A new target for antibiotic development

Science

Volumn 315, Issue 5817, 2007, Pages 1373-1374

  Wright, Gerard D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BAMBERMYCIN; BETA LACTAM ANTIBIOTIC; GAMMA GLUTAMYLTRANSFERASE; GLYCOSYLTRANSFERASE; MEMBRANE PROTEIN; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; PENTAPEPTIDE; PEPTIDOGLYCAN; VANCOMYCIN; AMINOACYLTRANSFERASE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; OLIGOSACCHARIDE; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; PEPTIDOGLYCAN TRANSPEPTIDASE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; COLIFORM BACTERIUM; DRUG DEVELOPMENT; ENZYME ACTIVITY; GENE;

CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROPHILICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; STAPHYLOCOCCUS AUREUS; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; METABOLISM; NOTE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINOACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; OLIGOSACCHARIDES; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCUS AUREUS;

EID: 33947106039     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1140374     Document Type: Review

References (6)

1. A. L. Lovering, L. De Castro, D. Lim, N. V. Strydnadka, Science 315, 1402 (2007).
2. C. T. Walsh, Antibiotics: Actions, Origins, Resistance (ASM Press, Washington, DC, 2003).
3. J. Halliday, D. McKeveney, C. Muldoon, P. Rajaratnam, W. Meutermans, Biochem. Pharmacol. 71, 957 (2006).
4. B. Ostash, S. Walker, Curr. Opin. Chem. Biol. 9, 459 (2005).
5. C. Evrard, J. Fastrez, J. P. Declercq, J. Mol. Biol. 276, 151 (1998).
6. G. H. Talbot et al., Clin. Infect. Dis. 42, 657 (2006).