The role of heme in hemolysis-induced acute pancreatitis

Medical Science Monitor

Volumn 13, Issue 3, 2007, Pages

  Saruç, Murat ^a,c   Yuceyar, Hakan ^a   Turkel, Nurten ^a   Ozutemiz, Omer ^b   Tuzcuoglu, Isil ^a   Ayhan, Semin ^b   Yuce, Gul ^b   Coker, Isil ^b   Huseyinov, Afik ^b  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

^c NONE   (Turkey)

Author keywords

Cytokine; Heme; Heme oxygenase; Hemolysis; Inhibition; Pancreatitis

Indexed keywords

ACETYLPHENYLHYDRAZINE; AMYLASE; CHROMIUM; CYTOKINE; HEME; HEME OXYGENASE; HEME OXYGENASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; MESOPORPHYRIN; MONOCYTE CHEMOTACTIC PROTEIN 1; TRIACYLGLYCEROL LIPASE;

ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INHIBITION; HEMODIALYSIS; HEMOLYSIS; HEMOLYTIC ANEMIA; HISTOPATHOLOGY; NONHUMAN; PATHOGENESIS; RAT; TRIACYLGLYCEROL LIPASE BLOOD LEVEL;

ACUTE DISEASE; ANIMALS; CYTOKINES; HEME; HEMOLYSIS; NECROSIS; PANCREATITIS; RATS; RATS, WISTAR;

EID: 33947117276     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Andren-Sandberg A, Hafström A: Aspect on pathogenesis of acute pancreatitis. In: Dervenis C, (ed.) Advances in pancreatic diseases. New York: Georg Thieme Verlag, 1996: 101-5
2. Druml W, Laggner AN, Lenz K et al: Pancreatitis in acute hemolysis. Ann Hematol, 1991; 63: 39-41
3. Przybylowski J, Klos M, Kisiel E, Mierzwa-Slefarska H: [Glucose-6-phosphate dehydrogenase deficiency in erythrocytes observed in two cases]. Pol Arch Med Wewn, 1993; 90: 72-77
4. Brechignac X, Pinede L, Laplace S et al: [Acute pancreatitis, an unknown complication of acute intravascular hemolysis]. Rev Med Interne, 1996; 17: 172-73
5. Saruc M, Yuceyar H, Turkel N et al: An experimental model of hemolysis-induced acute pancreatitis. Braz J Med Biol Res, 2003; 36: 879-86
6. Saruc M, Ozden N, Yuceyar H: How hemolysis causes acute pancreatitis. Med Sci Monit, 2002; 8: LE51-52
7. Chen X, Ji B, Han B et al: NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology, 2002; 122: 448-57
8. Andoh A, Takaya H, Saotome T et al: Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology, 2000; 119: 211-19
9. Okabe A, Hirota M, Nozawa F et al: Altered cytokine response in rat acute pancreatitis complicated with endotoxemia. Pancreas, 2001; 22: 32-39
10. Wagener FA, Eggert A, Boerman OC et al: Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood, 2001; 98: 1802-11
11. Wagener FA, Volk HD, Willis D et al: Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev, 2003; 55: 551-71
12. Graca-Souza AV, Arruda MA, de Freitas MS et al: Neutrophil activation by heme: implications for inflammatory processes. Blood, 2002; 99: 4160-65
13. Raju VS, Maines MD: Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart. J Pharmacol Exp Ther, 1996; 277: 1814-22
14. Umenai T, Yokoyama M: Erythroid accelerating activity of rat serum in early stage of drug induced hemolysis. Tohoku J Exp Med., 1998; 186: 181-91
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem, 1951; 193: 265-75
16. Schoenberg MH, Buchler M, Gaspar M et al: Oxygen free radicals in acute pancreatitis of the rat. Gut, 1990; 31: 1138-43
17. Beri R, Chandra R: Chemistry and biology of heme. Effect of metal salts, organometals, and metalloporphyrins on heme synthesis and catabolism, with special reference to clinical implications and interactions with cytochrome P-450. Drug Metab Rev, 1993; 25: 49-152
18. Balla J, Jacob HS, Balla G et al: Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA, 1993; 90: 9285-89
19. Dong Z, Lavrovsky Y, Venkatachalam MA, Roy AK: Heme oxygenase-1 in tissue pathology: the Yin and Yang. Am J Pathol, 2000; 156: 1485-88
20. Jeney V, Balla J, Yachie A et al: Pro-oxidant and cytotoxic effects of circulating heme. Blood, 2002; 100: 879-87
21. Muller-Eberhard U, Nikkila H: Transport of tetrapyrroles by proteins. Semin Hematol, 1989; 26: 86-104
22. Eskew JD, Vanacore RM, Sung L et al: Cellular protection mechanisms against extracellular heme. Heme-hemopexin, but not free heme, activates the N-terminal c-jun kinase. J Biol Chem, 1999; 274: 638-48
23. Johnson FK, Durante W, Peyton KJ, Johnson RA: Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats. Hypertension, 2003; 41: 149-55
24. Baker WF Jr: Clinical aspects of disseminated intravascular coagulation: a clinician's point of view. Semin Thromb Hemost, 1989; 15: 1-57
25. Uhlmann D, Ludwig S, Geissler F et al: Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. Zentralbl Chir, 2001; 126: 873-78
26. Foitzik T, Eibl G, Hotz B et al: Persistent multiple organ microcirculatory disorders in severe acute pancreatitis: experimental findings and clinical implications. Dig Dis Sci, 2002; 47: 130-38
27. Eibl G, Buhr HJ, Foitzik T: Therapy of microcirculatory disorders in severe acute pancreatitis: what mediators should we block? Intensive Care Med, 2002; 28: 139-46
28. Martin W, Villani GM, Jothianandan D, Furchgott RF: Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J Pharmacol Exp Ther, 1985; 232: 708-16
29. Sadrzadeh SM, Graf E, Panter SS et al: Hemoglobin. A biologic fenton reagent. J Biol Chem, 1984; 259: 14354-56
30. Yan WW, Zhou ZG, Chen YD, Gao HK: Role of COX-2 in microcirculatory disturbance in experimental pancreatitis. World J Gastroenterol, 2004; 10: 2095-98
31. Zhou ZG, Chen YD, Sun W, Chen Z: Pancreatic microcirculatory impairment in experimental acute pancreatitis in rats. World J Gastroenterol, 2002; 8: 933-36
32. Zhou ZG, Chen YD: Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. World J Gastroenterol, 2002; 8: 406-12
33. Zhou Z, Zhang Z, Yan L et al: [The feature of pancreatic microcirculatory impairment in caerulein induced acute pancreatitis]. Zhonghua Wai Ke Za Zhi, 1999; 37: 138-40, 9
34. Sendur R, Pawlik WW: [Vascular factors in the mechanism of acute pancreatitis]. Przegl Lek, 1996; 53: 41-45
35. Moolenaar W, Lamers CB: Cholesterol crystal embolization and the digestive system. Scand J Gastroenterol Suppl, 1991; 188: 69-72
36. Hegewald G, Nikulin A, Gmaz-Nikulin E et al: Ultrastructural changes of the human pancreas in acute shock. Pathol Res Pract, 1985; 179: 610-15