Role of homologous ASP334 and GLU319 in human non-gastric H,K- and Na,K-ATPases in cardiac glycoside binding

Biochemical and Biophysical Research Communications

Volumn 356, Issue 1, 2007, Pages 142-146

  Radkov, Rossen ^a   Kharoubi Hess, Solange ^b   Schaer, Danièle ^b   Modyanov, Nikolai N ^a   Geering, Käthi ^b   Horisberger, Jean Daniel ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Cardiac glycoside; Cardiac steroid; H,K ATPase; Na,K ATPase; Ouabain affinity; Site directed mutagenesis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ASPARTIC ACID; CARDIAC GLYCOSIDE; GLUTAMIC ACID; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; OUABAGENIN; OUABAIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME INHIBITION; FROG; IC 50; ION TRANSPORT; MUTATION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CARDIAC GLYCOSIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; GLUTAMIC ACID; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; MEMBRANE POTENTIALS; MUTATION; NA(+)-K(+)-EXCHANGING ATPASE; OOCYTES; OUABAIN; PROTEIN SUBUNITS; RABBITS; RATS; RUBIDIUM RADIOISOTOPES; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

RATTUS; STROPHANTHUS GRATUS;

EID: 33947130614     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.02.119     Document Type: Article

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