Activation of MAPK in fibroblasts by Treponema denticola major outer sheath protein

Biochemical and Biophysical Research Communications

Volumn 356, Issue 1, 2007, Pages 213-218

  Jobin, Marie Claude ^a   Virdee, Inderpreet ^a   McCulloch, Christopher A ^a   Ellen, Richard P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

ERK 1 2; Fibroblasts; Kinase proteome; MAPK phosphorylation; Msp; p38; Pore forming toxin; Treponema denticola

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIN; CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OUTER MEMBRANE PROTEIN; U 1026; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL LYSATE; DENSITOMETRY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; RAT; STRESS; TREPONEMA DENTICOLA;

ANIMALS; BACTERIAL PROTEINS; BUTADIENES; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FIBROBLASTS; IMIDAZOLES; IMMUNOBLOTTING; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PORINS; PROTEIN KINASES; PYRIDINES; RATS; TIME FACTORS;

TREPONEMA DENTICOLA;

EID: 33947142352     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.02.111     Document Type: Article

References (26)

1. Ellen R.P., and Galimanas V.B. Spirochetes at the forefront of periodontal infections. Periodontol. 2000 38 (2005) 13-32
2. Yang P.F., Song M., Grove D.A., and Ellen R.P. Filamentous actin disruption and diminished inositol phosphate response in gingival fibroblasts caused by Treponema denticola. Infect. Immun. 66 (1998) 696-702
3. Amin M., Ho A.C., Lin J.Y., Batista da Silva A.P., Glogauer M., and Ellen R.P. Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein. Infect. Immun. 72 (2004) 3650-3654
4. Baehni P.C., Song M., McCulloch C.A., and Ellen R.P. Treponema denticola induces actin rearrangement and detachment of human gingival fibroblasts. Infect. Immun. 60 (1992) 3360-3368
5. Batista da Silva A.P., Lee W., Bajenova E., McCulloch C.A., and Ellen R.P. The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts. Cell. Microbiol. 6 (2004) 485-498
6. Wang Q., Ko K.S., Kapus A., McCulloch C.A., and Ellen R.P. A spirochete surface protein uncouples store-operated calcium channels in fibroblasts: a novel cytotoxic mechanism. J. Biol. Chem. 276 (2001) 23056-23064
7. Egli C., Leung W.K., Müller K.H., Hancock R.E., and McBride B.C. Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola. Infect. Immun. 61 (1993) 1694-1699
8. Mathers D.A., Leung W.K., Fenno J.C., Hong Y., and McBride B.C. The major surface protein complex of Treponema denticola depolarizes and induces ion channels in HeLa cell membranes. Infect. Immun. 64 (1996) 2904-2910
9. Galdiero M., Vitiello M., Sanzari E., D'Isanto M., Tortora A., Longanella A., and Galdiero S. Porins from Salmonella enterica serovar Typhimurium activate the transcription factors activating protein 1 and NF-κB through the Raf-1-mitogen-activated protein kinase cascade. Infect. Immun. 70 (2002) 558-568
10. Pichon S., Bryckaert M., and Berrou E. Control of actin dynamics by p38 MAP kinase-Hsp27 distribution in the lamellipodium of smooth muscle cells. J. Cell Sci. 117 (2004) 2569-2577
11. Sukezane T., Oneyama C., Kakumoto K., Shibutani K., Hanafusa H., and Akagi T. Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras. Oncogene 24 (2005) 5648-5655
12. Arora P.D., Bibby K.J., and McCulloch C.A. Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch. J. Cell Physiol. 161 (1994) 187-200
13. Ko K.S., Glogauer M., McCulloch C.A., and Ellen R.P. Treponema denticola outer membrane inhibits calcium flux in gingival fibroblasts. Infect. Immun. 66 (1998) 703-709
14. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
15. Abramoff M.D., Magelhaes P.J., and Ram S.J. Image Processing with ImageJ. Biophoton. Int. 11 (2004) 36-42
16. Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179
17. dos Remedios C.G., Chhabra D., Kekic M., Dedova I.V., Tsubakihara M., Berry D.A., and Nosworthy N.J. Actin binding proteins: regulation of cytoskeletal microfilaments. Physiol. Rev. 83 (2003) 433-473
18. Steele-Mortimer O., Knodler L.A., and Finlay B.B. Poisons, ruffles and rockets: bacterial pathogens and the host cell cytoskeleton. Traffic 1 (2000) 107-118
19. Gruenheid S., and Finlay B.B. Microbial pathogenesis and cytoskeletal function. Nature 422 (2003) 775-781
20. Garcia J.G., Wang P., Schaphorst K.L., Becker P.M., Borbiev T., Liu F., Birukova A., Jacobs K., Bogatcheva N., and Verin A.D. Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. FASEB J. 16 (2002) 1064-1076
21. 2+-induced cell death in a caspase-dependent and -independent manner in rat retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 46 (2005) 1085-1091
22. Fenno J.C., Hannam P.M., Leung W.K., Tamura M., Uitto V.J., and McBride B.C. Cytopathic effects of the major surface protein and the chymotrypsinlike protease of Treponema denticola. Infect. Immun. 66 (1998) 1869-1877
23. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 (2000) 95-105
24. Leung W.K., Wu Q., Hannam P.M., McBride B.C., and Uitto V.J. Treponema denticola may stimulate both epithelial proliferation and apoptosis through MAP kinase signal pathways. J. Periodont. Res. 37 (2002) 445-455
25. Ratner A.J., Hippe K.R., Aguilar J.L., Bender M.H., Nelson A.L., and Weiser J.N. Epithelial cells are sensitive detectors of bacterial pore-forming toxins. J. Biol. Chem. 281 (2006) 12994-12998
26. Roux P.P., and Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68 (2004) 320-344