6.
7. Breitbart H. Intracellular calcium regulation in sperm capacitation and acrosomal reaction. Mol Cell Endocrinol 2002; 187: 139-144.
8. Urner F, Sakkas D. Protein phosphorylation in mammalian spermatozoa. Reproduction 2003; 125: 17-26.
9. Fraser LR, Adeoya-Osiguwa S, Baxendale RW, Mededovic S, Osiguwa OO. First messenger regulation of mammalian sperm function via adenylyl cyclase/cAMP. J Reprod Dev 2005; 51: 37-46.
10. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature 2001; 413: 603-609.
11. Branham MT, Mayorga LS, Tomes CN. Calcium-induced acrosomal exocytosis requires cAMP acting through a protein kinase A-independent, Epac-mediated pathway. J Biol Chem 2006; 281: 8656-8666.
12. Kinukawa M, Oda S, Shirakura Y, Okabe M, Ohmuro J, Baba SA, Nagata M, Aoki F. Roles of cAMP in regulating microtubule sliding and flagellar bending in demembranated hamster spermatozoa. FEBS Lett 2006; 580: 1515-1520.
13. Lee J, Iwai T, Yokota T, Yamashita M. Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci 2003; 116: 2781-2790.
14. Guan KL, Dixon JE. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem 1991; 192: 262-267.
15. Quinn P, Kerin JF, Warnes GM. Improved pregnancy rate in human in vitro fertilization with the use of a medium based on the composition of human tubal fluid. Fertil Steril 1985; 44: 493-498.