Randomized trial of a single repeat dose of prenatal betamethasone treatment in imminent preterm birth

Pediatrics

Volumn 119, Issue 2, 2007, Pages 290-298

  Peltoniemi, Outi M ^a   Kari, M Anneli ^b   Tammela, Outi ^c   Lehtonen, Liisa ^d   Marttila, Riitta ^e   Halmesmäki, Erja ^f   Jouppila, Pentti ^a   Hallman, Mikko ^a  

^a UNIVERSITY OF OULU   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

^e SEINÄJOKI CENTRAL HOSPITAL   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Intraventricular hemorrhage; Premature birth; Premature infant; Prenatal corticosteroid; Prenatal glucocorticoid; Respiratory distress syndrome

Indexed keywords

BETAMETHASONE; PLACEBO; SURFACTANT;

ADULT; ARTICLE; BRAIN HEMORRHAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GESTATION PERIOD; GESTATIONAL AGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; PREMATURE LABOR; PRENATAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS SYNDROME; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SURVIVAL; SURVIVAL RATE; TREATMENT OUTCOME;

BETAMETHASONE; FEMALE; GLUCOCORTICOIDS; HUMANS; INFANT, NEWBORN; INTRACRANIAL HEMORRHAGES; MALE; PREMATURE BIRTH; PRENATAL CARE; RESPIRATORY DISTRESS SYNDROME, NEWBORN; SINGLE-BLIND METHOD;

EID: 33947123104     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2006-1549     Document Type: Article

References (41)

1. Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics. 1972;50:515-525
2. Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev. 2000;(2):CD000065
3. National Institutes of Health Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA. 1995;273:413-418
4. Ikegami M, Polk D, Jobe A. Minimum interval from fetal betamethasone treatment to postnatal lung responses in preterm lambs. Am J Obstet Gynecol. 1996;174:1408-1413
5. Wright LL, Verter J, Younes N, et al. Antenatal corticosteroid administration and neonatal outcome in very low birth weight infants: the NICHD Neonatal Research Network. Am J Obstet Gynecol. 1995;173:269-274
6. Elimian A, Figueroa R, Spitzer AR, et al. Antenatal corticosteroids: are incomplete courses beneficial? Obstet Gynecol. 2003;102:352-355
7. Polk DH, Ikegami M, Jobe AH, et al. Preterm lung function after retreatment with antenatal betamethasone in preterm lambs. Am J Obstet Gynecol. 1997;176:308-315
8. Vermillion ST, Soper DE, Newman RB. Is betamethasone effective longer than 7 days after treatment? Obstet Gynecol. 2001;97:491-493
9. Banks BA, Cnaan A, Morgan MA, et al. Multiple courses of antenatal corticosteroids and outcome of premature neonates: North American Thyrotropin-Releasing Hormone Study Group. Am J Obstet Gynecol. 1999;181:709-717
10. Abbasi S, Hirsch D, Davis J, et al. Effect of single versus multiple courses of antenatal corticosteroids on maternal and neonatal outcome. Am J Obstet Gynecol. 2000;182:1243-1249
11. Sehdev HM, Abbasi S, Robertson P, et al. The effects of the time interval from antenatal corticosteroid exposure to delivery on neonatal outcome of very low birth weight infants. Am J Obstet Gynecol. 2004;191:1409-1413
12. Garite TJ, Rumney PJ, Briggs GG, et al. A randomized, placebo-controlled trial of betamethasone for the prevention of respiratory distress syndrome at 24 to 28 weeks' gestation. Am J Obstet Gynecol. 1992;166:646-651
13. Chapman SJ, Hauth JC, Bottoms SF, et al. Benefits of maternal corticosteroid therapy in infants weighing ≤1000 grams at birth after preterm rupture of the amnion. Am J Obstet Gynecol. 1999;180:677-682
14. Guinn DA, Atkinson MW, Sullivan L, et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. JAMA. 2001;286:1581-1587
15. McEvoy C, Bowling S, Williamson K, et al. The effect of a single remote course versus weekly courses of antenatal corticosteroids on functional residual capacity in preterm infants: a randomized trial. Pediatrics. 2002;110:280-284
16. Vermillion ST, Bland ML, Soper DE. Effectiveness of a rescue dose of antenatal betamethasone after an initial single course. Am J Obstet Gynecol. 2001;185:1086-1089
17. Vermillion ST, Soper DE, Newman RB. Neonatal sepsis and death after multiple courses of antenatal betamethasone therapy. Am J Obstet Gynecol. 2000;183:810-814
18. Bloom SL, Sheffield JS, McIntire DD, Leveno KJ. Antenatal dexamethasone and decreased birth weight. Obstet Gynecol. 2001;97:485-490
19. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529-534
20. de Vries LS, Eken P, Dubowitz LM. The spectrum of leukomalacia using cranial ultrasound. Behav Brain Res. 1992;49:1-6
21. Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1-7
22. Kari MA, Hallman M, Eronen M, et al. Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: a randomized placebo-controlled multicenter study. Pediatrics. 1994;93:730-736
23. Schutte MF, Treffers PE, Koppe JG, Breur W. The influence of betamethasone and orciprenaline on the incidence of respiratory distress syndrome in the newborn after preterm labour. Br J Obstet Gynaecol. 1980;87:127-131
24. Ikegami M, Jobe AH, Newnham J, et al. Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med. 1997;156:178-184
25. 4 acetylation. J Immunol. 2005;175:478-486
26. Kallapur SG, Kramer BW, Moss TJ, et al. Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs. Am J Physiol Lung Cell Mol Physiol. 2003;284:L633-L642
27. Ng PC, Wong GW, Lam CW, et al. Pituitary-adrenal response in preterm very low birth weight infants after treatment with antenatal corticosteroids. J Clin Endocrinol Metab. 1997;82:3548-3552
28. Arnold JD, Bonacruz G, Leslie GI, et al. Antenatal glucocorticoids modulate the amplitude of pulsatile cortisol secretion in premature neonates. Pediatr Res. 1998;44:876-881
29. Dorr HG, Versmold HT, Sippell WG, et al. Antenatal betamethasone therapy: effects on maternal, fetal, and neonatal mineralocorticoids, glucocorticoids, and progestins. J Pediatr. 1986;108:990-993
30. Ballard PL, Gluckman PD, Liggins GC, et al. Steroid and growth hormone levels in premature infants after prenatal betamethasone therapy to prevent respiratory distress syndrome. Pediatr Res. 1980;14:122-127
31. Ballard PL, Granberg P, Ballard RA. Glucocorticoid levels in maternal and cord serum after prenatal betamethasone therapy to prevent respiratory distress syndrome. J Clin Invest. 1975;56:1548-1554
32. Banks BA, Stouffer N, Cnaan A, et al. Association of plasma cortisol and chronic lung disease in preterm infants. Pediatrics. 2001;107:494-498
33. Huysman MWA, Hokken-Koelega ACS, De Ridder MAJ, Sauer PJ. Adrenal function in sick very preterm infants. Pediatr Res. 2000;48:629-633
34. Ervin MG, Padbury JF, Polk DH, et al. Antenatal glucocorticoids alter premature newborn lamb neuroendocrine and endocrine responses to hypoxia. Am J Physiol Regul Integr Comp Physiol. 2000;279:R830-R838
35. Scott SM, Watterberg KL. Effect of gestational age, postnatal age, and illness on plasma cortisol concentrations in premature infants. Pediatr Res. 1995;37:112-116
36. Kramer BW, Ikegami M, Moss TJ, et al. Antenatal betamethasone changes cord blood monocyte responses to endotoxin in preterm lambs. Pediatr Res. 2004;55:764-768
37. Jobe AH, Ikegami M. Pathophysiology of respiratory distress syndrome and surfactant metabolism. In: Polin RA, Fox WW, Abman SH, eds. Fetal and Neonatal Physiology. 3rd ed. Philadelphia, PA: Saunders; 2004:1055-1068
38. Vayrynen O, Glumoff V, Hallman M. Inflammatory and anti-inflammatory responsiveness of surfactant proteins in fetal and neonatal rabbit lung. Pediatr Res. 2004;55:55-60
39. Crowther C, Haslma RR, Hiller JE, et al. Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial. Lancet. 2006;367:1913-1919
40. Vohr BR, Wright LL, Dusick AM, et al. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994. Pediatrics. 2000;105:1216-1226
41. French NP, Hagan R, Evans SF, Godfrey M, Newnham JP. Repeated antenatal corticosteroids: size at birth and subsequent development. Am J Obstet Gynecol. 1999;180:114-121