Prevention of CCl4-induced liver damage by ginger, garlic and vitamin E

Pakistan Journal of Biological Sciences

Volumn 10, Issue 4, 2007, Pages 617-621

  Patrick Iwuanyanwu, K C ^a   Wegwu, M O ^a   Ayalogu, E O ^a  

^a UNIVERSITY OF PORT HARCOURT   (Nigeria)

Author keywords

Biochemical parameters; Carbon tetrachloride; Histological examination; Lipid peroxidation; Malondialdehyde; Pre treatment

Indexed keywords

ALLIUM SATIVUM; ANIMALIA; RATTUS; ZINGIBER OFFICINALE;

ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; CARBON TETRACHLORIDE; MALONALDEHYDE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; ENZYMOLOGY; GARLIC; GINGER; LIVER DISEASE; MALE; METABOLISM; PATHOLOGY; RAT; WISTAR RAT;

ALKALINE PHOSPHATASE; ANIMALS; CARBON TETRACHLORIDE; GARLIC; GINGER; LIVER DISEASES; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR; VITAMIN E;

EID: 33947138716     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2007.617.621     Document Type: Article

References (23)

1. Ahmed, R.S. and S.B. Sharma, 1997. Biochemical studies on combined effects of garlic (Allium sativum Linn) and ginger (Zingiber officinale Rosc) in albino rats. Indian J. Exp. Biol. 35: 841-843.
2. Albano, E., G. Bellorno, R. Carini, F. Biasi, G. Poli and M.U. Dianzani, 1985. Mechanisms responsible for carbon tetrachloride-induced perturbation of mitochondrial calcium homeostasis. FEBS Lett., 192: 184-188.
3. Artizzu, M. and M.U. Dianzani, 1962. The changes in the mitochondria lysosomes in the fatty livers of rats fed with carbon tetrachloride and their independence of ribonuclease activation. Biochem. Biophys. Acta, 63: 453-464.
4. Brattin, W.J., S.D. Pencil, R.L. Waller, E.A. Glende and O. Recknagel, 1984. Assessment of the role of calcium ion in halocarbon hepatotoxicity. Environ. Health Perspect, 57: 321-323.
5. Dianzani, M.U., 1991. Biochemical Aspects of Fatty Liver. In: Hepatotoxicology. Meeks, R.G., S.D. Harrison and R.J. Bull (Eds.), CRC Press, Boca Raton, FL, pp: 327-399.
6. Gutteridge, J.M.C. and C. Wilkins, 1980. Copper dependent hydroxyl radical damage to ascorbic acid formation of a thiobarbituric acid reactive products. FEBS. Lett., 137: 327-340.
7. Hukkeri, V.I., B. Jaiprakash, M.S. Lavhale, R.V. Karadi and I.J. Kuppast, 2002. Hepatoprotective activity of Anthus excelsa Roxb. leaf extracts on experimental liver damage in rats. J. Pharmacogn., 11: 120-128.
8. Hunter, F.E., J.M. Gebicki, P.E. Hoffstein, J. Weinstein and A. Scott, 1963. Swelling and lysis of rats liver mitochondria induced by ferrous ions. J. Biol. Chem., 238: 828-835.
9. 4 in cultural rat hepatocytes. Pharmacol. Toxicol., 83: 231-239.
10. Junnila, M., T. Rahko, A. Sukura and L.A. Lindberg, 2000. Reduction of carbon tetrachloride induced hepatotoxic effects by oral administration of betaine in male Hans-Wistar rats: A morphometric Histological study. Vet. Pathol., 37: 231-238.
11. Koji, H., K. Shigotoghi, B. Purusotam and N. Tsuneo, 1966. Hepatoprotective effectes of traditional medicines isolation of the active constituent from seeds of C. argentea. Psychother. Res., 10: 387-382.
12. Lin, J.K. and C.J. Wang, 1986. Protection of Crocin dyes in the acute hepatic damage induced by Aflatoxin B and dimethylnitrosamine in rats. Carcinogenis, 7: 595-599.
13. Mustafa, T. and K.C. Srivastava, 1990. Ginger (Zingiber officinale) in Migraine headache. J. Ethnopharmacol., 29: 267-273.
14. Ngaha, E.O., Akanji, M.A. and M.A. Madusolumuo, 1989. Studies on correlation between chloroquine-induced tissue damage and serum enzyme changes in the rat. Experientia, 45: 143-146.
15. Obi, F.O., I.A. Usenu and J.O. Osayande, 1998. Prevention of carbon tetrachloride-induced hepatotoxicity in the rat by H. rosasinensis anthocyanin extract administered methanol. J. Toxicol., 131: 93-98
16. Obi, F.O., L.A. Omogbai, O.S.J. Oriafo, O.D. Ovat, 2001. Effect of a short time post carbon tetrachloride treatment interval on rat plasma enzyme levels and percentage mortality. J. Applied Sci. Environ. Mgt., 5: 5-8.
17. Poli, G., E. Albano and M.U. Dianzani, 1987. The role of lipid peroxidation in liver damage. Chem. Phys. Lipids, 45: 117-142.
18. Raghavendran, B.R.H., A. Sathivel and T. Devaki, 2003. Hepatoprotective Nature of seaweed alcoholic extract on Acetaminophen induced oxidative stress. J. Health Sci., 50: 42-46.
19. Recknagel, R.O., 1967. Carbon tetrachloride hepatotoxicity. Pharmacol. Rev., 19: 145-208.
20. Reynolds, E.S., R.E. Thiers and B.L. Vallee, 1962. Mitochondrial function and metal content in carbontetrachloride poisoning. J. Biol. Chem., 237: 3546-3551.
21. 4-induced hepatic injury in rats. Indian J. Pharmacol., 33: 260-266.
22. Sieger, C.P., W. Horn and M. Younes, 1985. Effect of hypoxia on the metabolism and hepatotoxicity of carbon tetrachloride and vinylidene chloride in rats. Acta Pharmacol. Toxicol., 56: 81-86.
23. Zar, J.H., 1984. Biostatistical analysis. Prentice Hall. Englewood Cliffs, N.J. USA.